HairClone Receives Grant To Begin Work
2020 has started with some good news for people seeking hair regrowth treatments.
HairClone announced today that they have been awarded a grant from the Innovate UK organization. This grant is government funded in the United Kingdom and is awarded to innovative technologies with the potential to make an impact on the UK economy. I’m told that this grant will enable HairClone to carry out the work that they had hoped to finance with their crowdfunding campaign which took place in early 2019. The news of this grant will be welcomed by many people of our community who were disappointed that the crowdfunding did not initially meet its goal.
Here’s the tweet that was sent by HairClone today:
We are extremely pleased and proud to announce that, in partnership with Newcastle University, we have received a significant grant from InnovateUK to help us develop our personalised regenerative cell therapy for androgenic alopecia and make it ready for clinical use pic.twitter.com/bULY44bGhg
— HairClone (@HairClone) January 6, 2020
HairClone’s Work In 2020
I’ve received some additional information from HairClone CEO Paul Kemp about the grant and how it affects the development of HairClone.
- The grant was actually applied for in June 2019 and received provisional acceptance followed by a period of due diligence in September. On January 6, 2020 HairClone is able to finally make the announcement of the grant. Kemp added “These grants are extremely competitive and we are very pleased and proud to have been successful.”
- HairClone’s work will now be in partnership with Newcastle University of the UK who has a GMP manufacturing facility and a license from the UK MHRA to produce cell therapies for use as “Specials.” For more info on Specials see this previous interview on Follicle Thought.
- HairClone has begun this partnership on January 2nd which includes the following activities:
1) Carry out transcriptomic studies to identify selection of analytical techniques for male and female DP cells (HairClone can possibly use these to select for specific sub-populations and/or use as quality control assay).2) Develop commercially relevant DP cell isolation and culture system that could form basis of automated manufacturing system.3) Develop required documentation, tech transfer and validation of DP cell expansion process that could be used for the “Cell expansion service.”4) Develop mechanism of action data to support its rejuvenation and rebuilding hypothesis that has been previously discussed on Follicle Thought. - An important point of emphasis is HairClone acts as a “cell expansion service” company and does not provide treatments themselves. In the future, their expanded DP cells could be utillized by clinicians for use in the UK. Neither HairClone nor the physicians can promote this as a treatment nor claim any efficacy due to regulatory guidelines. As of now, it may take up to a year for HairClone’s expanded cell service to become available in the UK.
It’s great to hear that funding has finally fallen into place for HairClone. We are all very much looking forward to news of the first patients who receive treatment with HairClone’s expanded DP cells.
Posted in Hair Cloning, Hair Growth Treatment, HairClone, Hairloss Cure
Great news! Let’s hope this speeds things up with this type of hair regeneration technology
Thats Great News….!
Although how many times before have we seen this or something similar?
A few companies have tried cell therapies in the past (Intercytex, Aderans) however they were attempting to grow hair in bald areas with the cells. HairClone is looking to thicken and rejuvenate hair that has begun miniaturization by restoring their dermal papillae cell count through injections.
They also have ideas that their injections may convert DHT-affected hair follicles to becoming DHT-resistant follicles, though this will require testing to prove. Even further down the line, HairClone is also pursuing the “new follicle generation/cloning” technique that companies like Stemson, Organ Technologies, etc. are pursuing. Their PhD associate Summik and Dr. Claire Higgins work in this area.
What kind of FDA process and timeline would this require if the process is viable.
In order to be able to commercialise such a treatment from the FDA it would have to receive a marketing license as a Biologic from the CBER arm of the FDA. This would require clinical trial data from 2 different pivotal Phase II trials. The FDA would then need at least 18 months to analyse the data approve the license and the length of time these clinical trials would take would depend on the number of patients needed to show statistical efficacy, the number of clinical trial sites available and the amount of cash available to run the trial. The founders of HairClone have a huge amount of experience in cell therapy clinical trials and know the costs, timelines and risk involved. We have used this experience to develop a strategy involving our growing clinical partner network who hope to be able to utilise the UK regulations in order to give early access to patients which will optimise the design of the pivotal trials thus reducing the timelines and costs.
@Paul Kemp
concretely, when will it become available?
It depends what is meant by “available” Best estimates if all the work and funding goes well are 1) Available as a cell expansion service for clinicians to use in the UK from 2021. Available for patients in multi-centre clinical trials hopefully beginning 2023. Available in clinics as a marketing product would depend on the speed we could recruit for the trial, the results we obtained and the time taken by each country’s regulators to assess and approve the trial results and that last step alone can take a couple of years. I appreciate from spending my entire career in this field that the time that it takes to get marketing approval for a new medicine can take many years which is why the UK’s flexibility to enable clinicians to provide a treatment available to clinicians for patients in the interim is so attractive. I hope this helps
Paul,
Many thanks for taking the time to answer questions. It is greatly appreciated.
I think I understand what you’re saying, but it would be great if you could clarify one or two things I’m unsure of.
1) What does “cell expansion service” actually mean? Would this be a sort-of pre-release, working trial to give early access and help collect data? If patients take the treatment at that stage, are they doing so at their own risk? Like an informed guinea pig? Or will there be hard data by that stage?
2) When you say “clinicians”, do you mean people who work at hair transplant clinics? Like, say, Dr Bell at The Maitland Clinic?
3) What are the basic differences between the three stages you mention? Is the first one a pre-trial where patients can try the treatment before we really know of it works? Is the second the actual trials? Is the third the stage where you will know what works and what doesn’t?
Thanks again for all your work!
Great news! Really coming along quickly for Hairclone!
