A Look Ahead At Hair Growth Therapies in 2021
TH16 Release Update (2/25/21)
As mentioned, the all-natural OTC hair growth product TH16 by Triple Hair was slated to be released in Q1 2021. Not very unsurprisingly, it seems that the projected timeframe will have a slight delay. Today, I heard back from Attila Hajdu, Triple Hair VP of Business Development, who was able to provide a clear update on the status of the product.
According to Hajdu, Triple Hair is currently working to establish distribution networks in Turkey, US, Middle East, and will have their own website for sales. The ever-important release date will be in May 2021. Remember, TH16 is suitable for both men and women and was tested head-to-head against minoxidil with positive results.
Original Article
In this post we will review progress points for the more relevant treatments being developed for the hair loss cure industry in 2021.
Clinical Hair Therapies In 2021
Samumed – The San Diego-based biotech with Turkish origins, Samumed, currently owns the furthest developed drug in the hair cure industry. Samumed’s wnt-activator SM04554 is undergoing a phase 3 clinical trial in Turkey with an estimated completion date of January 2021, according to its clinicaltrials.gov page. While the drug is not slated to be a powerhouse, it could be a valuable stacking treatment or alternative to current approved drugs for many folks if it becomes approved. Look for an update on SM04554 before summer 2021.
Breezula – This androgen-receptor-antagonist from Cassiopea is currently the second furthest developed drug in the hair growth industry. A phase 3 trial was anticipated to happen in 2020 but due to the unexpected occurences of 2020 the trial was delayed and is expected to commence in H1 2021. Cassiopea also has a phase 2 trial underway for female patients using Breezula which is expected to report data in Q2 2021.
Follicum – Another late-stage topical drug, FOL-005 from Follicum will be reporting important phase 2 trial results in Spring 2021. This trial is especially important for Follicum because it is the first time the peptide FOL-005 has been tested topically in androgenic alopecia patients. If results are favorable (around the 10% density improvement mark or better) there is a good chance that a larger industry partner will swoop in to take the drug into a pivotal phase 3 trial for market approval.
Shiseido – The surprise follow-up trial of RCH-01 by Shiseido should be winding up in Q4 2021, though, it is not guaranteed that we will see its data next year. This time, the trial will involve multiple injections of dermal sheath cup cells over 12 months. Hopefully, meaningful results are seen this time around.
HairClone – Although HairClone is not technically offering a treatment themselves in 2021, it is mostly assured that the company will be ready to provide cultured/expanded dermal papilla cells to physicians in the UK who can use the cells to treat patients in 2021. A few timely government grants in 2020 were able to keep HairClone afloat and moving towards their goal of human application in 2021.
Kintor – As of December 29, 2020 Kintor has completed enrollment of a phase 2 clinical trial testing its androgen-receptor antagonist pyrilutamide in 120 male patients in China. The trial will involve multiple dosing cohorts and be carried out over a 6 month period. According to Kintor’s latest press release: “The Group expects to finalise the clinical study report (CSR) and release data for Phase II Clinical Trial in 2021 and commence a phase III clinical trial (for pyrilutamide) in the second half of 2021.” Kintor sounds awesome at this point, let’s hope they make good on their forecasts.
Stemson – While a clinical trial for Stemson in 2021is possible, it is more likely that we would get a timeline for a Stemson clinical trial at some point in 2021. Stemson is the only current active hair multiplication company based in the US and has recently pulled in a $7.5 million dollar investment from Allergan and a UK firm to get their program rolling ahead.
As you may have noticed, there certainly are other clinical stage companies we could hear from in 2021, such as J. Hewitt or Dr. Tsuji/Riken. However, at the moment I felt it best to keep the spotlight on the above listed companies.
Over The Counter Hair Therapies In 2021
Triple Hair TH16 – The all-natural OTC in Triple Hair’s pipeline, TH16, is expected to be released in Q1 2021 according to the company’s website. According to the company, in a self-sponsored clinical trial, TH16 outperformed 5% minoxidil in human patients. Though specific data numbers have not been disclosed, there were some decent looking photos shared in a Follicle Thought exclusive article. The main ingredients of TH16 are allegedly resveratrol and melatonin, two compounds that have shown to support hair growth in lab studies. The formula will be marketed to both men and women. Stay tuned for further updates direct from Triple Hair management in Q1 2021.
University of Wisconsin Hair Cap – Back in September 2019, news sprang from the University of Wisconsin that a unique new wearable device could become a new useful treatment for hair growth. The device gathers energy from its wearer’s daily movements and then outputs low-frequency pulses into the scalp to stimulate hair follicles. As the news was well received by many media outlets it was expected that a small university-based clinical trial would commence in 2020, but, due to widespread delays there was seemingly little to no progress made by Dr. Wang in getting his electrical hair cap into a human clinical trial. In my last communication with Dr. Wang in August 2020 he was still set on pursuing a trial for the cap as soon as it is tenable. Look for an update on a trial in H1 2021.
Please comment below which treatment you are most looking forward to hearing about or trying yourself in 2021
Posted in Hair Growth Treatment
I’m looking forward to Kintor’s progress and hoping to see a hair multiplication trial get underway in 2021.
Hi admin i have a question,is the FOL 005 result long lasting ( i mean does the result sustain for few months after stopping,and then probably we would have to apply again) or is it like minoxidil where the growth effect immediately stops after stopping the drug.
Hi Shayak, thanks for visiting. At this moment we will not know if FOL-005 is long lasting until the drug reaches the market. Follicum will not report back how its users are doing long after the duration of a 4 month clinical trial because that’s not part of the protocol. Likely, we will have to wait to get an answer to your question.
Thank you for your response admin!
Is there any way that DUPA sufferers can get hair cloning done? Or will it not work because all of the hair succumb to miniaturization?
A lot of people have asked this question and even the companies working on cloning do not have a clear answer at the moment. Consider this, DUPA sufferers still have some hairs that maintain on the sides of their scalp right? These hairs may not be fully immune to DHT but they show some resilience. What if the cells from these hairs were cloned and the follicles had about 70% resilience in the face of DHT compared immune hairs. That would be fine, yes? Or, what if they could produce hairs at 40% resilience. All in all, if we can clone hairs and continue to clone them, it should be a reasonable issue for everyone, even DUPA sufferers, we just need to get successful cloning going.
Thanks for the update Admin! It’s highly appreciated as always 🙂 I’m looking forward to seeing the results of Samumed, and SULT1A1 in January 2021.
Admin, since you’ve received your bottle of SULT1A1, will you be providing us with an update on your progress at say every 3 months? Like at 3 months mark, 6 months, 9 months, 1 year mark?
Also, it would be amazing if Triple Hairs TH16 really does outperform Minoxidil 5% when the results come out. That would be a gams changer for especially for a natural product.
Succinct, yet informative, thank you very much! What about my favorite underdog, Histogen, aka pre-2004 Boston Red Sox.
Sonic, thank you. I actually passed the sample bottle along to an acquaintance to use.
Hi Admin, can you give us an estimation for the release date of SM04554 ?
Thank’s
At some point in 2022 is a possibility, that’s as specific as it can get now.
I’m putting my eggs into the Kintor basket.
TripleHair also seems like they know what they’re doing.
Breezula will be a significant call either way.
I ain’t holding my breath for the rest, but have a feeling that we’ll be receiving more news of potential pathways we are currently unaware of in 2021.
It really looks like we are witnessing the transition into the second generation drugs for hair loss, it doesn’t look so grim after all. I am excited about kintor, a sideless antiandrogen is the best thing that could ever happen to those of us who still have hair to save and also for the new generation of men and women that will have to deal with this burden. Also, even if you have lost ground, with a safe antiandrogen and a good trasplant you can be set for a long time, it’s basically a cure for a lot of people. Sadly I still see hair cloning as far and way too expensive treatment so I’m not too hyped about that.
Happy new year everyone, sending you a virtual hug
Hi, I am looking forward to an effective topical treatment without a vasodilator. My heart is fine and so are my hormones. I am a healthy 60+ aged woman with female pattern hair loss and very distressed by the lack of useful treatments, but encouraged by all of the research, and hopeful for a useful result in the near future.
Thanks for the feedback Miriam.
In regards to the AI (Artificial Intelligence) company in the pipeline. I’m not trying to be negative about it, just logical, hear me out:
AI has been used for decades, and we are still where we are at.
What is it that we think AI will change?
Same with people talking about quantum computing will change it all.
How is all of those things going to change, if we have no models to work with?
Its almost like saying “if I get running shoes, then i can run a marathon” even though you never done any running at all.
So I have a hard time imagining what it is that AI is going to do, to help with advancing R&D in hairloss (because no information that we currently have is sufficient for advancing hairloss treatments).
Sonic, the AI takes care of the many, many hours needed to do preclinical screening to find the right molecules. It helps with drug discovery. I did an article on it recently you could read it.
Thanks for the summary FT. 2021 can only be better than 2020.
