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Cures For Hair Loss 2023 - News Feed

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Arcutis Biotherapeutics Completes Enrollment for Phase 1b Study of ARQ-255 For Alopecia Areata

Arcutis Biotherapeutics, Inc. has completed enrollment in its Phase 1b study of ARQ-255, a topical suspension containing ivarmacitinib, a selective JAK1 inhibitor, designed to treat alopecia areata. Utilizing Arcutis' proprietary Deep Dermal Drug Delivery (4D) technology, ARQ-255 aims to penetrate deep into the skin to target inflammation at the hair follicle base. The study will assess the safety, tolerability, and pharmacokinetics of ARQ-255 in healthy adults and individuals with patchy alopecia areata. Results are anticipated in the first half of 2025.

Pelage Pharma Doses First Patients in Its Phase 2 Trial

Pelage Pharmaceuticals has announced that it has dosed the first participants in its Phase 2a trial for its androgenic alopecia treatment PP405. PP405 is purported to stimulate hair follicle stem cells, triggering dormant biological processes and reinvigorating the natural hair growth cycle. This compound is said to work by targeting specific cells within the hair follicle, aiming to reawaken their ability to promote hair growth that may have become inactive over time. The trial will include 60 men and women and study its efficacy and safety.

Recent Research Finds Potential in Sugar Molecule to Improve Hair Loss Outcomes

A recent study that has come out of a collaboration between Sheffield University and COMSATS University Pakistan has been published in Frontiers in Pharmacology. This study utilizes a sugar naturally found in the body called 2-deoxy-D-ribose (2dDR) in mice injected with testosterone. The researchers found that 2dDR was able to improve hair regrowth at the same level as minoxidil. While the results are interesting, it should be noted that the study has been conducted in mice and, therefore, might not translate well to humans.

Dr Bloxham Posts New Verteporfin Update

Dr Bloxham has posted the next update for two out of three patients in his observational verteporfin study. You can check out the video here. We will also be updating our Verteporfin page with the details of the video within the next few days, so make sure to keep checking.

Kang Stem Announces MOU with HLB Biostep and HLB Biocode

Kang Stem Biotech has signed a memorandum of understanding with HLB Biostep and HLB Biocode to develop an organoid-based platform for evaluating drug safety and efficacy and advancing cell therapy products. This collaboration aims to commercialize an alternative to animal testing, using organoid technology to predict human drug responses and enhance non-clinical toxicity evaluations. The company plans to seek early IND approval for a hair loss treatment using skin organoids. The CEO of Kang Stem has emphasized the synergistic benefits of combining the companies' expertise in organoid technology, treatment production, and evaluation techniques. 

Kintor Pharma Announces Clinical Trial Using 1% KX-826

Kintor Pharma has not given up despite no statistical significance being found for its recent Phase 3 trial. While the company has previously used 0.5% KX-826 in its Phase 3 trials, it has just announced that the National Medical Products Administration (NMPA) in China has approved the use of an increased concentration of 1% KX-826 in a clinical trial for male androgenic alopecia. We look forward to seeing what results are gained from this.

Inmagene Completes Enrollment for its Phase 2a Trial of IMG-007 for Alopecia Areata

Inmagene Biopharmaceuticals has finalized patient enrollment for its Phase 2a clinical trial of IMG-007, a nondepleting anti-OX40 monoclonal antibody, in adult patients with alopecia areata (AA). The trial will assess IMG-007's safety and efficacy, using the severity of alopecia tool (SALT) score in patients with over 50% scalp hair loss. With an enrollment of 29 patients across 11 sites in the U.S. and Canada, the study will evaluate the impact of three infusions over four weeks, with a follow-up period of 24 weeks. Topline results for this study are expected in Q4 2024, which will guide further understanding of the drug's potential in treating AA. 

OliX Pharma Announces New Data at the World Congress for Hair Research

OliX Pharmaceuticals, a Korean biopharmaceutical company that focuses on developing RNAi therapies, has recently announced some results from its hair loss indication OLX104C (an asymmetric siRNA targeting androgen receptor therapy) at the 13th World Congress for Hair Research (WCHR 2024). A collaborator working with OliX on research on OLX104C, Dr Jonghyun Won, presented the data on the hair loss inhibition effect of the drug and the long-term impact of the drug in dermal papilla cells, human hair follicles, and mouse models.

While no results have been discussed in any press releases, they have been described as "promising", so we hope to get some published news soon. 

The presentation at the WCHR was titled "Efficacy of Asymmetric siRNA Targeting Androgen Receptor for the Treatment of Androgenetic Alopecia".

 

Stemson Therapeutics and Aderans Announce Exclusive Licensing Agreement

Stemson Therapeutics and Aderans, the parent company of Bosley and HAIRCLUB, announced an exclusive global licensing agreement to develop and commercialize hair regeneration therapies on March 8, 2024. Stemson will leverage Aderans' Phase 2 clinical-stage cell therapy technology to enhance its product pipeline for hair loss. Aderans' platform uses patient-derived cells to rejuvenate hair follicles in individuals with androgenetic alopecia. Stemson will integrate Aderan's technology with its iPSC-derived cell therapy to create advanced solutions for various hair loss conditions. 

Dr Bloxham – Verteporfin 5 Month Update

The wait is over for anyone interested in verteporfin. Dr. Bloxham has released a YouTube video update for his verteporfin experiment, which you can find here. We will also be updating the main article, so stay tuned.

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