J. Hewitt To Trial Hair Multiplication In 2019
J. Hewitt, a regenerative medicine company from Japan, has told Follicle Thought they plan to start a pivotal hair multiplication clinical trial in Japan by the end of the year.
J.Hewitt & TissUse SHT Collaboration
In early 2019, TissUse issued a press release announcing it had granted J. Hewitt of Japan the first license to develop and commercialize its Smart Hair Transplant (SHT) technology for hair multiplication. This was great news to hear and the first communication from the company in quite some time. The model for SHT is similar to other hair multiplication therapies we are familiar with. In the SHT process 30 hair follicles are extracted from the back of the scalp, dermal papilla cells are isolated from the follicles and multiplied in culture, and this yields a sum of 10,000 “neo-papillae” which would then be injected back into the scalp. (a webpage for SHT on Tissuse’s website is no longer active after being published in 2017)
The TissUse SHT technology stems from research led by Drs. Roland Lauster and Gerd Lindner of the Univeristy of Berlin. Back in 2011, a video featuring the UoB researchers showcased their efforts in developing a hair follicle outside of the body. Since then, their work has been highly regarded throughout the industry and was also presented at a World Congress for Hair Research.
Announcement From CEO
I had the opportunity to get in touch with J. Hewitt’s CEO Dr. Jon Knight recently and he was kind enough to share a major news update with the readers of Follicle Thought (thanks to Fuji for the introduction). This is the type of news readers are waiting everyday to hear. Here’s what Knight had to say about the clinical development of SHT:
“We will start with 5 Japanese patients- maybe three men and two women or four men and just one woman but only Japanese subjects. We are planning by December of 2019 to start.
If successful, SHT can be offered to patients around the world who would come to Japan, have hair biopsies, and then return in 45 days for injection of the Neo-papilla. So we will know this year I believe if SHT is a viable treatment. It will not take years like Tsuji, etc..it will be much, much sooner.
My record for Aesthetic Regenerative Medicine is starting with PRP injections for wrinkles in humans in 2005 as the first in the world, and my goal is to do things quickly and then see the results and know if it works.”
My initial reaction is wow. This is the type of CEO that the internet hair community has been waiting for over the last 20 years. He sought out a treatment with extremely high potential and is going to put it to the clinical test immediately. No years of waiting for delayed results and no confusion about the status of a company’s progress. J. Hewitt is focused. Most readers are also well aware of the regulations in Japan which would allow for an expedited approval of this technology if it were to meet clinical endpoints after its first trial. It’s a serendipitous location for the SHT technology and could put J. Hewitt in a position no one would have predicted just a few months ago.
Bottom line, J. Hewitt is planning to trial a new hair multiplication therapy in December 2019 and the company is going to prove quickly if it works. If trials are successful, expect commercialization to follow shortly thereafter. This is among the most important clinical news that has been announced in the past several years of the hair restoration industry.
See Comments section below for Updates from J. Hewitt CEO.
Posted in Hair Cloning, Hair Growth Treatment, TissUse
Awesome news. If he keeps to his word this would surpass most of the other companies in development for 3-8 years in just one year since signing the license. J hewitt now top of the watch list.
Se sabe algo de esta técnica a estas alturas de 2021??
Han comenzado ya las pruebas clínicas en humanos?
They are still working on it Alvaro, no official updates yet. We hope for something by this Autumn.
Ojalá haya noticias de que van a comenzar las pruebas clínicas este año FT!, Aunque después pasen años hasta que puedan mejorar la técnica y comercializarla, para mucha gente desesperada sera la razón para seguir teniendo esperanza!
?
Wow, he ain’t no Histogen, that’s for sure. This is huge. Thanks for the great news!
True no Histogen and he even called out a few other companies lol. We need to get this guy his own show. I’m liking the vibe of his words though honestly, this is what us folks want to hear when we read the news. Big props for this one.
Can you ask him how long it would take to be available in Japan if the trial in December goes well?
Yes, will do. I was supposed to be hearing from him soon again as well.
both men and women! We need to hear the results of this trial immediately.
My initial reaction was the same as yours Joseph, wow! I Iike the cut of Jon Knight’s jib, he’s got confidence, hopefully it’s well founded. Could you also ask him what are their plans for other global markets, e.g. USA, Mexico, EU, etc.?
Yoda has entered the chat! Yes I will be sure to ask Jon that question in the next round-up. I agree Jon Knight is a confident guy and thinks like a consumer. Either way, he’s going to let us all know how things turn out for SHT, I’m hoping for the best like you. Would you be up for the trip to Japan if it comes there first?
This provides hope to those of us struggling with this insidious plague. Thanks for your continued efforts on our collective behalf.
Thank you RCT, much appreciated!
