Dermaliq Therapeutics Raises Funds For Drug Trial – Plus Omega Tx Data
A subsidiary of a European pharmaceutical company has launched in the US to trial a new drug against pattern hair loss. Also, preclinical data from the stock market-traded company Omega Therapeutics is shown.
Dermaliq DLQ01 Drug Candidate
On January 18, 2022, Novaliq GmbH and strategic investment partners announced the formation of a Dermaliq Therapeutics Inc., a newly established US pharmaceutical company. Novaliq is a Germany-based pharmaceutical company which specializes in ocular (eye) drugs and a proprietary topical delivery vehicle. The company has apparently decided to create a separate entity, Dermaliq, to develop several drugs for dermatological conditions. One of those drugs is DLQ01, described as “a liquid drug candidate for the topical treatment of female and male androgenetic alopecia, targeting the prostamide E2 (PGE2) receptor in hair bulbs...” The press release states that $15M USD has been raised for the development of three phase 1/2a clinical programs, one of which is DLQ01.
Two FDA approved ocular drugs, latanoprost and bimatoprost, are widely recognized as having hair growth promoting properties. At this point it is not clear whether DLQ01 is actually either of them or a separate molecule. In any event, Dermaliq’s “hyliq” delivery vehicle may support DLQ01’s potential. Dermaliq plans to initiate a phase 1/2a clinical trial of DLQ01 in men in Q3 2022.
Omega Therapeutics Preclinical Data
Omega Therapeutics is a NASDAQ-listed biotechnology company which is developing a new platform of mRNA therapeutics for various conditions. Their pipeline includes targets such as corneal regeneration, idiopathic pulmonary fibrosis, and even alopecia. Through a proprietary platform which they have named Omega Epigenomic Controllers or OECs, the company seeks to control gene expression in a precise, new way. The technology is very complex and this video should help everyone get better acquainted with Omega Therapeutics.
In Omega’s company presentation on page 31, data from an experiment which was completed using human dermal papilla cells is displayed. Omega tested three different OEC sequences (specifically called EpiZips) to lower the SFRP1 gene in human DP cells. SFRP1 became popular in hair growth research following the paper published by Hawkshaw et al at the University of Manchester. In a previous webinar replay which has now expired, the CSO of Omega Therapeutics, Thomas McCauley, stated that the company is evaluating the EpiZip HFDP.08.pX.Y.Z.644 for both androgenetic alopecia as well as alopecia areata. Currently, Omega appears to be seeking strategic partners to further advance their alopecia program.
Extra News: Rise Technology Website
Preclinical research stemming from the University of Wisconsin Madison which was published in a peer-reviewed publication has spun out into the startup Rise Technology. Several readers have asked for updates on the device being developed by Rise Technology. Recently, the company finally unveiled a prototype image of their hair growth cap which utilizes a built-in nanogenerator. It seems that the product concept has not gone through human trials yet and may become available sometime within the next two years.
Thanks to reader John Doe for his continued support with news.
I hope you all enjoy the video of Omega Therpeutics which potentially has big utility outside of hair.
I think the best comment i have ever red.
Thanks for your emotions
Note: iL44 is referring to a comment from another reader with multiple expletives complaining about companies over the years going through clinical trials and lack of progress. It had to be removed. I understand the frustration in waiting for progress but unfortunately those type of comments do not help the big picture. Screaming or cursing is a bit too much, if you want to express yourself please do it succinctly and leave out the expletives.
Dear Admin,
Sory for my negative comment approval. I know nagativity brings nothing, but on the otherhand, hair researchers made us really crazy.
As Albert Enstein said, doing same trials over and over again and expecting different results
is so stupid.
I think, this quote represents exactly our hair researchers.
All researchers unfortunately have been focusing on DP cells or topic compounds.
They believe if they inject some DP cells under the scalp and hairs will be prodeced under the scalp and coming out regularly and they will solve the problem. What a unrealistic idea!they think. How can a scientist assumes and has a imagination like that. This idea must be a child idea. How the cells generate regular hair cosmetically? it is impossible guys.
They must change their point of view.
They must focus on baby’s hair rather than mice and pigs. Correct questions bring correct answers.
Why are we born with the hair and vellus?
What creates this vellus on our head?
How the vellus get thicker in motherwomb?
Does Scalp skin produce vellus and goes under the skin and catch the blood and get thicker in timeline? or vellus coming from under the scalp?
Maybe we must generate the some vellus just over the scalp not directly under the scalp.
In any case we must imitate the nature or God!!
As a human being, we can not create anything we can just imitate something!
Why dont they search monkeys instead of mice and pigs?
In any case we are relatives with monkeys.
As everyone knows some scientists believe, human were evaluated from monkeys, and religions says, monkeys were the some punished tribes. As a result of both theories, we are relatives.
Some type of monkeys suffer also a baldness problem and androgenic allopecia with the age.
We are really tired to hear “decades away” word and this funny FDA approval story.
Please guy pay attention about FDA approvment for Minox.
How useful is it and it has so much dangerous side effects but FDA did not care about that and aproved.
Actually as a cure waiters we dont want to hear about mice results, FDA awaiting, patent application, stock price, approval for licensing,
Increase hair density 2 hairs in 1 cm square,
Cumulative hair thickness, significant results with no evidence, hair pictures from any google page, jumping mice with human hair, happy pigs give us 2 decades away hopes, some funny topics cream or shampoo or holly oil any more.
From the hair scientists and follicle thought site, we are waiting perfect approaches and open and clear results, share the results honestly, not only hopes please little bit reality to keep our hopes and patients strong.
Hey Guys dont forget we are all in same boot and many are coming behind of us.
Have a nice works my all bald friends
iL44, no worries and no need to apologize for the “negative comment approval.” I simply left that note for context since the previous comment was removed.
In response to your detailed comment: I agree that mouse studies are not very useful, save for showing safety. I think the average person also underestimates how expensive mouse studies are, not cheap at all. Human tissue is typically more useful to study, but it is expensive to carry out this research as well. Monkeys are probably even more expensive to study since they need to be housed and cared for to study. In any event, all of this R&D requires someone who is willing to fund it.
I think you make some great points about your interest in studying why young humans start with thin hair and mature to thick hair, I don’t mean to keep repeating myself, but this type of research would require a lot of financial backing. Over the past 30 years investors have not lined up to be altruistic hair growth financiers and I actually find that strange. If we gave $25M to some famous researcher to dive deeper into your theory they would not say no. We would all love to hear/see more data results from companies. However, I’m not going to shout at a new company trying to crack this case just because they are coming behind 7 other companies who have not succeeded. How would that make sense if the goal is to succeed? In this case we have to wait for the information they give us, the only other option is to fund the research and development yourself. If you have some useful ideas for that I am open to hearing them.
I feel you, it’s not ideal. But honestly, in 10-15 years, we’ll probably have something like a full cure, to say nothing of the advancements that mRNA will enable for health in general. We’ll get there!
FT where did my post go about talking about Dr fargo?
Woofy97–I believe it is still there woofy, in the comments under updates.
Josh, thanks, you’re on top of things. Yes, with so many comment threads please try to keep track of where you originally posted it to avoid confusion.
Just hours after this article was published, Kintor officially announces the dosing of the first patients in their US phase 2 trial for pyrilutamide. https://folliclethought.com/updates/
By the way, just received a response from siRNAgen. They will provide some additional info about CosmeRNA within a week.