On your point of emphasis, does that mean they will grow the hair but transplant is carried out at a surgery? Or that another lab will do the growing? Thanks
David, sorry I missed your question. Hairclone grows the cells in their laboratory space and then the cells are injected by a hair surgeon at the surgeon’s office.
Come on 2020 ?? let’s go. A little hairclone injections a little way3116 I’d be a happy guy.
Would you say HairClone or tsuji has a more competent procedure? Theoretically
It’s hard to say which procedure is more competent at this stage. For starters, the treatments are aimed at two different tasks. Hairclone is seeking to thicken and rejuvenate hair and Tsuji is looking to create a proto-hair follicle and implant them in the scalp to grow new follicular units. Hopefully, both companies are competent in their approach. Tsuji’s goal is a quite lofty, but for all intents and purposes Hairclone’s goal has not been accomplished previously either. It would be nice if we find out about both of these treatments around the same time frame.
I thought that what’s the clinical trials are for? To establish treatment competency/effectiveness as well as safety. I don’t think any armchair internet bro-scientist can answer this question, probably not even an actual scientist at this juncture. BTW, nice scoop and good news Joseph!
Cheers and thanks to the tenured Yoda!
I suppose HairClone getting its grant is cause for everyone to jump for joy. As sure as the sun rises everyday, everyone will hang his/her head if HairClone’s trials fail. I can’t tell anyone what to do, but don’t count your chicks until they hatch!
In the contingency HairClone is successful, will it work for the entire range of Norwood or what?
I haven’t heard them specifically mention a norwood scale, but if you follow along in the articles the treatment is designed to thicken hair that is thinning. This would most likely work for NW 1-5ish. The biggest upside here is if follicles are converted to becoming DHT-resistant after injections.
Admin!
Thanks for your efforts! Could be available the injections this year ? An estimated cost?
Regards
I’m not sure Drago if there is a chance that injections could be possible this year. I don’t want to overestimate but it seems in the real of possible. I think the estimated costs were around 2500 british pounds.
Just to be clear here, the InnovateUK grant is NOT to run a clinical trial. The funding is to do the ground work to be able to culture expand (clone) hair follicle cells to a GMP quality that could be used in the clinic and to gain some evidence in the lab to support the hypothesis that we can rebuild miniaturising hair follicles and thus increase the diameter of the hair shaft which in a clinical setting would reverse the appearance of hair loss.
When we are able to have such a GMP manufacturing system we could offer a “cell expansion service” to clinicians under MHRA’s “Specials” provision which has been discussed elsewhere.
Of course ppl would be sad if the trial was not great, that’s not the point. You need to get to this step first to even have a trial lol. Doing a trial to find out AND having the possibility that it works is much better than no progress at all. Simple math brethren. Im rooting for Hairclone this year, I want to see fast turn around from ppl’s injections and view results.
Scientists can learn what works and what not works (and why not) only through clinical trials. That’s why these clinical trials are very important. Intercytex and Aderans failed, but scientists learned a lot from those companies why they failed. Even if HairClone don’t produce superior results it will give scientists a very clear big picture why reprogrammed stem cells can grown hair in mice, but not in humans (if they don’t success to grown hair in humans).
Hairclones strategy is to offer the treatment under a ‘specials’ license and evalute the results and tweak things iteratively as they learn what works and what doesn’t, they are circumventing the trials process. When they establish a clear protocol of what works the best, they will go through the conventionsl trials process.
Spot on Matt!
As someone said if scientists got it right the first time it would be called search rather than re-search
As I read this again, I realize…this could come to market in US without FDA approval? Could it come this year?
Do not hope for anywhere before early 2021.
No not in the US without FDA approval.
The cell treatments will be available to physicians in the UK who most likely could begin in early 2021, possibly sooner. It would be some time before this is available in the US. However, if the treatment works well, patients outside of the UK would be able to visit the UK and receive treatment from a qualified physician there.
It’s really great to see that people are becoming so knowledgeable in what we are doing. That response is 10/10
Dr. Kemp,
Thank you and your team for all you are trying to accomplish. Is this method you are researching only going to thicken existing hair, or will it be able to reverse balding for good?
The product would absolutely be regulated in the US as a Biologic and would need FDA approval. Please see my replies above as to the timings
The doubt I’ve always had is about which follicles Hairclone can rejuvenate? can you do it in the almost translucent follicles that are difficult to see? or will only be in follicles that retain their pigment but clearly look but much thinner than others? as I understand it once they lose the signaling is impossible to rejuvenate or recover. The fuzzy ones will be the best candidates? there are several questions I ask myself when reading about Hairclone
The level of pigment shouldn’t matter but from the clinical and pre-clinical data we have seen from others it seems that follicles can miniaturise “beyond the point of no return” although where that point is remains to be seen
do you know i can be involved in clinical trial here in the UK?
Maria, there will be no clinical trial. When the cell treatments are available you would need to contact a doctor in the UK who is working with Hairclone and then receive the treatment through them.
Thanks so much Follicle Thought 🙂 I was thinking of trying Regenera Activa in the next few months. What do you think in comparison to Hairclone? Sorry im not that cluely on the scientifics but are the treatments similar?
It’s a much different approach as Hairclone is multiplying the cells of the dermal papilla and Regenera just uses the cells from hair follicles and its surrounding tissue. I don’t know which one is better at the moment because Hairclone’s treatment has not been administered to patients yet. I also don’t advocate for someone to try Regenera simply because it’s a newer therapy and the decision should always be a personal one. But all in all it seems to be similar to PRP, some have had success with it and some don’t.
Thanks Admin for your honest response much appreciated. I have had PRP injections before and didnt really see a drastic difference. Would it be fair to say if PRP didnt work Regenera most likely wont work either?