Admin, so is this cloning or just multiplication? (Not too familiar with Tissuse) And if proven successful, as they mentioned, it could be available like in 2020-21? Or shortly after the trial ends?
Greg, I will get more details about the procedure in the near future as it has been a long time since TissUse has shared news on their product. The launch of the treatment post-trial will definitely be covered as everyone is well excited about that potential and Dr. Knight’s eagerness to get things rolling.
When their new site launched earlier in the year, weren’t people saying that this was years away? I guess no one was taking Japan into account? Since regulation there is different.
Anyway, I’m getting less and less surprised by all the good news this year. i mean it’s GREAT and all but the technologies these people are using have been in development for a while – like the past decade and a half – and logically, now and the next few years is the approximate time over which they should be coming to fruition.
ur thinking of stemson maybe? It will be almost 2 yrs b4 stems start on clinical trial.
Sorry for all the questions but what kind of funding does Tissuse have? Private investors or a company?
No worries, I’m fairly certain that TissUse is based on all private equity at the moment. I’ve not seen a mention of a big partnered project just yet.
I wanna hear Benji’s take on this one 🙂
A couple questions FT. The article didn’t state that the research team has a method for preserving inducitvity in the cells during mass pass culture. Do they have a method of preserving inductivity in the cells during mass pass culture? Also, it sounds like they’re only using DP cells but I’ve read that most researchers are using 2 types of cells, not just 1 type of cell. If they’re only using 1 type of cell I wouldn’t expect much regrowth. What cell(s) are they using?
Dear Admin,
great news!! Thank you very much for the update!! As I live in Germany, it would be great, if a near-term breakthrough could come from here 😉
Dear Russell,
the TissUse technology uses a mix of different cells and they have a way to preserve inductivity. It is described in more detail in this publication from 2011:
“Mesenchymal, ectodermal and neuro-ectodermal originated cells from dissected human hair follicles were isolated and expanded into multiple passages. Dermal papilla fibroblasts have been kept under low adherent culture conditions resulting in the formation of dermal papilla-like aggregates. These spheroids underwent extra cellular matrix protein coating which mimics basal membrane compositions and thereby retained their inductive properties. In subsequent co-culture procedures keratinocyte and melanocyte attachment to the spheroids was forced allowing further follicular development. Ultra-structural examinations by scanning electron microscopy and immunofluorescence staining of cryo-sectioned microfollicles were performed to reveal spatiotemporal development and to characterize hair follicle like structures. Microfollicles were further integrated into full skin equivalents by dermal surface application or by integration through micromanipulation.” ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284944/ )
Best regards
Andreas
@Andreas Lutz
Yes, but this process doesn’t entail creation of ne novo follicles, they want to isolate dermal papillae multiply them and reinject back to the scalp.
Dear faust,
of course I am not 100% sure, but most probably the TissUse technology is more complicated than simply multiplying dermal papilla cells. The FollicleTought-article cites Dr. Knight with the words, that he wants to inject neo-papillae. And as I wrote: the process for creating neo-papillae based on the work of Prof. Lauster and Dr. Lindner (The scientific founders of TissUse) is explained at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284944/
Best regards
Andreas
@ Andreas Lutz
He literally said that he wants to reinject neo-papila back to the scalp. So, no follicular formation and then transplant, just multiplication and reinjection.
Andreas I notice that you didn’t say that TissUse is using DP cells. If DP cells are not involved I don’t think you’ll grow much hair.
Now it sounds like this may not involve injecting cells at all but rather implanting entire cloned follicles. It’s confusing.
Sure, I’d go to Japan if it was proven to work and would be beneficial for an old guy like me. 😉 I was to Tokyo in the 90’s, it’s a cool place. However, two trips is a bit daunting but if this turns out to be the holy grail I’ll make it happen. BTW, great scoop Joseph!
How much will it cost?
exactly, how much would this cost? Prices from companies have been all over the place and with this being so close itd be nice to know a price range.
Can someone tell me what kind of company is J.Hewitt? Are they big in Japan or just small local company? They don’t have even professional website. Do they have their own science research institute? This kind of clinical trials with only 5-6 people looks very unprofessional. How they will know that their treatment works perfectly well only based on 6 people?
J Hewitt is an established medical company in Japan, they’re not the size of someone like Shiseido but that doesn’t really matter in this case. They have a license to trial and commercialize SHT in Japan. In these cases the trials are handled by a third party CRO and a trial for 5 people with this new technology is going to be very expensive. Take a guess at the number, you’d be surprised. But, basically if you take 6 people and inject neopapilla in their scalp and you see increased hair growth on all of them then you know the treatment works. If it only grows hair on 1 you might have to go back to the drawing board. It’s pretty straightforward.