There is much here to be hopeful about. Personally, I am very much looking forward to the start of the Stemson trials. I know that any clinical application is some years off, but as my hair loss is pretty advanced, and I have tried minox and fin without success, I am pinning my hopes on hair multiplication. At least if you have enough donor hair you can plan a transplant. Alas, that doesn’t work for me. So hair multiplication would be a life saver. PS like many others, I’d also love to know what is happening re Tsuji/ Riken and whether this might get back on track in 2021. Needless to say, the more real cures there are out there the better, and the sooner prices will come down so they are affordable to all. I’ve been lucky in the sense that my hair loss has happened slowly over some 35 years, and I now have money to spend on this. Had my hair come out like this in, say, my twenties or thirties, it would have been far more difficult to handle (given I still find it upsettiing at nearly 60!). So I really do feel for youger guys. But hang on in there. Things have never looked better. I wish we had been this far towards a real cure when I was a younger man. Still, better late than never. Best wishes for 2021 to admin and everyone. It has to be a better year than 2020!
Have you tried Microneedling at 1.5mm once a week + Using Minoxidil 5% twice a day (morning and evening)? People usually get quite a lot of hair when they combine microneedling.
Some people get lots of hair growth with only microneedling, so combining Microneedling with Minoxidil will give even better results.
While many therapies are years away, others may be available soon. Thanks admin for the update. Will SULT1A1 from applied biology be available for order in January? I wish you all the best for the year 2021. Stay healthy!
I’ll go for Shiseido! 🙂
Nothing about Follica? Is that a mistake or intentional
The answer is Nick, all signs are pointing to the fact that the first generation of Follica will be microneedling + minoxidil. I don’t see it as a very big innovation at this point due to the fact it basically exists on the market now. If it somehow turns out there is something else involved my interest will increase.
Admin personally what do You think about Stemson, in Your opinion will they start human trial within next 18 months?
I am an optimist al, so my intention and hopes are for them to start the trial in the next 18 months. It may be close to a coin-flip, but with the money they’ve got it is absolutely feasible for them to get a trial going in H1 2022.
Given that Follica isn’t doing anything new, why are they going through all these expensive, time-consuming trials?
To get an official FDA approval stamp and market to doctors, etc. It would be a big claim they could make and get into a lot of dermatology offices.
What about Giuliani, Polichem, Applied Biology and Gurus? … They all should have something in 2021.
Giuliani is already out; topical finasteride has existed for multiple years (yes I will still cover Almirall once it becomes more clear); Applied Biology has some tests to finish which will come very soon, they could have made the list but I’d rather wait until the next important tests come out; and like I’ve said after I did not receive a response from Gurus about their product my expectations and interest have been quite low.
So nothing that will eventually be on a par with minox+needling let alone beat it. Nothing against admin he did good work, but this really depresses me. The fact that we’re completely stuck with preclinical development regarding genetic switches and signaling pathway development (no major paper over a year) just show you interest and honestly quality of people that operate in this area. Even if cloning or stem cells or growth factor treatment miraculously advances we would basically have a treatment for a process that we don’t understand.
Nice breakdown admin and very precise. The reality is there will be new generation treatments but…..they wont produce better results than the big 3 based on their latest clinical trials results: Samumed, triple hair, breezula and follicum. Now stemson would be the game changer for the 2020 decade. I am excited that SM could be out in the next couple years. Even if its only 10% regrowth it should maintain and thicken existing hair. It will also give us long term finasteride users where it has lost effectiveness another tool to kick start regrowth and maintenance. 🙂
Thanks for all of the positive feedback guys, I hope 2021 surprises us all in a good way. Also, when I looked at the list of late stage drugs (SM, Breezula, FOL, Kintor) that’s a good number of new potential drugs. ?
Could you post a link to the official product page of Giuliani? I cant find it and there seems to be no reall results released?? Is it the Way analog or one of the other products they work on?
Also what about Stem Cell conditioned media and Exosomes?
Thanks for the summary Admin, nice work! I have no favorite, anything that comes to market which actually does something will impress Yoda. I will say I’d be shocked if Follica is simply “micro- needling and minoxidil”. I’m doubtful that this is the case with all the time and money that’s being dumped into it. My guess is that the device is a level above micro-needling, maybe the minox is enhanced with other goodies. Just speculation on my part, guess saying that is only going to be “micro- needling and minoxidil” is also speculative. Unless admin knows something concrete that slipped by Yoda or has an inside track?
Thanks for the kind words Yoda, as I mentioned I’m not 100% sure about Follica being that but all signs are pointing to it. The biggest factor is the new published female study – treatments used were the Follica microneedling device and topical minoxidil – that’s it. One would ask, why do a study on females if you’re not using your full repertoire? My current estimation is that it’s about 80% chance I’m correct. Definitely would rather that Follica has something else up their sleeve but we’ll see.
Happy New Year everybody
Thanks Admin, I THINK at the very least if it’s a needling device, which I believe is only for in clinic use, it will have the depth and speed of operation optimized as opposed to what has been attempted in the home (even by Yoda). It could also be some sort of skin disruption device above and beyond needling, based on the same principle. These options could offer better outcomes than the simple needling that’s been attempted thus far. Or not! 🙁 I’m not a Follica fanboy but it appears to be one of the next things that could get approved and is actually in late stage clinical trials on human beings.
Hey, also…HAPPY NEW YEAR to Admin and all!!! Wishing for a better, healthy happy, hairy 2021 all the way around.
Happy new years guys. Been growing my NW 4 out over the past few months and going slick back Tony Soprano fuck it style vs trying to cover. Still check in daily but I know it will be 5+ years before we see anything substantial. Still holding replicel stock for shits and giggles down like 65%. Staying away from HSTO as per garage recent results.
Woofy needs to chill out for 2021 lol. Worst case hookers and blow hommie.
Cheers ,
JC
Johnny Martin is en fuego this New Years day! 🙂
Thanks Admin,
I am lookimg forward to TH16 and the Mane device. I saw the presentation provided in a link in the previous thread. It sounds more or less identical to the UW Madison cap. Probably earlier on the market here in Eurppe.
I could use both treatments in addition to my existing treatments. (Avodart, needling plus oral minoxidil once I can get hold of it)
Altough, using a topical could be quite challenging for me.
And Follica of course but I am not too optimistic that it will be released this year.
I’m curious to know why no one talks about laser caps. They’re so confident in their tech, they offer a 1 year refund if regrowth doesn’t happen. I started a HIMS daily regime a little after I started a laser cap (every other day) routine, and I’ve had significant regrowth in the crown. I honestly don’t know which regime to attribute it to, and I don’t want to mess up the program to find out. That’s one odd gift 2020 gave me.
They refund ~20% when you pay 1000+
Still they get 400% more than one they don’t offer refund It was big news LG laser helmet then it faded
@FollicleThought Samumed is a potential knockout for under 45s and with nw3 or less, check their data from phase 2
Phase 2 results were ~10% density increase after 4.5 months. I’m not knocking them, I appreciate that they exist, but that’s a minoxidil (or lesser) type result.
Samumed has a similar percentage to minoxidil, but the interesting thing is that it works in another way, right? Thank you very much for your articles admin.
Samumed had 10% increase after 90 days of applying and 45 days without lotion. Which is actually really good considering, that people usually get most of the gains during months 4-8 while on big 3.
You’re right the phase 2 was only 3 months of application. Optimism is typically a good thing, I just try to make sure I keep my evaluation of a drug realistic. Phase 3 results for Samumed should be here sooner than later and give a better picture of what SM04554 can do after at around a year’s time.
I agree with you on this. Longer usage not necessary means better results. Shiseido with RCH-01 is a good inspiration for it. Also I read on forum, where someone shared a study, where doctor claimed, that Minoxidil acutally works with adressing the wnt signals. That means that SM might have the same issue as everyone only on minox. Androgens will still catch you. But we will see some time in Q2.
If moongene or stemsontx could you know, hurry up! that would be great. My donor area is in very good shape for trials.
Woory are You from UK?
No but I can travel
i think there is enough bald people in UK Woofy
Generally they only make the trials available for residents of the country. You wouldn’t be able to get a VISA long enough for the whole period of the trial most likley.
Hi FT, how long do you think until Samumed goes commercial? any estimate?
If the trial concludes in Q1 2021 as planned then perhaps around Q1 2022 in Turkey for commercialization.
Hi OP. I came across this stem cell doctor from Australia today after a patient posted in a Craniofacial Facebook group about getting great results from treatment. You may have come across him before but thought I’d let you know in case you hadn’t. The guy might be an interesting person to interview for the site. Regards. https://clinicalstemcells.com/photo-gallery/
I was in contact with him recently in regards to zinc thymulin. He mentioned the following his reply.
“I am also working on a new direct hair follicle stem cell migration treatment for AA. The lab results were incredible and I just need to try it clinically on a few people in Australia. Again very safe natural compounds are used. It should be available at the London Marylebone clinic when I can travel back to UK.”