I’m not sure Maria, solely on opinion I would lean towards predicting that Regenera may not produce results that impress you if you did not respond to PRP.
If people sign up to our mailing list on the website http://www.HairClone.me we will keep people informed of the status of our development and at the appropriate time how to register for a clinical trail. I should point out here that the actual clinical trials themselves (see the response above about clinical trials vs specials from Follicle thought) will be carried out at clinical partner clinics around the world
Hi Paul,
I am following your work for many years now, and there’s nobody else who I wish success more than you, after decades of research and dedication – I suppose you do it for you, but the outcome will benefit us (sufferers). Thanks for that.
I just had a major laugh, there’s really a guy on your advisory board called Jeffrey Epstein. He probably really didn’t kill himself…;-)
Take care, B.
Yes it is unfortunate for Dr Epstein who is no relative and who has suffered from having the same name. Thankyou for those kind words and I have spent all this time and effort in the area because I really believe it can work and for the first time we would be able to show that medicine could rebuild failing organs, albeit small ones! And along the way we could help millions of people suffering from hair loss which would be a win win!
Hi Paul, is the research also still going on to clone/produce new hair follicles as well as the dp cell expansion research?
@Admin Could this realistically be of any benefit to a NW6? Would we be able to increase density / thicken up existing donor hair in order to maximize transplant results? I’m trying to get a better understanding of how the procedure works.
as I was told when I contacted them, it would work to thicken miniature hair. I imagine that it is the miniaturized hair still visible with pigment and not translucent without the need of magnification to see it.
Thanks for your question. I have found that there is often some confusion over the hair thickness which I have seen used both to describe the diameter of individual hairs, the number of terminal hairs per square centimetre and the combination of this in for example a pony tail. What we are aiming to do is to recellularise and rebuild miniaturising hair follicles and return their hair shafts to their original dimension. The preclinical and clinical data that we have from other groups would suggest this is possible but that hair follicles can miniaturise beyond the point that they can be rebuilt. We would hope that once a treatment like this was established patients would start treatment as soon as hair miniaturisation was noticed and hairs would not go beyond the point that they could be repaired However, for some people this wouldn’t be possible and in those cases we think a combination of this treatment to rebuild those follicles that can be recovered and traditional hair transplantation to replace those hairs that can’t be rebuilt could provide more coverage than transplantation alone. I hope this helps to explain things
Hello Mr. Kemp.
The point of no return for hair follicles is probably not that bad. If you try to search some people that undergo a hormon therapy they get even 3 or 4 norwoods back and that for sure was not thanks to new follicle growth. I undestand, that the follicle damage can really depend on individual. However, if your treatment really rebuild the miniaturized follicles it would be amazing for low norwood sufferers.
to admin this peptide cure for baldness can you explain more please
Paul Kemp, how sure are you it will wokr to at least halt hair loss? Is there any evidence for it? I mean people getting this are essentially taking the plunge and I gues it will not be cheap?
We can not be absolutely sure until we get our own clinical experience but there is evidence from pre-clinical and clinical work of other groups that has shown that DP cells can migrate through the skin to hair follicles and can increase hair shaft diameter in miniaturising hairs. The team at HairClone and our clinical partners have committed considerable time and our own financial resources in this and we would not have done that if we didn’t have a high level of confidence in the possibility that this could reverse hair miniaturisation which is what leads to the appearance of hair loss. As to the cost, it is too early to set a figure to this and a part of this UK government grant will help determine what will be involved in GMP cell expansion
Dear Paul, is there a timeline for when you expect to go into official clinical trials in order to get FDA approval? (Just a prediction ofcourse)
@Follicle Thought @Paul Kemp What about this news?
https://medicalxpress.com/news/2019-12-hair-growth-baldness-optional.html
https://science.sciencemag.org/content/367/6474/161
Hi Someone, I covered this news on the Updates page. A brief summary is that the research is cool and that Rendl and his team are looking into drugs which prevent muscle contraction to see if this could prolong the growth phase of the hair cycle and prevent the dermal sheath from ejecting hair strands from the hair follicle.
Its very interesting. I have know of Mike Rendl for many years and the trafficking of cells during the hair cycle is fascinating. Work like this will all help us understand the hair follicle, probably to a deeper level than any other structure in the body and this must help the development of a successful treatment
I have more questions, sorry if they have been answered already, but I did not found it.
Would the treatment have to be used after some time again? Like once a year? How long it would take you to have clinics or partnership elsewhere in Europe?
Janko, treatment follow ups would be needed but the frequency of follow ups is unknown at this time. Please review this article and responses regarding when the treatment would be available. It could be 2021 in the UK.
No additional word on Pelage pharmaceuticals, Admin?
Not at the moment Baumer, just to throw out a guess, perhaps they are doing toxicology studies in mice to make sure their drugs are suitable for trials and perhaps later this year we will receive word about a clinical trial enrollment. I agree, it’s not the most fun when companies decide to be quiet.
What a breath of fresh air to come on FT and see such interesting dialogue, including Paul Kemp, a CEO of a company researching a cure. Sure beats the heck out of other sites that focus on arguing, conspiracy theories, whining, real or imagined side effects and hair transplantation. Thanks to Paul and of course to the Admin!
Thanks Yoda! We do appreciate Paul getting involved and thanks to yourself for contributing to the conversation. Comments are valuable to the community. We’re here for the best prospective treatments and banter in 2020 😉
Just a side note Joseph, you’d previously asked how I was getting along with oral minoxidil. I’m at the 5 month mark and continue to see improvement, my hair looks the best it has in about ten years since Dr. Lee was driven out of business. This also lends credence to what Paul Kemp is indicating about miniaturized follicles. I’m planning to wane myself off of RU, while I did see improvement when I added to my regime and don’t notice side effects, I’m not wild about using an unregulated chemical from China. I’ll keep you posted on how it continues to go.