Bold statements by this man I like it! Now we will see how Tsuji will respond lol
@Follicle Thought So, how big are chances that German or Swedish man will not respond good enough to the treatment like Japanese man for example? I find this on internet:
Morphologic and qualitative differences in hair, a cornified end-product of matrical cells positioned in the center of a follicular bulb, exist among the races of Man. In general, Caucasians have the most prominent hair, Asians have the least, and Africans in between. Hairs can be divided morphologically into four major categories, namely, straight, spiral, helical, and wavy. Hairs in Asians are straight because follicles are straight, oriented as they are nearly vertical to the skin surface. Hairs in Africans spiral because follicles are curved, their base being aligned nearly horizontal to the skin surface. Different rates of growth of matrical cells along the sides of a bulb may contribute to the spiral. Hairs in Caucasians may be any of the four types, but mostly are wavy or straight.
https://www.derm101.com/inflammatory/embryologic-histologic-and-anatomic-aspects/hair-follicles/
Follicle Though about 8 posts above I included my full name. I did not mean to do that. It was an accident. Can you please remove my post with my first, middle, and last name right away? I’m really concerned about it.
If the trial doesn’t start until December 2019 it won’t finish for at least a year. Then they have to compile all the data and turn it over to the Asian regulatory agency. Then it will take the Asian regulatory agency some time to decide whether or not to allow the treatment into the marketplace early. If I’m wrong please let me know because the idea of it coming to market in 2020 if the trial doesn’t start until December 2019 seems unrealistic to me.
So are they hoping to put new hairs on their clinal test subjects and a full head of hair or just strengthen the existing and dormant hairs?
I’ll get clarity on this and other questions in the near term after I speak to J.Hewitt again.
@Admin: Thank you for this very nice update!
But now time has come to contact Lee Buckler. The trial results of RCH-01 are open to Shiseido. Please ask Lee Buckler on Twitter when he will talk to Shiseido. It is VERY important for us if both companies speak together for a commercialization in 2020. Otherwise the treatment will be lost in the ground.
I believe it’s out of Lee’s and Replicel’s hands whether Shiseido will commercialize. I think for Shiseido’s own sake they will probably set the record straight by the end of the year. I’ll reach out to Lee if nothing comes up soon.
Admin can you understand my doubts about anything that doesn’t concern press releases?
Pier what do you mean exactly? A CEO typically would not go on record with a trial time frame unless he was confident to see it through very close to his predictions.
Why does anyone have doubts. This guy is merely stating that they want to establish if they have something or not. The collaboration was confirmed back in April. This is a natural step. Plus, to have obtained a licence for human trials they must have proven safety at the very least. It may bomb out but I don’t think there is any basis to question that trials will take place in the near future. And let’s be honest it’s proper companies progressing their proposed treatments that give us a lift. Not universities feeding us a load of bs that will never come to fruition.
Agreed. I think sometimes ppl have the fear of too good to be true after waiting so long. Kinda understandable but a little out there. The ceo says theyre going to try it this year, good for him. Results will show the outcome. It sounds like this has as good of chance as any treatment and that may be why we’re hearing about it first.
Crushing it with the exclusives lately. looking out for the update on this.
Is this something that would mimic or replace the tsuji treatment? Or more like replicel?
Somebody correct me if I’m wrong but this approach kind of sounds like what Anderans was originally trying to achieve
Yes, but aderans was one of the first companies to use Dp cells and did not know about 3d culturing to retain the genetic expression to produce hair if I’m correct. This technology was still progressing several years after aderans shut down. The SHT tech is most likely a version from around 2017/2018, aderans tech around 2010.
The need for 3d culturing was well-known in the industry during the time of Aderans’ research effort.
@FT my question is ultimately the same as already uttered: where does Replicel fit into this? Is their treatment comparable? How does the DP in question differ from that of RCH01? Is Replicel out of the game in your book? What does all of this mean for us?
Hey Tony, I certainly wouldn’t want to put Replicel out of the game just yet. They are a big question mark because Shiseido is holding out on the results and it’s hard to imagine why. Some say a grudge with Replicel, or efficacy was not great. It’s still possible the trial just took longer than expected and we will be getting results by end of October. There’s a time limit on it though, I can’t see that the conjecture will last beyond the end of this year.
As far as the DP of SHT it all depends on how they culture their cells to retain inductivity. They claim to have an effective solution for this. I will try to get a brief description from TissUse to refresh and bring everyone up to date with their approach.
I think Replicel is done. They culture cells but they aren’t using DP cells and they aren’t making sure the cells retain inducdtivity. I think they’re done.
And Follicle Thought why aren’t you responding to my request for you to delete my post that contains my full 3-word name? I would like that post removed, please.
Russell your name was removed from the post when I saw your request, it’s not noticeable anymore. If you want the post removed just let me know which one it is.
Thanks for removing my full name from that post FT. That’s all I really needed.