Wow, that sounds like great news. The photos on his site are quite impressive so it will be interesting to see how things progress with his Australian patients. Are you able to get the zinc thymulin topical from him online or do you need to go see him in person? I only contacted him a couple of days ago so still waiting to hear back.
You can get it sent from him, but its expensive and didn’t produce great results for those who used it on HLT.
What does HLT mean? Hair loss treatments? You mean if people are already using hair loss treatments like minoxidil etc it doesn’t really work? Also what exactly is the cost and are you looking at trying the treatment yourself? Sorry in advance for all the questions 🙂
HLT is a message board for people interested in hair growth treatments.
Anything new about CKBiotech? Or more specifically, KY-19382
Admin, have you ever looked at Stem Cell Educator Therapy? Do you research the cures for Alopecia Areata or just Androgen Alopecia? I’m always looking for information for my granddaughters Alopecia Totalis. Thank you for all your information!
Thanks Tammy. My initial short response: I believe I’ve heard of this treatment a few years ago when another concerned parent was seeking this treatment for their child. It may be effective for some but I do not see it as a ‘go-to’ therapy that is catching on with AA research foundations or dermatologists.
@Soul
please post that Mane translation
kapil sorry i forgot. I have translated it in the previous article to leave this one with topics related to the new article.
Thanks Soul
Thank you Soul. I understand there may be translation issues but Yoda’s quick take is that it’s at least 3 years away and it sounds like hocus pocus. I’m not saying it is, it’s just my impression. I wouldn’t put a lot of hope in Mane, however if it comes to market with irrefutable evidence that it’s effective for reversing MPB Yoda would be one of the 1st in line.
Hi Yoda, yes sorry there could have been a mistake because I translated it from German to Spanish and then from Spanish to English. I don’t pay much attention to it either, but welcome.
Hello Yoda…Mane appears to be the European UW-Madison device. My impression is they are looking for participants for their product testing phase. I actually have shown interest as I do not live far away from Vienna but because I am already on treatments, Manes interest in using me as guinea pig is most likely rather limited. Will it have any effect? Only god knows but at least its no medication and no greasy topical. From the application side…almost a dream.
Where’s Follica?
@FollicleThought
Do you have any information to share about Samumed and if their Phase 3 trials meet the requirements for both the FDA and EMA? There’s a lot of talk about it being approved in Turkey in 2022 but what about america and countries within the european union.
Hello there, everyone.
Has anyone experienced a decrease in stubble density? About a year ago, I could go grow a thick beard with no problem. Now, it seems relatively patchy and less dense. I don’t have thick patches and thin patches — it’s just like I have my density is thinning out. I’m almost 40.
I went to see a dermatologist, who said that it wasn’t alopecia barbae. She tried steroid injections, but they didn’t seem to help.
Anyone have any experience with this? Anyone have any idea how to treat it? If I can treat it, that is.
Thanks to everyone who checks the site and the comments section daily looking for new tidbits.
I have a brief, yet positive, update to share. I reached out to Triple Hair this week and received a response that the TH16 over the counter product is still on track to be released in Q1 2021. This is good to hear and hopefully creates a new pattern of companies delivering on their projected timelines in 2021.
Will have an article on a new potential player soon.
I’m most excited to look at results from Wang’s electric hat. It doesn’t seem likely to be a cure by any means to me, but, if it even has modest results, the fact that it likely won’t have any side-effects due to its non-pharmaceutical nature is great. As well, since it’s a non-pharmaceutical treatment we could see it on the market in only a year which is why I guess I’m most excited for it.
Yeah, I hope they start the trial this year
Hi Admin, hi readers,
For me this is the article I was waiting for. So many thanks to you, admin, for this overview and your work in common. If you don’t mind I will post my thoughts on the future, how this all will turn out and what also should be done/researched in a few posts, followd one by another under this article. Sorry in advance for some missspelling and gramatical errors but I’m not a native speaker.
1. The near future
I think with all this companies in different stages of theirs studies this will be the decade of the hairloss cure and maybe even the cure for baldness. Obviously not by tomorrow but within the next years. Which is pretty awsome. To all these people saying “Oh …I heard this before. For the last 20 years the solution is just around the corner”. This time it is, I’m sure. From now on it will start a little slowly but than … bam…one company after another will bring their solutions on the market. Certainly one will be more effective than another, but the pure fact that there will be more than the big three is more than fantastic. So lets see what brings me to this thinking. Its all about planing. In fact its like a little journey you have to go through the next years. But it will be worth the effort. Beforehand I want to say, the most important part of this journey will be that you make sure your follicles stay more or less healthy (or at least alive) in the next 3 to 5 years. The real game changer will be DPCell and/or Stem cell therapie. For the best results in this near future it’s most important that these therapies can catch on something which is still there. After all this reading on different HL-pages and papers I still don’t know if follicles can really “die” forever or stay as “permanent resting” in your scalp. Some say so, some say so. I hope for the second one, but in terms of planing consider the first one. So even if you will lose hair within the next years with the current treatments and the upcomming treatments it is more likley that there will be more follicles in your scalp to catch on than without treatment. That means don’t stop it even if the results are not as good as you expected. A follicle not producing hair or just velus hair is more worth than a dead one. You might think that this is said easier than done. So here is the plan. If you current treatment works, just go on. If not, also go on with it and by the time (in about one or two years) the next treatments are coming up just add them. Samumed, Breezula, Follicum, Kintor, Triple Hair, Mane, maybe Wisconsin Hair Cap. Lots of opportunities. Certainly at least one of them is really good as an addition to your treatment. I know that all of them have to be done every single day, which is quite annoying because everybody waits for the treatments you do maybe once a year or so. But how I said before, its worth it. And for those who say “These are just snake oils or useless devices”. That’s ok, but keep in mind, that there is serious science behind it and we followed them the last years (Thanks again, admin!). This has never been the case in the past. All these companies are in some kind of a spot light and are all (nervously) watched all over the world. They just can’t afford to bring a snake oil to the market, because they would get ripped apart by the “community” in no time. So lets pretend in about two years we all have the treatment (combination) that works. (At least for keeping the existing follicles). There are only two or three years left and we all can hop on the CellTherapie-Train. Imagine how it will feel when all the preasure falls of your shoulders. For most of us, it will be kind of the end of that exhausting journey. It probably still means that you have to get an injection once in a while, like you have to go to the dentist, but the rest of your life will be without any fear of further hairloss. Pretty awsome, isn’t it? What else can you do to make sure your follicles stay as healthy as possible. Don’t poison your body, because everthing that gets in your body somehow gets to your hair. So stop smoking (if you do). Don’t get sunburned on your bald spots, it might damage your follicles irreperable. Also don’t do a hair transplant, I gues it will also destroy the still existing follicles in this area (but I’m not sure about that). Eat healthy. Lot’s of vitamines and lots of iron. Be active to make sure your blood circulation provides enough oxygen and nutritions to your scalp. Avoid stress. …but I’m pretty sure we all watch the same videos on Youtube so you all probably know how to keep your hair healthy. And I’m also pretty sure the rest of your body also likes that ? I know 3- 5 years is a long time for people waiting for something, but think in phases. It takes only about one presidential period in the US. Or its about the gap between two Quentin Tarantino movies. Or lets say by the time the 26th James Bond comes along we will probably see also the cure. Or only 25 more marvel movies 😀 Or lets say your kid is borne today. By the time it will go to school, there is at least one cure on the market that is just right for you. And in the unlikely event that the first wave (new treatments) and the second wave (new cell therapies) are not bringing the results you want, just wait for the third wave. Hair multiplication might also be available in about 5 to 7 years and than you can have a very dense hairline right down to your eyebrows if you want. We all heard that this will be very very expensive (not affordable) regarding to Dr. Tsuji work. But there are also other companies like Rapunzel or lets say Dr. Christiano. When you read her bio she knows exactly how you feel when you lose your hair. Therefore it is almost safe that her hair solution will be somehow affordable, as she really is interested in helping people and not making lots of money. Which will happen anyway if her solution is actually working. This third wave will also be the endpoint for people which have lost most of their hair too long ago (maybe 10 years or more) so the second wave (Cell therapie) can’t catch on anywhere (but how I said, I’m not sure about when or if a hair follicle is really “dead”). Or for people which are not willing to be hooked on a daily treatment with possible side effects, which for me is totally understandable. For all these third-wavers just think of the next years like it is a bad relationship you allready know will end at somepoint in 5 to 7 years. From now on you can pretend that this is one chapter in your life in which you didn’t have hair. It’s just an episode. It only can make you stronger and in about 10 to 15 years you are just laughing about that time, believe me. To come to an end of my first post, how I said, this is the decade of hairloss cures, this is our decade. So stay patient and positiv, safe hair follicles and money and most important enjoy life. Big times are coming!