Yoda have you seen any increase in body hair with the oral minox?
CT, at the onset longer body hair but not increased. My old man ear hair was growing quicker but interesting enough it’s pretty much back to the same rate as prior to oral minox. Bear in mind I’m on Dutasteride, this or Fin will blunt the body hair effect, not to mention inhibiting DHT. Without fin/dut my guess is that oral min is not a winner.
Glad to hear about the improvements Yoda that sounds remarkable for someone who has been on treatments for over a decade, congrats. Thanks for sharing.
Over a decade? I wish Admin! Old Yoda started on compounded 2% topical minoxidil off label in the mid 80’s kids, so over 3 decades…yikes! 🙂
Hey, 3 is better than one usually right? haha I didn’t want to make any assumptions, but thanks for clearing it up!
I consider myself very lucky to have lived in the SF Bay area in the min 80’s and saw Dr. Peter Panagotacos on the local news talking about an upcoming treatment from Upjohn called Minoxidil. I made an appointment right away, I was in my mid 20’s and has started hair loss had started in my late teens, it was traumatic. He was already prescribing 2% and 2% with Retin A. I was with him when he moved up to 5% minox before that was released and also fin before Merck released Propecia. Then onto Dr. Lee/Xandrox until he was driven out of business by an extortionist who reported him to the FDA. The last ten years I’d lost ground while trying different options. Thankfully oral Minox, Dut and a new line of higher strength topicals with added goodies has saved Yoda’s hair yet again! 🙂
So, which companies will provide us with products that we can buy in any Pharmacy? Don´t want to go to a clinic to be honest.
@Alonso Potential pharmacy options are SM04554, Follicum FOL-004, Breezula.
Hello Admin, you mentioned last year that a US company has a stem cell derived cosmetic in the pipeline. I can recall that you stated that the pics that you saw were promising. Any news on that product?
The competitor product NGF-574H is still not approved in Korea. Perhaps the regulator is not satisfied with efficacy results of the finished trial. So I feel thats a product we can probably ignore.
Thanks
M
MRKA, yes a US company does have a stem cell derived cosmetic in their pipeline and the pictures I saw were promising, showing slight regrowth of terminal hair on a norwood 7 male with gray hair after 3 months. The issue with that product right now is the company is working on their other clinical therapies for diseases and do not have extra money/resources to develop the hair growth product. It’s almost frustrating. At this point I’m not sure if they are still going to pursue it, but I know they would like to if they could.
Admin, you asked re our opinion about the YouTube guy that is using NGF-574H.
Well, a clear improvemen IMO. If all is legit, perhaps the topical is useful.
It appears that absorption is the key as it is with minox. His next update will be very interesting.
My understanding is that he does not use Propecia or Avodart.
Fingers crossed.
My hope is that this becomes as common as PRP and with much better results. Imagine getting injections every 1 year and it actually works.
Tissuse Update
Erol, I will have an update to share by the end of the month for sure.
I am expecting a delay due to little problems until March. Of course with March it is meant late March (31.3.2020)
This is, of course, possible Erol. I hope to get a response from Jon Knight that I can share with the blog this month. We’ll see how it goes. Starting the first hair multiplication trial in March would not be a bad outcome for all of us.
Ask him now please. I can’t find any info about the trial in the trial registry https://rctportal.niph.go.jp/en/result
Admin you claimed that TissUse trials will start in Q1 2020
What did Jon Knight told ya is the reason for the delay?
I’m currently asking if he will provide a brief quote to share with the audience to keep everyone updated. I can say he is still pursuing the trial like before.
Thank you. Looking forward to hear from you that trial starts next week
Hey Admin, what is the answer of Knight? Incant find anything about the trial in the Internet
Erol, constantly nagging admin isn’t going to make things happen faster and more than likely make him less likely to reply to you.
Chill out.
Mattt don’t you think we must know now what is going on with SHT trial?
It was fixed for December 2019 then January 2020 now Q1 2020.
I want to have at least one hope after the big silence of Tsuji and SHISEIDO.
If i could I would contact Jon Knight myself but obviously he only answers hair loss blogger
Erol, thanks for the support, I mentioned before that I hoped to provide an update by the end of the month on J Hewitt. There has been a delay, but they still appear much closer than any other company, so it should be all good in the long run.
Admin, can you tell me the meaning of life? Also how much does it cost and when is it available? Sorry, more snarky Yodaism! 😉
Haha, the meaning of life Yoda is to expand your consciousness towards the center of the Universe….or maybe navigate this world and maintain as much kindliness as possible…or something. 😉
So there is another delay of SHT trial?
Has Jon knight answered you?
Admin please Tell me about the company „J Hewitt“ i have never heard about that. Maybe it is a bust. Inhaber done my own research about the company and the only thing about i found was bad news about „j Hewitt offering Japanese only jobs“ the website looks inaktive. I can’t understand why Jon Knight never did an official announcement of the tissuse deal on his website or a press release. This hair loss research is much to big to not publicate it.
I am also wondering why Jon Knight made such big claims „starting trial in December“ „we will be much sooner then SHISEIDO or Tsuji on the market“ „we will know this year if it works“
And now he completely failed. Why he made such claims when he wasn’t sure about his clinical trial strategy?
Erlosender, J Hewitt is a Japan based medical technology company. I understand you’re a bit anxious about J Hewitt and the trial however, ultimately you’ll have to wait for the updates and the trial to begin like all of us will. Jon Knight did put out a press release when he obtained a license to trial the SHT technology. See here https://www.pr-web.com/2019/04/08/tissuse-grants-first-smart-hair-transplant-sht-license-in-japan/.
