Aclaris AGA Report Coming Soon
Today, on June 6th 2019, Aclaris made its annual presentation at the Jeffries Global Healthcare Conference in New York City.
Eyebrow Growth To Start
Aclaris CEO Dr. Neal Walker made the presentation on behalf of his company and shared some impressive eyelash growth results. The slide is shared below and depicts the before photos on the left with the results of three individuals on the right. The eyebrow hair loss was due to symptoms of alopecia areata.
The drug trialed on these patients was ATI-502, a topical version of JAK1/JAK3 inhibitors. Hopefully these images provide hope for anyone who might be faced with, or has a loved one, in a similar situation of eyebrow hair loss.
Aclaris’ AGA Trial
Over the past year or so, many readers have been anticipating an update from Aclaris’ phase 2 trial using ATI-502 for male and female androgenic alopecia. Below are two slides from the Jeffries presentation which display information on how JAK inhibitors are proposed to work in AGA.
I have not previously seen the mechanism of action for JAK inhibitors in AGA elucidated such as this figure below. This slide proposes that JAK inhibitors are able to stimulate hair follicle stem cell activity and thus initiate anagen phase out of telogen.
According to Dr. Neal Walker of Aclaris, the company will be reporting on the AGA trial for both men and women “in the coming weeks.” This announcement was made at the 17:42 mark of the presentation which can be found on the events page of the Aclaris website. Stay tuned to Follicle Thoiught for a follow up on this clinical trial report.
Posted in Aclaris Therapeutics
So does this mean they will be going to phase 3 and market will be ideally 2020?
How can we order the Brotzu lotion? Are results gettting better?
Looks like it doesn’t work if you are 45+
I’ve been using Trinov (Brotzu) since the start of the year. It doesn’t appear to have had any effect in stopping my hair loss (which has been going on for 34 years: I am now 58 and what I have left on top is very thin). I have also been on Fin for three years, but that doesn’t seem to be working either. I am coming to the view that only hair regeneration will probably work for me: Tsuji cloning, or some sort of bio-engineering. That said, I would probably give JAK Inhibitors a go if they come on tap first. If you want to try Trinov then you have to order it from Italy. With transit costs you are talking around 100 dollars a month: so not cheap. That said, I expect hair cloning will be expensive, but if it works I will happily pay. The sooner we have it the better as am fed up with wasting money on stuff that doesn’t work and/ or plays with your body chemistry.
I have been using Trinov for 3 months now and I can confirm that it did not work for me either. Not wven for vellus hair as I’ve been hearing before.
Are they currently in phase 2 or are they planning on initiating phase 2 in the next coming weeks.
They are currently in phase 2.
New way to activate stem cells to make hair grow
no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells,” said Lowry, a professor of molecular, cell and developmental biology. “Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect.”
The team identified two drugs that, when applied to the skin of mice, influenced hair follicle stem cells in distinct ways to promote lactate production. The first drug, called RCGD423, activates a cellular signaling pathway called JAK-Stat, which transmits information from outside the cell to the nucleus of the cell. The research showed that JAK-Stat activation leads to the increased production of lactate and this in turn drives hair follicle stem cell activation and quicker hair growth. The other drug, called UK5099, blocks pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice.
Based on this clinical study there is a preliminary treatment until the completion of clinical trials is a Polish serum
This success story documents the success of the clinical study .
https://www.reddit.com/r/tressless/comments/ax60i7/my_dad_seems_to_get_his_hair_back/
Great job bringing these news for us, Follicle Throught.
What about the development of this drug for alopecia areata, any news? I’m really looking foward to that.