2. Cure for Hairloss (mRNA-vaccine)
I’m not a scientist, but a biologist. Therefore I understand too little of the “deep stuff” but I think by reading your articles and papers elsewhere on the internet I have a pretty good understanding of the topic hairloss. So when I was sitting at my favourit lake the otherday thinking about a lot of things and enjoying the wintersun one thing came to my mind and I was wonderin why I havent heard or read anything about it by now. Here is the thing. As probably a lot of us in this last chaotic year we read a lot about Corona and vaccines and how this all works. One interessting new method in the field is the by-now-approved mRNA-vaccine of Pfizer/Biontech or Moderna. To keep it short, this vaccine is actually not a little dosage of the actuall virus which tells your body to create antibodies to fight the virus. It’s more like you put the information (mRNA) of an protein into your body, so your body produces this protein by itselfe. This protein is an “entering protein” of the virus (to get into the human cells) and is actually foreign to your body. So your body fights it. As your body is able to memorize, everytime something comes along with this specific protein on it, it gets fought almost immediately. Pretty awsome and safe in my opinion (not willing to lead into discusson about this vaccine, just let it sit).
So what has it to do with hairloss. As you all probably know the main reason why you lose your hair is DHT which is pretty willing to bind on your Dermal Pappila Cells. If you have sensitive DPCells DHT will kill them one after the other (simplified) and leads your hair to get thinner and eventaully causes the total stop of the follicle to produce hair. Nothing new. As you all also probably know almost everything that reacts in your body has something to do with proteins and enzymes. Also the whole stuff with DHT. Testosteron becomes through the 5-alpha-reductase enzyme DHT which bindes to the DPCells. Now to my conclusion. What if you bring your own body to fight something in this whole procedure so DHT can’t bind anymore to the DPCells. You certainly are not willing to fight Testosterone, 5-alpha-reductase or DHT, as this will have huge negative side-effects in your hormone balance. So you have to go to the very end of this whole queue to make sure that nothing else gets affected but the binding of DHT to the DPCells on your scalps hair follicle. That’s where I’m stuck because I’m not in the “deep stuff” but I’m quite sure there is something. And now back to the vaccine. If you get your body to fight that “something”-protein, that is involved in the binding process, DHT will never be able to bind to the DPCells anymore. That means no hairloss anymore (Not sure if this means also regrowth. Maybe a little bit). But how do you bring your body to fight something that is naturaly in your system. You take the information (mRNA) of this “something” protein and change it just as much so that your body thinks “Oh, I have not seen this before, I have to fight it”. It still has to be this similar to the orginal mRNA, that after bulding this antibodies for the changed one they attac the orginal protein too. It’s a very narrower degree I guess. It even might be impossible. But I think It’s worth a try.
There are also some things to keep in mind, if this actually works. First, it’s not reversible. That is good because that means you only have to get one or two injections (which should also not to be expensive -> one Corona-Vaccine-Injection of Pfizer costs abot 12 – 20€ for example) and than you are save for the rest of your life. The downside is of course you can’t get rid of it once you have it in you unless you get chemo. Second, it means that your body is fighting every single second of the rest of your life against this protein. Which is also good, but can also be bad. There have certainly be done a few studies in the future that show, that your immune system is not overwhelmed, when you get a flew or something that needs also to be attacted. But a positive side effect can also be better blood flow in your scalp because there is something going on around your follicles. Therefore your body sends stemcells, growthfactors, nutritions etc. almost constantly in this area. This can also mean that hairloss which is not because of AGA but because of changed blood supply (mainly because of age) can also be treated with this method. For this scenario also have to be done studies to make sure that there is no lack of stemcells etc. anywhere else in your body because of this.
That’s it. That was my thinking about mRNA. Maybe there is a scientist out there who reads this and is kean to give this a try. I think its worth it. And in the (unlikely) event that this really works you can have this idea for free. The only promise you have to give is that absolutly everybody is able to afford it by the time it comes to the market.
Next are coming a few short thoughts I have not read a thing about and I’m wonderin why. Just to give a little kickstart to think about it or even do a little research.
3. The Combining-Tale
Excuses in advance for this childish told theorie but I think to put the next one in a little tale-like costume helps to understand better what I think and also its more entertaining ? So this is the tale of stem and dermal papilla cells (including dermal sheath cup cells) which plays in a future of happy little follicles growing everywhere. Maybe this future is not to far away.
Imagine that a follicle is a house. There are very solid houses build up by non-sensitive DPCells and others are more likely fragile build up by sensitive DPCells. Once in a while the Lord of Testosteron sends out his favorite troup the “sons of DHT” not thinking anything bad would happen. But the troup has its own mind. As soon as they see a fragile house they demolish it a bit by killing a few of the sensitive DPCells. They keep on coming every now and than. Sometimes they are a little more aggressive sometimes they just hit it a little, but over the time the house becomes a ruin (resting follicle) with no or very less DPCells left over.
So there is this company (maybe Replicel maybe Hairclone maybe a completely different one) that sends out DPCells under your heads skin. As DPCells are very very social orientated they only go there where at least a few other cells are (meaning thickening/improving existing hair, maybe a little regrowth in follicles with some amount of cells left over but no full head of hair). And than there are these other companies that send out stem cells. They are workers. As soon as they see a gap anywhere they go there to repair it as long as there is still somebody left to tell them what to do (meaning the same as in the DPCell-case).
In the case of a ruin the DPCells are not willing to go there because nobody is there and in the case of the stem cells they are going there, but there is nobody left to tell them actually what to do. So than the time passes by and a lot of people think about how to rebuild these houses as solid houses but all their tries seem to be…not realy working. Not only because they just send their cells once and hope that this will do, but also they send just one kind of cell. So the teller of this story thinks out loud. What if you send two kinds of cells and on top of that more often. So the story goes on. First he sends out stem cells which see tha gaps in the ruin. They will go there and stay there for some amount of time. Then he sends out DPCells (about 2 to 3 weeks later). Normaly they would have passed the ruins, but now they see life in there. So they meet up with the stem cells and chat for a while. After some time the stem cell asks the DPCell if he knows how to build up this ruin and the DPCells tells that he exactly knows how to build up this house but he doesn’t want to do it alone. So the stem cell also becomes a DPCell and together they start to build up a solid house. But its quite exausting. So the teller sends out more cells. Again first stem cells than after two or three weeks DPCells. He repeats that every three month in the first year, every six month in the second year and than only when he thinks the houses are getting newly attact and demolished by the sons of DHT which hit the left over sensitive building structure. After a few years the houses are as solid as they need to be to stand every attack of the sons of DHT. And they life happily ever after.
What I want to tell you with this story is that all these more ore less dissapointing results of the last few years doesn’t mean that this is not working. It just is not working only on its own. These companies have to combine there forces and they will get some awsome results.
Sidenote to the fact that some of the companies only do one or two injections and think that this will do the job (leaving the two-cell theorie from above out to make it more clear). I take the DPCells as an example. Lets say a healthy follicle consists of 10 DPCells originally. With 10 DPCells the follicle grows a nice thick hair, just how it should be. Than DHT comes along…again…and destroys two of them. The follicle still grows hair but thinner. This goes on and by the time there are only 4 or 5 DPCells left the hair on top is just a vellus hair (little small blond hair). Everything under 4 DPCells means no hair. And 0 DPCells means a dead hair follicle (Still not sure about that). So now you get a DPCell injection. All the follicles with 1 or more DPCells left are binding some of the injected DPCells (lets say 2), but they are certainly not filling completely up to 10 (except for those that have lost only one or two DPCells by the time of injection), because it takes time and it is 3D (hard to explain, just take it as fact). So a follicle that had previously only 1 DPCell left and has now maybe 3 is still not growing any hair. Even after an second injection its is only a vellus hair (5 DPCs). The third injection than makes the difference. Still thin, but it is finally there (7 DPCs). At this point you need at least two more injections to make sure that this follicle/hair is thick and stays there forever (9 DPCs and than 10 DPCs because the first single DPC from the start was a sensitive one and will eventually die). Does that mean 5 injections and than your are safe. Unfortunately not. Lets take a follicle that has 8 DPCs at the time of the first injection and becomes a full 10. Further injections will not fill it further up. But it still means that the 8 DPCs from the start are sensitive and will vanish somewhere in the future. So in the periode of the first five injections (lets say this takes about one year) two more sensitive DPCs die and get filled up. Now you have 6 sensitive and 4 non sensitive DPCs. Lets pretend there will be no further injection. The 6 sensitive DPCs will also die and what is left. 4 non-sensitive DPC – which means only a small vellus hair. Dissapointing. But by knowing that it is quite obvious what to do. After a certain amount of time (maybe once a year) you have to get further injections just to compensate the still dying sensitive DPCs. Is that the full truth? Not yet. As you all know cells like do devide. No matter if sensitive or not. That can mean that you actually don’t need that many follow-up injections, because the non sensitive DPCs fill the remaining gaps on their own (This is certainly not proofen yet and this is also certainly what replicel/shiseido were hoping for in their last trail). So it all depends on the ratio between sensitive and non-sensitive DPCs. I would say if you have 6 or more DPCs the chance that it fills it up on its own it is more likely than it would be with just 4 DPCs. Nonetheless it takes time and you can’t be sure because you are never able to count the non-sensitive DPCs that are actually bound. Therefore like I mentiont before, I would do 4 to 5 injections in the first year, 2 in the second and than everytime when you notice any negative change (maybe once a year) untill your hairloss is completely gone. This is all great for people with early stages of hairloss, but what are these people doing with bald spots they had for many years. It probably means that there are no or too less DPCs left (0 DPCs). So for you: just read the above told “combination tale” again ? I’m pretty sure the combi with stem cells is their solution. You can also use them in early stages to boost your results but in my opinion it is not necessary as this will certainly be more expensive.