Perhaps Dr. Knight was a little quick to announce the trial starting in December, but he did this because he was engaged with a company to carry out the trials and in his mind there was a very high probability to start the trial in December. Since then he’s had to change the company who will carry out the trial and, thus, a delay has come with it. Unfortunate, but I can say I am still grateful that Jon Knight has decided to give the SHT procedure a chance, every other company in the world has passed on it over the past 5 years. It it takes an extra 4 months for J Hewitt to get into a trial I’d say this is still the best news in the industry actually.
It would be terrible
Admin,
I contacted Organ Technologies to ask some basic questions, and they responded. Here is their response:
“We are conducting research to provide patients with our technology as you have expected.
The method of recruiting clients and clinical trials or subjects are undecided now.
We hope to confirm our progress on our new HP new arrivals and media etc.
I am sorry to hear that you will respond to your expectations,
but I would be pleased if you can understand it.
We will encourage our employees to use words from you
and we will make every effort to realize it as soon as possible.”
They didn’t really answer any of my questions, and I’m not sure what most of this means, but I thought people might want to see it!
Thanks for sharing Pau, I hope the company will release some information in greater detail soon.
I don’t think that they’re not doing trials or something of that sort because just months ago, or maybe a little longer, they were giving lectures and doing interviews with journals about their upcoming treatments. I think they just want to disclose anything by replying to one of those inquiries who can be sent in by anyone. Maybe they actually tell you something if you’re a university or someone with a lot of dolla dolla. They like giving updates in March. I guess we’ll wait and see. Thoughts?
I got the exact same reply.
Pau, this is the money shot right here “The method of recruiting clients and clinical trials or subjects are undecided now.” Meaning that those who thought they were hopping on a plane this year to have this treatment should not hang their hopes on it. It may ultimately be the holy grail but Yoda thinks it’s years out if it ever materializes.
Haha Yoda, money shot. I’m glad you pointed that statement out, it also proves that the human trials have not started yet. I know there’s been a little confusion about that subject on the net lately.
Official trials for market release have not been conducted, yes. But they did do human tests though
Yes, possibly Tom. Though, “human tests” most likely means testing human cells in a dish. I don’t believe any humans have had Tsuji’s hair multiplication tested on them yet.
Admin, it concerns me when I read young guys post that they are putting all their hopes in something like this rather than perusing options that are available now. And that “something” has a projected timeline (not definitive), hasn’t entered clinical trails, doesn’t have cost projections, don’t know the potential protocol (how many treatments/visits), etc. If I’ve read “I’m saving my money and going to Japan in 2020 to be cured” one time I read it a 1000. Yoda’s advice, be hopeful but be realistic and proactive.
sorry Yoda is that the stem cell treatment your talking about
Yoda,
Glad to hear you’ve had success with oral minox. I’m 38. Diffuse thinner on top. Not started finasteride as my wife and I are trying for a baby. Would you recommend oral minox? I still have a fair amount of hair, so looking for something that will thicken my existing hair. Doc said no, but I’m going to ask a dermatologist.
Also, question for admin, Yoda and anyone else:
1) Which decent upcoming treatment is closest to release?
2) Which upcoming treatment should diffuse thinners be cautiously excited about? If any.
Hairclone is an option for a diffuse thinner if it comes out according to what they’ve been saying..
As a young diffuse thinner, I’m cautiously optimistic about hair clone. I’ve posted before about my optimism for SHT but obviously hair clone seems like it will be available first. If Hair Clone’s treatment is available by early 2021 or sometime later that year I’d be ecstatic. I’m only like a Norwood 2 diffuse but slowly and steadily progressing (been on Fin for around 8 months). For somebody like me, if expanded DP cell injection could halt my hair loss pattern, I would opt for that and a hairline transplant and call it a day. Just my two cents.
Exactly my thoughts, Lets hope they push through
I’m in exactly the same position.
Succesfully stopping any further loss would be huge.
Been on fin 10.5 months, some days I think its improved and some days I think its worse. Its frustrating.
Yoda doesn’t recommend anything, just relating my journey over 30 years and what’s worked and what hasn’t. Remember Pauly, I have 20 years on you so you might not need to take as drastic measures. Have you tried topical minoxidil? That’s where you should start before going to nuclear options. Unfortunately, in most cases without an anti-androgen like fin/dut you’ll be running in place at best.
@Yoyo I’ve heard they are not further with the FDA yet. I think a meeting to receive an IND is still planned for this year. If any update becomes available I will share.
Hey Admin, I appreciate your efforts. But if you do just a little research on them you might find out things about that company nobody of us will like.
You should be more careful about spreading information on that company. I know you might not have the resources, but in this case a background-check would be appropriate.
Anyways thanks for your work.
I agree that they are a mysterious company.
They’ve randomly blocked me on twitter for no reason, I had never interacted with them just followed them. Strange.
Their website is confusing too.
Also, they seemed to be working on something called Furoid which is lab grown fur for fashion and what not.
Makes you wonder how committed to our cause…
Ben, thanks for the support. I don’t believe I’m saying anything lofty about the company and I don’t make promises about any company. I do my best to stay prudent. Nothing is for sale to consumers and we will see over time how the company brings treatments to market or not.
I understand things have been said on other websites but those type of conversations will have to stay on other websites. We avoid the speculation here, we’re just focused on treatments. Like I said, nothing is for sale to general public and in time we will see if a treatment comes forth or not.
Yes, I read all those rumors about that company, but let’s remember something. We live in internet and social media era, so anybody can say something on internet no matter if it is true or not. Only time will tell if they are legit or not. Nobody can lie you today in era of massive informations. So, if they try to sell scam product people will find out very quickly.