This leads us to the next question. Which stem cells should be used. There are allready companies out there working on stem cell treatments for hairloss. They will get them from your body fat, blood or your non-sensitive areas of your scalp, multiply them and inject them back into your scalp. In my opinion there are two mistakes in this procedure, if I understood it right (correct me if I’m wrong). First is the fact that these stem cells can become any other type of cells. So they go to your follicle see the sensitive DPCs and become a sensitive DPC on their own. That means you do have more DPCs in your follicle and (thicker) hairgrowth, but not for long because they will also die again. Probably after one growth circle. In my opinion it doesn’t matter if they are from the non-sensitiv area of your scalp or not (To be clear: this is obviously different with DPCells). Second is a economical reason. Regarding to stem cells you don’t have to use your own. As a few of you probably might have read in the last month, there are a few Docs in the US using mesenchymal stem cells (often called exosomes) to treat hairloss (with actually good results for a certain amount of time if you can trust the pictures. But after 9 month and a lot of money spent for only one injection the improvement disapears because of the reasons I mentiont above). These “exosomes” come from very healthy individuals, get multiplied and than injectet into your scalp. For me, it makes therefore more sence to use mesenchymal stem cells provided by a company that makes sure that everything is ok with them than to use your own. Especially if you are not in “good” condition. It will be way more expensive and time-consuming to harvest the stem cells of every single patient and multiply them, than to use the “maybe-even-better-stuff” which is allready there in huge loads. And by the time it gets a real FDA-approval, many other companies (in addition to the existing two or three offering these “exosomes”) will hop on the bus and it becomes actaully affordable (At the moment its a total rip off for the not really long-lasting results). Will it get FDA-approval? First I thought “Certainly not. No Data, no studies, nothing”. But now I have read that it is planned to be used to help covid-patients becoming healthy again. So it also has to become somehow approved. And if it gets FDA-approval it should not take that long to get an EMA-approval. Not really sure if this means that it also gets approved for hairloss treatment, but I see no reason why not. It was the same with PRP. Lets hope for the best.
One last thing in this topic. What would I do different in terms of trails and studies using DPCells. I would use the DPCells of facial hair (or even pubic hair) for injections as they are way thicker and have a different “shape”. You might think “Whaaaaat…!??” And I would answer “Only for trials and studies”. It is way more obvious if the injections really work or not when a completely different hair comes out of the head. I think it is not too hard to find crazy people for studies which prefer to have facial thick hair on their scalp for free than not having any hair. This might also be a solution for people with very thin hair or in the cases that not all of the resting follicles will come to live again with this treatment. Thicker hair means more density even if you have less working follicles. In some cases you may even be able to prevent your hair getting grey. That is certainly a study I would do. Just saying.
Ok, that was a long one. Sorry for that ? The next two are just superficial thoughts and therefore way shorter.
4. Hair Multiplication (Petridish)
This is really just surface thinking. I read about these asian guy who invented the ultimate petridish to grow hair (cant find it right now but I think you have heard of it) in 2019. This petridish or lets say the stuff that is in it provides everything a hair needs for growth. Also the petridish of Rapunzel might do the work. So what if you take a healthy non-sensitive follicle an cut it in half. Than you put the two halfs in this dish an see what happens. I know that this is just wishfull thinking but I’m not sure if anybody tried this before. Sometimes it cold be this simple. If it works not just try to cut it half the way up so it becomes an y-shape and see what happens than. When it recreated the lower cutted part, cut the rest above and see if it also recreats its own. Lets pretend that both halfs become fully functional follicles in about two weeks time and you cut them again…and than again and than again …and so on…than you have more than enough donor hair in about a half year than you will ever have with FUE or FUT. It is probably enough to start with 10 extracted follicles. 20 – 40 – 80 – 160 – 320 – 640 – 1280 – 2500 – 5000- 10000- 20000 follicles in less than half a year. Its not cloning, its not stem cell, its not 3D printing, just simply cutting in half. So in my opinion not even any approval has to be maid, except for the petridish to grow hair in it. If that works just find a company with cold-laser experience to create a machine for all this cutting (nobody wants to divide 10000 hair foliclles by hand) and you are set up perfectly. Now you offer this to all the HT-Clinics. For the patient this should not be so much more expensive, because your Doc has less work with the extracted follicle. He just has to send 10 of your follicles to this companie and a half year later he receives 20000 of them, which he implants in your head. Yeah, I know, wishfull thinking…but also worth a try.
5. GenEditing
And here is my last thought. Its more like a scientific interest. When I look around and see who is balding and who is not it is very often the case that the younger brother is not or way less bald than the older brother when he was the same age as the younger brother now is. In fact that is so often the case that I think it is not a genetical coincidence. Sure there are also examples out there which are the exact opposite but 8 times out of 10 it is showing exactly this scenario. If there is a third brother this one gets even later bald than the second one, most of the times. For me this leads to think that there is some kind of gene-supression happening in the mothers body through the previous pregnancies. Just research it to understand that. Maybe it helps when GenEditing becomes a thing ?
So that was it. Lots to read and think about. Maybe it starts something, maybe not. I just thought it would be sad if I keep my thoughts on the topic hairloss for me. Happy new year everybody.
Lots of love from Bavaria,
Pepe
Holy Crap Pepe…I don’t have time to read this, let alone can believe anyone has the time to write it! I’ll wait for smarter forum members than Yoda to read, digest and comment.
Can’t believe I just read that, but I hate to be rude.. but 90% of that was utter drivel and made no sense.
mRNA based therapies are a form of gene editing.. so I’ve no idea where you’ve separated the two.
Also, gene editing is still in its infancy in what it can treat. For example, sickle cell is just one variation in the nucleotide sequence of the HBB gene. Androgenic alopecia is polygenic trait which has hits on a stupid amount of snps (single nucleotide polymorphisms) these snps have multiple purposed. Genetic editing is helpful, but it wont produce a cure. Not in my lifetime.
“Sure there are also examples out there which are the exact opposite but 8 times out of 10 it is showing exactly this scenario. If there is a third brother this one gets even later bald than the second one, most of the times. For me this leads to think that there is some kind of gene-supression happening in the mothers body through the previous pregnancies. Just research it to understand that. Maybe it helps when GenEditing becomes a thing”
No, thats just wrong. As previously stated previously AGA is a polygenetic trait.. (there are multiple genes involved.. around 60 from what I can remember from the 2017 study.
The reason some brothers and others don’t is just luck of the draw. Its purely down to allele selection. The reason we see people who have zero balding when they have balding in the family (or vice versa) is most likely due to Genetic recombination.
Realistically, none of these upcoming treatments are going to groundbreaking. I’d love to be wrong, but all the evidence points to that. Maybe KY can do something, that we’re yet to see. But it wont be anything that can regrow a hairline. We’ve seen people experimenting with similar molecules without much success. Hell, you can even get the peptide its derived from and follow the protocol that they did with valporic acid.. people have tried it. No real results.
Hair cloning is the only game changer, will be interesting to see how stemson do when most others have failed. But even thats far from entering human trials. Stemson recently released a PDF that stated the following..
“After closing a $7.5M seed financing led by Allergan Plc, a division of Abbvie, and Fortunis Capital, Stemson is raising $15M in a Series A to fund product optimization in a pig skin model, which is expected to be our preclinical model to produce data for our first-in-human trial application. The funds will support development of the scaffold component, expansion and optimization of the cell production protocol, and multiple cycles of pig studies.”
So we’ve got multiple pre-clinical studies to go before they even get to clinical trial// realistically if this does come to fruition its at least a decade or two away… and thats the best case scenario. It’s more likely to not make it to clinical trials, or not make it past clinical trials. Bleak but true unfortunately.
@FollicleThought do you have any good news (unexpected) coming up for us?
I have a few new companies to announce, early stage. Keep holding the vision of good things and hopefully 2021 delivers for us!
Pepe….lol. bro! I felt like I was in college reading that in my biology class. Simplify it next time. I wish that you wrote comes true but I doubt it. We dont have cures coming out this decade. Msybe be replaced big 3 cocktail at best: samumed, breezula and follica. Hair cloning stuff like stemson is over a decade away to get that low dense hair line.
Mjiones Stemson maybe is 5 years away, we dont what they doing at the moment
It’s much further than 5 years away, a decade at the very least. Maybe 2.