The new year started very quiet. No really News since few weeks. Anyway I want to share this with you …. it makes me smile when I see that “androgenetic alopecia” is mentioned 121 times in the document. 🙂
Kintor Pharma Pipeline Shows Phase 2 and Phase 1 both to finish in 2020.
https://www1.hkexnews.hk/app/sehk/2019/101088/documents/sehk19123101996.pdf
John, thanks, I tried to email you but it bounced back. Where’d you come across the doc?
Hi Admin, my Email address works if you want to try again. But actually the site with the Kintor doc was suggested by Google. Its that simple.
BTW I saw you updated your Pipeline site for the Alopecia Drugs. I think its too short. What About all the Exosome companies (there are several with ready products or short Pipelines)? What about Medipost? Almirall Polichem? Exicure? Hope? Pelage? SCM? Guilliani? aso … Could you maybe also set up such a forecast for Cosmeceuticals? Also I think the list should be way longer. I see the potential of (at least) 30 drugs, Cosmeceuticals and devices within the next 60 months to get on the market.
Hair loss world will change rapidly over the next 5 years. 🙂
Thanks John, for now I honestly do not put much stock into exosome therapies. This can certainly change in the future if they become more refined but I really just see them on par with PRP for now. Being on par with PRP is not so bad either, but a lot of factors come into play like the price. When certain companies who are on the horizon like Pelage, Hope, Exicure announce some news this year they will make the list….the Guide list is intended to show companies who are ahead of others and (usually) already into clinical trials or trials planned this year.
What did jon Knight say?
Just out of curiosity: if Breezula is proven to stop further hair loss/miniaturization and releases by 2022, what will happen to hairclone’s injections treatment? Comparatively, this will be pretty much costly too!
I would think a lot of people would prefer injections as opposed to a topical. I’d much rather get injections potentially once or twice a year rather than having to rub a topical on every day. Plus, wouldn’t an injection be more effective as there is no chance to miss parts of your scalp or occasionally missing a day like in the case of a topical? I see the appeal in Breezula for sure, but if I can get an injection that does the same thing I’d rather do that.
@FollicleThought What do you think about this paper:
miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation.
http://europepmc.org/article/MED/29850524
HI Admin. DO you have news about the Tissuse trial?
I will post an update this week. The trial is delayed for the time being.
Hi Admin,
Can you tell us how bad is the delay ?
Cheers
Hi EzE, I don’t want to make any guesses for the company at this point and even J. Hewitt is not sure when the trial will start. They need to find a contracted clinical partner for the trial first and once this is done things should be pretty straightforward to get the trial started.
@FollicleThought Do you know anything about french company SILAB?
SILAB and the team of Professor Aberdam reveal the key role of exosomes in hair growth
https://www.silab.fr/actualite-258-silab-and-the-team-of-professor-aberdam-reveal-the-key-role–of-exosomes-in-hair-growth_usa.html
https://www.silab.fr/actualite-66-hairgenyl-trigger-hair-dynamics-to-regain-density_usa.html
Hi Someone, I’ll look into this. First I’ve heard of it.
@FollicleThought Main scientist behind this study and research is Daniel Aberdam, Ph.D., of INSERM and the Université de Paris.
You can find more about this study here:
https://stemcellsportal.com/press-releases/study-reveals-how-protein-norrin-helps-activate-hair-growth
Colin Jahoda is also part of this study.
I have read about SILAB and Hairgenyl before and they talk About Exosome Cosmetics. So my Question would be is it “real” Exosomes? When will it be available? (the Hairgenyl News already go back to 2017)
… Talking About Exosomes could you Maybe also check Exopharm, Australia (Stemcell Exosomes, products Plexaris und Exomeres)
Last 5-6 years there is very big interest about Exosomes.
This scientific research and paper is very interesting for hair loss community.
https://www.ncbi.nlm.nih.gov/pubmed/30924959
https://www.ncbi.nlm.nih.gov/pubmed/31938074
Another interesting study
I have a few questions about the approach used by Hairclone. In the presentation on youtube by Dr. Ken Washenik, who was working at that time for Aderan Research Institute, we see that the percentage of people with increased hair growth after one injection of multiplied dermal and epidermal cells was around 60%. What can explain that a relatively high percentage of people weren’t responding to the treatment, knowing that the cells injected were supposed to repopulate the lost cells within thinning hairs? Is it because that a high percentage of cultured cells for some individuals lost their trichogenic ability? How the approach used by Hairclone stands out compared to the approach used by ARI?
News for Exosomes really explode at the Moment. Admin you should really investigate more About it
What do you think About this new Released Exosome Product?
https://www.stemcellsgroup.com/global-stem-cells-group-releases-new-product-to-meet-growing-demand-for-birth-tissue-derived-compounds/
John, at this stage I would not guess that this exosome product is better than any others on the market. For now, unless a company is describing how their exosomes are tailored for hair growth I just don’t see them being an “exciting” option. They may improve hair growth marginally (similar to PRP) but I don’t see them as something that should get people’s hopes up just yet. If it is indeed possible to create specialized exosome therapies for hair growth I will interested for sure.
I recently went for my 20th PRP treatment, how desperate to continue to pay for a treatment your not sure does anything but so afraid you’ll loose hair if you stop. Anyway, the doctor offered exosome treatment. He told me it was not FDA approved, but would try it if I wanted. Also, had a couple people who were doing it with good result. Provided some pics as proof. I so want to try it , but am afraid of the unknown. I have done some very limited research “google” and have found that FDA has put out a warning to not try exosome treatment. They have had some negative results. So as desperate as I am I will continue to wait for a different more promising answer.