“After closing a $7.5M seed financing led by Allergan Plc, a division of Abbvie, and Fortunis Capital, Stemson is raising $15M in a Series A to fund product optimization in a pig skin model, which is expected to be our preclinical model to produce data for our first-in-human trial application. The funds will support development of the scaffold component, expansion and optimization of the cell production protocol, and multiple cycles of pig studies.”
pre-clinical studies can take between 1 – 6 years.. Stemson plans on doing multiple.
https://www.youtube.com/watch?v=myKK-I8QQJ8&feature=youtu.be
pig skin model is familar with human skin model
Mjones, Yoda, al Budny, FT the timelines for future medical miracles don’t mean anything. When they will release it, it will be so random we all will be wrong. Lol
in my opinion, older people do not want young people to overcome baldness, they are just jealous, they want them to have complexes, a very bad approach, if not for us, let it end for the next generation
Yeah that’s it, you got me. Yoda is 58 and is one jealous MoFo. You win a prize Al Bundy for one of the most dumbass comments I’ve ever read. Also, generalizing and lumping everyone together into one bucket is priceless. Possibly you’re projecting your anger?
Yoda you are a pessimist when it comes to hair cloning, I can feel it in Your post:P I envy people who will never go bald, and it may happen soon, but let it happen as soon as possible, why should next generations experience this shit?
I’m not a pessimist, I just don’t think it’s going to happen soon (next 5 years). There’s a big difference between me sharing an opinion, making sure people know that it’s an opinion and you accusing me and all other people who are “old” that we never want it to happen. Really dude?
Al Bundy – lol come on man. Yoda is brings much experience and advice to the younger generation on this site. He tells them to save their hair by hopping on big 3 and not make the mistake of holding out on false promises from these cloning companies. I doubt he wants you to go bald dude. I dont want you losing your hair. I been struggling with this crap since I was 19. Been on finasteride for 18 years. Been on these forums since 2001 and seeing all these so called cloming companies only 5 yrs away. We are skeptical and learned that you cant rely on a companies public announcements or false promises. Look at tsuji for example. Yoda said that 2020 is impossible to release cloning and he was right. Many youngsters on here didnt hop on big 3 thinking cloning will save them. They prob went from nw1 to nw4 in 4 years and feel dumb. If they listen to yoda they would have maintained their hair.
Well said MJ…my biggest concern is false hope and holding off on treatments that will help. How many times did we read posters saying they we going to start saving their money to get ready to hop on a plane in 2020 to have Tsuji done? How’d that work out. I’m not happy about it but not devastated as I thought it was pie in the sky talk.
Yoda, you can write normally: D none of us know when hair cloning will be available, so why write nonsensical posts?
Did I write a prediction Al? You are a special person looking to argue, I have pity on you.
I do not share the opinion of advising other users to medicate, I have always thought that it is better to be informed by a doctor before taking medication and not by advice from people on the Internet. I medicate and take finas and dutas along with oral minox., but I do not like the advice as they are medicines that can affect the long term.
The people who frequent these sites are almost always the same and I don’t think they are waiting for cloning to rule out the big 3 forever, they are just trying to get information and have a possible orientation for a market release.
If it’s a bit annoying to have to read the same comments over and over again from some people, I hardly ever go into the comment section anymore, so I have to read the repeated messages that cloning is decades away etc., we already know their opinion! I don’t mean Yoda, since he is asked and answers what he thinks, I mean the “prophets” who have no idea if it’s possible or not.
My advice is that we use this source of information to orient ourselves so that we can draw conclusions but not be repetitive.
I agree with you Soul, and second the advice to consult with a doctor before taking/using any prescription med.
Soul,- if cloning came out tomorrow and if was 100% safe and it worked I would be thr first one to dish out 50k to do it or however much it costs. I hate taking drugs and applying minox every night. Believe me man I am not a fan of the big 3. I take it because I don’t want to be bald. I pray for a quick cloning miracle but I always get disappointed by these companies. Anyways…enough of my rant lol its the weekend! Holla
Mjones what we do know is that nobody knows anything! the best thing is not to be repetitive because believe me that makes me not go to the comments section because it bores. And not only I complain, in fact a relative in whom we are waiting for news of Hairclone has stopped entering the comments section for the same reason
Soul, you are a bit self centred here, you may have forgotten that most likely there are plenty of people new to this site every day who are looking for advice and they are glad getting advice in the comments section. The majority probably never write. My observation is that there are many trolls on hairloss forums and social media who are disseminating BS. I firmly believe some are also paid by HT butchers.
Even here you read sometimes garbage that nothing works. Instead of reporting for themselves they are generalizing their personal experience.
And in regards to medication, most experienced people on here always state to take it under supervision from a medical professional. Actually that should be clear without being said as you need a prescription. Obviously for a good reason.
And I will always repeat my conviction to use a new treatment only in conjunction with existing treatments that have been proven successful.
And you know what happens when misinformed or not informed at all…ask Woofy.
Mrk, Calling me egocentric even in a subtle way only shows that you have taken it as an attack, therefore you are egocentric. I repeat my point again, I mean repetitive messages and those that do not lead to anything like those that affirm things out of the desire to constantly vent. On drugs, I see a lot about how they advise you to medicate without naming a doctor. I myself take finasteride, dutas and minox, but under the observation of my doctor.
MRKA and Soul, Yoda thinks you are both excellent, rational posters that bring a lot to the conversation, that there is more common ground than differences that you share. Probably just a mix up in words in my not so humble opinion! 😉
Soul…you didnt understand what I tried to say.
My point is that there are many people who are grateful to read a post from people on here who try genuinly to help other people combating hair loss.
The posts from these people may be repetitive to you but they are not for the newbies. Do you understand this?
But you did not consider this aspect in your post thus my accusation…think about it.
I am certain Woofy would be glad if he had read the info provided by Yoda few years back.
And personally..rest assured that I take Avodart on medical supervision.
After all, its prescribed by my urologist for its original purpose.
Once I get Loniten it will be also under medical supervision plus bloodpressure monitoring twice a day.
yoda i just want to let you know that 58 is young, to me the age of old is 65-70. you’re not old to me
Thanks Sonny, and Yoda is a young 58 because I take care of myself. 🙂
Histogen trail update due in next week.
Keeping hope alive.
Mrk, I don’t mean Yoda, I mean only those who repeat the same thing over and over again!
Regarding advising, I only gave my opinion that the opinion of a doctor should be reported first. I never said you shouldn’t advise. I see many people posting that they are buying drugs through websites without knowing what they buy and without consulting a doctor first because they have read it from a forum. that’s my criticism!
https://www.youtube.com/watch?time_continue=261&v=myKK-I8QQJ8&feature=emb_logo
I guess Stemson is moving pretty quick
an old video, can You explain why You think stemson i moving quick? i cant see it in this video…
Mrka while yes I wish I read the stuff that yoda and others have said years ago, about Finasteride and preventing more hairloss. Instead of reading horror stories from people who say they have taken Finasteride and have gotten sexual side effects “don’t take this drug!!!!!!” and I also saw a video of Pennsylvania doctor saying “do not buy Finasteride it’s very dangerous” so I’m not putting all the blame on those people but it definitely helped get me to nw5. I don’t feel dumb but I terribly regret and I’m am upset at myself because I should have gone and seen a hair loss doctor quicker and really understood this. But it’s over and I’m on Finasteride now I would be Nw7 by now if I didn’t get on 3half years ago no doubt.
Woofy…you to still need to listen to the Yoda when I said that you must compliment the fin with a growth stimulator, e.g Minoxidil. I’m sure there is a topical version that would kickstart your follicles without irritating your scalp. If all else fails low dose oral minox under a Dr.’s supervision. Right now with fin only your pissing in the wind son.
Do you think that there would be a substantial progress in gray hair reversal this year ?
Correct me if I’m wrong but grey hair already basically has been cured it’s still a treatment but the person’s original hair color was restored.
And I’m not really a noobie to this site I’ve been a lurker since 2017 but I just recently in the last year started commenting.
Has anyone tried /zinc-thuymyln has mentioned above formulated by dr Vickers in Australia. The evidence looks compelling but nothing really out there from anyone saying they be used it.
Woofy97:
Has grey hair been cured? I have not seen anything about this anywhere.
Do you have any article?
It’s not a cure but it’s a damn good result https://www.sciencedirect.com/science/article/pii/S2352512618300158
The Samumed phase 2/3 clinical trial has Completed, an update was posted here https://clinicaltrials.gov/ct2/show/NCT03742518 now we await results.
Samumed phase 3 completed is the best real news we have had since 1996 when propecia was released. Even if it doesn’t work, at least one company fulfilled their promise and finished all 3 trials needed without bs lies, false promises and hype. I have a good feeling this will be our next fda approved hair loss treatment. I will guess it will complete halt of progression of mpb, thickening of all thinning hair and regrowth of 15 to 20%.
Mjones, do you actually think it could halt of progression of mpb, thickening of all thinning hair and regrowth of 15 to 20% or are you joking ?
exactly, I think the same. I don’t think Samumed does all that, it would be the cure practically. that’s why lamentations come later.
He is just guessing. Nobody knows.