@John Hype for Exosomes is the same that we saw about PRP previous years. We need a lot more scientific research and clinical trials to prove that they are efficient in humans.
This Hairgenyl stuff looks interesting. Is it a topical? Anyone know what stage it is at?
@John why don’t buy exosomes and give the hairloss community a feedback. The hype about exosomes is the same when PRP was first revealed Yet the results were disappointing.
@ Anonymyti you answered your Question already … I also want more info and Trial results and before/after proof. And I dont see reasons why this info is so hard to get. Exosomes are very safe and used in humans since years. So no Need for lengthy Trials. Also there are so many companies manufacturing it and so many clinics using it. Can somebody maybe ask these companies or a hair loss clinic? I mean its not like such a secret like Tsuji.
Cure will come from highly trained scientists who works with stem cells/iPSCs, SNA, CRISPR/Cas9, 3D/4D bioprinting…Everything else is just wasting your time.
@FollicleThought I have some bad news for community.
Kyoto Univ.-distributed iPSCs found with abnormalities after differentiation
https://mainichi.jp/english/articles/20200108/p2a/00m/0na/012000c
Does this pertain to tsuji as well or has he worked around this issue? I think they said they surpassed this a few / several years ago in an update, or I could be mistaking it for something else.
@Admin Talking About Exosomes … here is something you could check right away.
Avalon Globocare is About to release Exosome Product for Hair Growth anytime soon now.
The CEO said it starts in 2nd half of 2019. Please find very interesting read and below from 2019.
“By the second half of this year, we are going to put out the first series of products of clinical-grade (stem cell-derived) exosomes for commercialization,” Avalon CEO Dr David Jin told Proactive Investors in June.
“I am very excited about this series of innovative products because we can use these for hair growth and skincare … This is a breakthrough in the regenerative therapeutic area,” he added.
https://www.proactiveinvestors.com/companies/news/901356/avalon-globocare-seeks-to-tap-the-power-of-cells-to-fight-cancer-901356.html
also in the embedded vid the most interesting paft for us starts at 2:30min
https://www.youtube.com/watch?v=PZNrGm__HG8
Important rule when trying to reach good business partner is to avoid companies, which claim amazing, next generation, innovative, futuristic products or services without any proof, sample or tests. Applied to hairloss business – if ya aint show us pics or study, we aint give ya any money.
Joseph, what do you think of this contraption and the clinical study? https://finance.yahoo.com/news/revian-presents-leading-clinical-trial-140000223.html
Yoda has the original HairMax Laser Comb that is virtually falling apart after 25-ish years but I still use it everyday. Do I think it does anything? Probably not but what the heck, it’s a sunk cost at this point so nothing to loose. The Yoda brain remembers hearing something about LED therapy for hair loss but not certain in what context. There are a lot of Laser caps, combs, etc. on the market now ,which I don’t think I’d consider buying, even if my device finally goes kaput. However, Yoda would possibly be tempted to try the Revian for 6 months to see if it even helps with the itch to start. That is, if you and others think this is truly different than the current laser suspects we already know of. I find it hard to believe their claim on the website that it has an anti-androgen effect so that’s a red flag already.
Hey Yoda, I may have to look into this a little more thoroughly, but at my first look over I don’t see anything overly compelling about it. For instance, the increase in hairs mentioned could be vellus hairs which are basically invisible hairs. The press release does not mention an increase in non-vellus hairs specifically. I’m not downing it, it’s just that it would take a considerable amount of data for me to get excited about a lasercomb. I don’t think they are useless, I think they can help prolong hair life, I’m just not sure if this new comb really represents an improvement in the baseline technology which has been popular for over a decade. But, if you’re in the running for a new comb anyways this might be an option for you.
Thanks for the feedback Joseph, my attention span is basically like a humming bird drinking an espresso, getting into the weeds on studies isn’t in my wheelhouse, even for my career in med device sales! I was intrigued by the LED aspect vs traditional lasers, that they did a study and really hit on the itch factor. Of course we know that this can all be “creative marketing” . I have no desire to buy another laser comb/device as I related I don’t think they have much effect. I’m kind of hoping mine finally craps out so I can quit using it! While Revian looks interesting I’ll probably hold off until more data, both clinical and anecdotal, comes to pass.
Hi Yoda, great find. I am interested in this mainly because the results indicate it may help scalp itching and irritation, which is an all day problem for me. The other reason I would spend the little money I make bussing tables during my senior year of college on this, is the 6 month money back guarantee. I will likely give it a try and if it helps my agressive hairloss situation the comments will surely hear about it from me.
Michael, if you have aggressive hair loss I wouldn’t put a lot of hopes into a device like this until we get more data. It doesn’t sound like you have a lot of $$$ to spare. You’d be better served (both from a financial and effectiveness standpoint) getting on Minoxidil and possibly finasteride as well. When I was a young man like you, in the same situation, they saved my hair. See my history earlier in this thread, I’ve got probably 35 years on you Sonny, just do it, if you haven’t already! 🙂
I think people need to really do their homework before going on Finasteride. There is a definite subset of people who have long term side effects. I know many of the readers here will argue the point, but each person needs to make their own decision. Losing your sexual function is far worse than losing your hair. I have been watching the site of late and am interested in developments in the science and would welcome a cure or improved treatments. But, the more I read the desperation of some the more I think that many may have fundamental self-esteem issues. I don’t say that with any humor or malice. But, if losing your hair is drastically altering your way of life or belief in yourself, perhaps one could benefit from counseling. I know that doesn’t apply to all on here, but does to some. I do wonder if most of us would be better off just trimming our hair down to a 1 on the clippers and be done with it and go on with life.