? Fingers crossed!
From reading articles when Samumed was first introduced it said using stem cells to regrow hair and the same drug could possibly turn grey hair back to it’s original colour. Does anyone know if this is in fact possible? I’ve looked up WNT pathway and there are some articles that say it is important in both hair growth and pigmentation. Maybe grey hair reversal is an added bonus aswell as hair growth
Rookie question but is SM04554 a topical lotion or a pill? Good news
topical
I mean they achieved 10% new formed follicles and thickening of existing plus halt in progression from their phase 2 trial. I’m just hopefully guessing they improved their stats in phase 3 with better dosing. I’m just speculating of course. Fingers crossed for better results than big 3.
Great news to start off 2021!
When would you expect we’ll see the data and images of the results of the trial admin?
Hope everyones having a good 2021 so far!
Well after doing some research on Breezula I come to discover the main component of this drug is actually a steroid which could suppress the adrenal gland and result in catastrophic events in the body. I know they say systemic absorption is low but for many people it is not. Speaking from experience anything applied to the scalp may go systemic as some people’s scalps are very porous. Feeling a little discouraged as this is the same reason why I can’t use minoxidil, it went systemic and lowered my bp to dangerous levels and apparently Breezula can do the same. So discouraged as this one kept me optimistic ?
Does anyone know if Pyrilutamide” or “KX-826” main component of Kintor is a steroid?
Same question as someone mentioned above. What is the outlook for grey hair reversal treatments for 2021? Seemed like we heard the most progress from Rivertown and now they are shut down.
They made a push with the University research to attract attention and dollars to move forward, but they were not able to reach their goal. Hopefully another group has something even more promising in development now.
FT, stemsontx is looking for a histotechnician to begin the pig trial. I saw a job listing
Woofy You saw it on hair loss talk:)
Yeah I did. Lol
Thank you admin for this Website and all the work that you do. No other website out there is as informative. As disheartening as this whole thing can be, I’m so grateful for this site, knowing that there are viable treatments on the way keeps me going.
Really looking to forward to triple hair and their new product.
As someone who cannot use minoxidil this looks like a great alternative. I would have never known about this treatment if not for this site! Thank you so much!
Thanks Hope! I appreciate it.
Can stemson hurry the hell up! Come on move to a human and get it out to us already fucking taking so god damn long! So frustrating.
I understand your frustration Woofy. Why do they have to trial on pigs first and not humans lol.
Yeah lol.
Hi admin, have you heard of “In Silico Trials” ? It’s a new way of conducting trials.
From what I’ve read, In Silico Trials will help tremendously to speed up progress. Then we don’t have to spend 10 years in the trial process, it can be done as soon as you find a potential solution and then go out to the public instantly
@sonic,yeah that’s the same company that has developed hair loss drug using AI(GANs). Apart from inventing medicine on their own they also help other companies in end to end drug discovery (from target identification to clinical trial to market launch),their AI technique can predict before hand if a drug will fail clinical trial or not or if it fails in which phase it will fail.The company i am taking about is insilico medicine.
Better, company use it effectively to identify treatment that would work on individual rather than product failure.
Sonic, That’s interesting
No news about the release of TH-16 in Europe?
I’m sure the European market is a high priority for Triple Hair. Between Turkey and the website I’m sure there will be a solution.
Thanks admin for the update.
Let’s hope it lives up to expectations.
Thank you Admin for the update on TripleHair! Really appreciate it.
Not that I have high expectations of the Electric Hair Cap in the pipeline but it would be something that could potentially aid I’m combination to other treatments due to its stimulating factor, hopefully they give us an update in Q1 of this year.
Thank you admin for sharing this.
Hope, I will be able to order this from India.
I want to give it a try because this will be a better option for me at young age.
Really surprisen that TH16 is so effecrive if judging the result pictures. Cant wait trying it
I guess, you should expect based on what you see in the pictures or slightly less than that.
Admin you don’t seem too impressed with triple hair. What’s your overall thoughts?
Hi Stef, for an OTC like TH16 I’m trying to help people have reasonable expectations. It’s not written anywhere that this new product is going to be a miracle growth product sprouting hairs in bald areas and I don’t think people should expect that. I think some people may not realize that creating a visible increase in hair growth from an OTC has been a bit of a challenge for years.
My thoughts about TH16 are:
If Samumed approximately has the equivalent results of Minoxidil, but just uses a different pathway, and if TH16 has claimed to have better results than Minoxidil, that means TH16 should be the best treatment we’d get this year or next year (before TH07 gets released).
Would be nice if TH16 could release their data that proves TH16 did in fact outperform Minoxidil. Seems reasonable o expect if they are so confident of their claims.
Admin, do you think when you have some time you could ask your people at Triple Hair to release their trial results against Minoxidil?
My understanding based on your update is that their done with all the trials, their just working on networking for distribution overseas now, so I don’t think it would be a problem for them to release the data.
Samumed,TH16,UW device and Mane biotech device
We have many things to come this year but we don’t have any data to backup our hopes we can only wait
Mane biotech guys are active on social media but no data I was so passionate about that Korean umbilical cord blood thing real sci-fi stuff oh man I was so sad when it’s failed even though admin had very reserved opinion on that ,my expectations was so high
@Kapil right, but I also hope for Giulliani and Gurus this year. And you never know what surpises come like some cosmeceuticals i.e. this Mangrove Tree extract or Glutamic Acid.
@John Doe I thought Giuliani is already out and Gurus yet to prove it’s worth(?) and You are absolutely right on surprises
@Kapil I think this was wrong information about Giulliani. The real product is still to come. Dr. Ralf Paus from Monasterium said its coming in his latest podcast. And I am absolutely with you concerning this Korean stem cell product. Sad it was worthless. But I still think there is more in the pipeline from Exosomes and Stemcell media even as Cosmeceuticals.
As long as Triple Hair Vice President has not more Hair I doubt they can do a lot 🙂
https://www.bio.org/events/bio-digital/sessions/674643
LOL! You have a point. You’d think the Vice President who is the “Speaker” would represent hair growth results of TH16 if it was effective.
Although, one could say that the VP was already completely bald and only people who have some hair can see some regrowth.
However, I don’t see myself buying any hairloss treatment if they can’t produce data but can only make such grand statements claiming to be better than Minoxidi . If that’s the case, any company could make outrageous claims. We’ve seen enough scammers by now to fall for just anything that’s available because we’re desperate for something.
We need to know information like how many people were in the trial, how many people experienced better results than Minoxidil, etc. Any possible side effects, etc.
Even though TH16 combination of natural substances, even Saw Palmetto has been known to give similar side effects as Finasteride (just giving an example), hence we need data.
If a solution works every company competes to work and support them but the Point is if a solution can get a 20% result they will be allowed for marketing and selling. It’s about 30 years they are so close to find a real solution ? I am optimistic for upcoming years Because I can see a competition
Fair enough, but who would expect an all natural product to grow hair on a NW7? If a company can get decent growth on NW7 from an OTC or even a prescription drug, they can charge literally $2k/bottle for it. This is not what TH16 is slated to be/do.
@FollicleThought do you have any contact with ralf paus? He was talking about developing a cosmetic topical soon linked to his current research but that has gone quiet
D1, I do have some contact with Paus, where did he say he was working on a new topical please?
@FollicleThought why are you so negative on samumed? For low norwoods and under 45 it performed really well, much better than the average
D1, I am not negative on Samumed at all, I am realistic. They did a phase 2 with 300 people and shared 0 photos from it. It’s just a curious statistic. I am big supporter/optimist/hopeholder for hair growth medicines in general, a lot of people know this. I hope for the best from Samumed, though I know what impression to give my readers about its potential.
Thanks for the update admin! Hoping that triple hair is a genuine addition to battle against hair loss.
Not sure if this is the right place, but question to the community… Took my first 1mg finasteride tablet today. Have done a lot of research and feel comfortable taking it and know what to do if I do suffer side effects.
The one thing I am unclear on, however, is dosage per week. I have seen what look like reputable sources say that 1mg three times a week/0.5mg every day/slowly increasing from 0.25 to 1mg per day is ideal. I can’t really find significant scientific research backing this up.
Currently planning to stick with the standard recommendation and continue with 1mg every day.
Thoughts and genuine reading material more than welcome!
(I’m now 30 and have been using Minoxidil for about 5 years but feel like it hasn’t been working quite as well for the past two years – hair has definitely become thinner, especially at the front. Really hoping finasteride provides a boost!)
From a long time Fin and now Dut user…take 1mg everyday. No guarantees in life but the odds (data) are overwhelming that you’ll be fine as far as side effects are concerned. You can’t find scientific evidence on the random internet prescribed lower dosages as there are none. Fin has a short half life and should be taken as prescribed to be effective.
Thanks for the response Yoda. Had made the plan to proceed with 1mg a day from the start for pretty much the reasons you’ve just pointed out. Will continue with that and in the unlikely event I do get any side effects will act accordingly.