The long term side effect group for fin is kind of questionable to me. I’m not arguing at all or saying your wrong, but wouldn’t long time users be around the same age as people who start to get sexual dysfunction problems anyways? I mean, I don’t know the numbers but isn’t sexual dysfunction not that uncommon for 35+ year olds? I started fin once I found out Breezula would potentially be out so I decided to stick out a few years to save my hair with the risk of possible short term side effects. I’ve been fine so far for about 8 months but haven’t seen much growth if any. Honestly this has been a discouraging start to 2020 for the hair loss world.
Big L, way to be proactive buddy! It takes up to two years for fin to reach it’s peak. Are you using minoxidil? Fin stops the loss, minox stimulates the growth. Not guaranteed to work for everyone but it’s the best shot you’ve got. Good luck!
The data shows that the incidence of appreciable side effects from finasteride is minimal. If you go by anecdotal testimonials from random dudes on the internet as your guide then you can read whatever you want into a subject. I’d find it hard to believe that newer marketers Get Roman and Keeps would get funding, advertise and be in business if most everyone got sides from finasteride. I’m a case in point, got on fin in the mid 90’s, switched to Dut about 4 years ago. No appreciable sides, just some watery sperm at the onset. I’m 57 and have no problem getting wood, albeit not the same as when I was 18, nor 30’s or 40’s…it’s called age bucko! Sure, some get sides but not the vast majority. Many who claim sides on the internet seem to get them just by looking at the bottle! 😉
Your TissUse Update about the delay is delayed
Mark, thanks for giving me the opportunity to remind everyone about the Updates page, it’s a page that features updates. I recommend checking it once a day or as often as you can https://folliclethought.com/updates/
admin, don’t you think the launch in 2021 is too hasty now that we know it’s delayed again’ thanks
Soul, do you mean for HairClone? They have funding now to carry out the necessary work and should be well in time to begin treatments in early 2021 if all goes well in 2020.
admin, I was referring to TissUse, in the table you published it indicates that in 2021 in Japan.
Soul, it depends on how long the delay will last, if it ends being a longer delay then yes it’s likely that TissUse would not be available in Japan by the end of next year. But, if a trial could start in 1st half of this year I think it’s still possible that it could receive the provisional approval in Japan by Dec 2021. If/when trial starts I’ll try to have J Hewitt CEO address this, for now I’m sure he’s not even interested in this question and is focused on getting a trial going.
Thanks for the update on updates Admin! 😉
TissUse is complex technology. Don’t be naive that government bodies will allow technology just like that without clear prove for safety.
Hi admin, when do you think it would be possible to reverse grey hair?
Before or after hair loss cure?
Most likely after a hair loss cure I think the companies will figure out how to reverse gray hair. Perhaps when the stem cell technology achieves success in regenerating hair follicles they will also regenerate melaoncytes which give hair its color.
Admin thank you for your effort to inform us! https://dagorettinews.com/baldness-treatment-market-big-growth-daiichi-sankyo-aclaris-therapeutics-glaxosmithkline/ There isn’t smoke without fire! I hoping hearing more this year for shisheido, polarity, exosomes, 3D printing, organ tech, monasterium lab, crisp r in China, Japanese innovation centers, South Korean researches, follicum images, allergan movements, and too many wildcards!!! Happy new year! We are very close guys little more patient i am on this blog from the beginning, I am feeling it!
Thanks Mrpig for sharing the link and much enthusiasm. It’s really appreciated.
TissUse was the biggest surprise in 2019
TissUse is the biggest disappointment in 2020
@Admin please answer the question:
why you said in December 2019 to us that the SHT-trial is only delayed until January 2020?
It appears that the Admin is on trial by Stefan about the Tissue trial, man I thought the impeachment trial was rough! Really bro chill out, Admin is doing his best to convey the info as he receives. Things change, trials, FDA approvals, etc. are dynamic not static. On a related note, Admin can you tell me exactly what time Tissue will be released? 🙂
The sense of entitlement in some of these comments is crazy.
I don’t know how the admin remains so courteous sometimes.
Thanks Mattt and Yoda. Sometimes I allow the comments because some folks tend to complain more when their comment is removed and they can’t understand why 😉
In response to Stefan, all information has come from CEO Jon Knight, which is clearly stated in any article. Things did not go as he expected for the trial, so far. There is no set date for the trial to begin now, as stated in the latest official update. I’m going to continue to root for him and his company, I’d like to see the trial happen sometime soon.
I think it’s good that you allow the comments Admin, as long as they aren’t offensive (racist, homophobic, misogynistic, etc. ) or factually misleading, like some other unnamed sites do. Stefan means no harm, just seems misguided possibly by the stigma of hair loss and wanting the cure to appear sooner than the reality.
A possible mechanism has been just reported in the journal Nature of how stress turns hair white:
https://www.nature.com/articles/d41586-019-03949-8
https://www.nature.com/articles/s41586-020-1935-3
anyone heard of this cure
https://metro.co.uk/2017/04/03/new-drug-could-reverse-baldness-and-might-even-cure-old-age-6549963/
Seems Electromagnetic Alopecia Treatment is getting more and more researched … I really look forward to the Electric Cap from Madison. … here is new Research from South Korea.
https://www.mdpi.com/1422-0067/21/3/784
Is this a record for not posting new on article this blog?
Pier, I got you covered, RiverTown is back in the news for gray hair cure research: https://folliclethought.com/rivertown-featured-in-latest-gray-hair-cure-research/
you did it
I wrote the Farjo clinic in Manchester about getting my hair banked but no reply. Seems odd.
I banked with Hairclone at the end of November,
Did you manage to get hold of them yet?
I still don’t understand, do they already know how to cultivate the cells without them losing inductivity?
@admin, do you know this or have you asked them?