Another finasteride-related question: is shedding pretty much a dead cert? From what I’ve read on “professional” websites the stock party line seems to be it’s expected. But people’s experiences on forums vary a lot. Also, depending on where you read the point at which shedding happens could start at any point between a few weeks and 4 months.
I think I may have shed a bit when I started Minoxidil but honestly can’t quite remember. Obviously wasn’t so bad that it’s haunted me lol
Happy to help P, good that you have an open mind. Yoda is old as dirt so my recollection is fuzzy but I don’t remember much of a shed, if any. Like you, I started minox 1st (in the mid-1980’s) then hopped on fin in the mid-1990’s, both compounded off label at the time before FDA approved for hair loss. I really don’t remember much of a shed when getting on any treatment, more recently when I switched from fin to dut. The only time I painfully remember sheds in my life is pre-treatment or when they lost their effectiveness. Hence why Yoda’s treatment protocol has evolved over the years. Unfortunately hair loss doesn’t standstill and becomes more aggressive even with treatments. Good luck P!
My good friend yoda….what treatments are you on currently and which type of minox? Can you tell me what the compound mixture ingredients. Lookikg to bump up from what I am using.
Hey MJ, still on oral minox and dut. As far as topicals I use Follics 10% minox with Bimatoprost in the am and Regrowth Labs 7% minox with dut in the pm, both have some other goodies mixed in. The dut % in the is fairly low, I might replace oral with a higher % topical dut at some point to see how it goes. I believe the oral minox is the strongest tool in my toolbox. Hope this helps!
Yoda- what dose of oral min are you on?
Also, admin… Thanks a lot for the time and work you put in to this site. I never comment but have been following this site for over a year. It’s reassuring how up to date you are and this site does feel like one of the honest ones.
Thank you P.
Hey JJ, Yoda is on 10mg once a day however part of why I take that dose has to do with also helping borderline high BP. I saw no difference hairwise between 5 mg and 10mg and you might even try 2.5mg to see how that works. There are potential sides, mainly lowering BP slightly and fluid retention, Yoda is on a diaruetic at 10mg, slight retention at 5mg and none at 2.5mg (2.5 was only for the 1st couple weeks, then moved to 5mg).
Attila Hajdu, MBA, MS Vice President, Business Development Triple Hair
Why was he not using the new treatment by himself?
He prob is using it and it doesn’t work. Lol. I mean if it worked to grow back hair you know he would use it. No man wants to stay bald. So you got your answer on the effectiveness of this treatment.:)
This is actually inaccurate Mjones.
In Attila’s own words to me “I’m married and I don’t really care about hair loss anymore” That and the fact he is likely a NW7, no topical is going to make a big enough difference for him. He would likely need a large hair transplant to recover enough density.
Yoda says never trust a man who says he doesn’t care about hair loss anymore…unless he’s Bezos’ rich! 😉
I hear ya. I’m sure he’d “press a button” to get his hair back if he could like the rest of us, but if he is indeed NW7 and married I believe his sentiment, it’s much easier just to shave your head. It is a difference from being a NW4 where you have options to restore your hair. Even the combination drug TH07 (fin, min, latanoprost) is not going to be able to recover a 7.
I think we’re on the same page Admin, it’s more the NW7 than the being married…aka his choice(s) is limited by his norwood.
Mjones..I would not pay too much attention to the fact that he is bald. TH16 is perhaps marginally effective. Better shaved than just half bald. You wont get a full head of hair back with this stuff. What concerns me is how legit the data are and if the trial participants were cheating or not.
Nevertheless I dont believe its a scam like the stem cell stuff from Korea.
Why wouldn’t they just compound this treatment with Minoxidil? For those of use already using it they could end up destroying sales for generic brands if the melatonin/resveratrol combo is effective. Would be worth mentioning to TH. Otherwise, an additional $50 per month is probably not going to be worth it for minox users.
They did compound it, the product with minoxidil in it is TH18 and it’s coming out with TH16
I wonder why we haven’t seen any results for TH18. It should be more effective than TH16. Very suspicious if their not planning on releasing any data and pictures, it would greatly drop the number of sales by Triple Hair not releasing pictures or data for any of their Hairloss products in the pipeline.
Hopefully @Admin can do something about that, by asking them to release data and pictures. It’s really in their best interests too.
Word up @Dimitri. I looked up TH18. Not sure if Admin wants links posted, but found this:
https://triplehair.ca/wp-content/uploads/2020/06/THI_Corporate-presentation_June2020_EN.pdf
I personally don’t think any natural topical would be worth the pricetag they’re likely to attach to this, but since I already pay $15 USD per month for minox I would be more willing to shell out more for a more effective minoxidil product i.e. TH18.
I disagree l am 10000000% sure he tried it and it didn’t work. He isn’t going to say I used it and nothing grew. He is going to say I dont care about being a nw7. I have 0 hope in this topical. No pics of results then it dudnt happen lol. Let’s see if SM releases some pics of phase 3, if not then they prob failed too which will really suck because I like how quick and smooth they went through trials. Plus that th18 minox fin bimapotrist and reservitsl already exists. One of those compound pharmacies in NJ creates and sells it for a few years now. I’ll try and find the link. So this isn’t anything new.
Mjones…on what do you disagree?
It is clear that this is not a cure. If a NW7 becomes a NW5 what is the point using it? That is what I was told. And indeed those people look better shaved than NW4 or NW5. They also told me ‘either full head or none’. One guy does not care at all as he has the Zidane looks. Or just look at Yanis Varoufakis…perfect. We should not generalize.
The thing is, Mjones, you’re not 10000000% sure. You don’t know. You’re just guessing. And even if you happened to be right about that, the product TH16 is an all natural compound which is being presented as an alternative/same level as minoxidil which only works in areas where hair is already growing. They’re not calling it a hair transplant alternative which can regrow lots of hair in bald areas or work for NW6/7. In the end we will find out how effective it is at its goal, but to say that if it didn’t work for Hajdu who is ~NW7 means that it doesn’t work in general is a very convoluted and misleading statement in my opinion. Thanks
Dang Mjones, if your that negative about pretty much all products/treatments why come to the site just to try and bring down everyone. Just cause some things don’t work for you, doesn’t mean it won’t work for anyone else lol be patient good things will come.
@folliclethought meant to reply to Mjones
I understand, no problem Master V.
I don’t get it. Can’t people just make up a batch of melatonin/resveratrol themselves and skip the large price tag for TH16? Is there something special about this treatment where people can’t just DIY?
Do you know the price of TH16 and/or TH18?
I’m sure you could once you see the complete ingredients list Jon. You can also make your own soft drinks or chocolate chip cookies at home, too. It’s a similar scenario.
Hi admin, what’s the possible implications of the Singapore DP cell study.And thank you for all the updates.
What is this dp cell study?
Baricitinib is First JAK-Inhibitor to Demonstrate Hair Regrowth in Phase 3 Alopecia Areata (AA) Trial
https://www.prnewswire.com/news-releases/baricitinib-is-first-jak-inhibitor-to-demonstrate-hair-regrowth-in-phase-3-alopecia-areata-aa-trial-301239291.html
The big 3 works for me which are fda approved and have worked for me for almost 20 years. I am only negative on bs companies trying to push products that dont work..
The product has not been released yet, Mjones. There’s no way for the general public to know if it works or not.
https://www.sciencedirect.com/science/article/pii/S2352512618300158
I wonder why there is no company invest on these findings. this sounds promising for both grey and hair loss. this is the kind of results we are looking for.
That’s a great find! Very impressive, almost unbelievable!
I wonder if the results persistet after the 6 months.
Monoclonal antibodies seem to become a great arm for many indications.
Hi admin. Have you gewarmd anything about TH16 recently? Their website no longer says it will release in may.
Peter, I will provide an update by the end of the month on TH16. Thanks
Thank you! Keep up the good work.
Admin, any word on when TH16 will be released?
Thanks so much!
Hi Hope, the female version of TH16 will be called “Plenty” https://plentynatural.ca/ and there is not a specific date, but I think by the end of Q3 2021 is solid.
Ok great to know it’s still a go for 2021! Thank you
Hello,
I’m looking at the TH16 before and after pictures… I noticed that their before pics are all a few millimeters larger. Why did they narrow all their after pics ? Seems like they wanted to show better results. A bit disappointed.
What do you think ?
Hello Follicle Thought. Just came across your website and was pleasantly surprised by the number of potential future treatments that might actually work. I was wondering why this page has gotten more quiet in recent months and whether that means these treatments have either not fulfilled the expectations, or if there is simply a lack of insight to the trials, or perhaps further delays due to the pandemic etc.. I‘m from Germany and just turned 24 and I would guess I’m a NW2 maybe. Started with Minoxidil but I have high hopes for alternative treatments to Fin as I‘m still able to pause further recession with only Minoxidil for now (5months in and it works relatively good so far). I think it‘s amazing of you to offer the information that you do and I‘m happy to have found this page! Best regards
Hi Herby, thanks for the kind words. Perhaps the discussion has gotten quiet because the article was published many months ago?