Certain dermal sheath cells possess hair follicle inducing ability and are also able to be able migrate into the dermal papilla (when injected) and remodel miniaturized follicles. IMO, Replicel’s biggest hurdle is low funding (research on a shoestring). I’ve never been super-high on their technology, mostly because it’s not much different than Gho/ICX/Aderans (despite different cell types being used with similar inductive properties in each methodology).
@Follicle Thought Can you make in future article about Tsuji, Stemson,Tissuse, HairClone, Replicel, Follica and other companies what kind of cells or technique they are using. Which companies are more similar and which companies are quite different in technique and cells that they are using. It will be good science info.
Yes, this is a good idea. I’ll work on this.
It would be amazing if you could do this.
Hi Joseph, can he give us scientific studies that complement his treatment approach? Maybe you can ask him to explain differences between his procedure and rch-01?
faust, This is the initial scientific publication for this research as was shared by Andrea earlier. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284944/
Just about to contact the CEO for more info now.
@folliclethought So this is more like a hair transplant than like replicel?
It’s a good question. You would think they wouldn’t name their product a “Smart Hair Transplant” if it did not have properties similar to a traditional transplant. If it was just an injection to thicken hair the name would be quite misplaced, wouldn’t think a brilliant company would do this. So, they must have reason to believe it can grow new hairs.
Admin, you think that TissUse (if successful) will be competition to Tsuji and drive down their price or do you think TissUse is our of Tsuji’s league?
Even if it’s a slightly different approach it would more than likely help drive the price down. People who may be candidates for Tsuji’s treatment may opt for SHT before then and thus not be a potential customer for Tsuji anymore. Either way if J. Hewitt has a hair growth treatment offered in Japan then Organ Technologies will want to be competitive. It would be that J Hewitt would then be getting all of the attention.
The basis for the Replicel-/Shiseido approach are dermal sheet cup cells ( https://replicel.com/products/rch-01 ). This is probably different from the TissUse approach.
Best regards
Andreas
In my brief discussion with the CEO he told me after reviewing the SHT protocol he believed it had a good chance at success and perhaps more developed than techniques such as Rch-01. This is what prompted him to move forward with the product. I hope by next week or two we can get a technical description in as much as they will be willing to share.
Regarding tsuji’s price, I would like to say tje following.
We have ALWAYS said that hair loss is a multi-billion dollar industry and that research should focus on it much much more because of that. Now that things that work are about to come, we complain. There are easily 1000 people who can and are willing to afford 300k (not my case I cannot afford) to get a full set of hair. This represents 300Million and I think that this is what the person that comes with the true cure deserves to get just as starter. You can be sure that once the people that wanted to get treated in priority have got the treatmen it will lower to 50k. We should be happy about that.
This is not great news unti you hear the PRICE… everyone was excited about Tsuji until he told you it is gonna cost you 300K to buy your hair back.
Put the breaks on guys until you hear the PRICE
I think the price is not important. I remind you that 20 years ago you paid a nokia 3310 300 $ now it’s worth maybe 10 $. Ok, the medical industry is not so fast, but the competition will come, and it will lower prices thanks also to the takeover of the economy of scale.
That will take another 5 – 10 years… the price is VERY important.. people want hair solutions now now in ten years.
Price is not important? Seriously? Ask the rest of the hair loss community before you make a broad statement like that. lol
Price is very important. A cure is useless if it is not affordable!
Price is important but I guarantee if this treatment is similar to rch-01 this will not be anywhere close to Tsuji in price. Tsuji is actually cloning an organ in a lab and then putting it back in to the body. The repercussions of this for medicine in general is huge. This seems to be injecting stem cells that will ultimately create a hair follicle inside the body, if lucky. No where near as sophisticated or controlled as Tsuji. That’s of course if that is the treatment. FT will confirm all in due course. In the mean time, everyone pull your g-string out of your crack and chill. We are bald today, we were bald yesterday and we will be bald tomorrow morning.
For a full head of hair i would pay a million dollars if i have to, so 300k is not that unreasonable imo.
You are in a fortunate situation to afford a million dollars on hair restoration, so many of us wish to be in your situation. It’s not too common I believe.
Price is definitely important but of course having something that works and exists on the market is the first step.
For some reason I don’t think SHT will be in the $300k range, just an intuitive thing but we’ll find out in due time. It’s also important to add that contract manufacturing organizations can out bid each other (as in low price) if they know SHT is successful and they want to be the company that churns out a highly lucrative – high demand service.
FollicleThought could you please determine whether or not they plan to inject cells or if they plan to implant hair follicles? And could you also determine if they are using cultured inductive DP cells? It’s not clear.
It would appear that there is now some confusion as to whether this treatment involves re-injecting cells after culture or implanting follicles that are formed in a lab. We need to know if this treatment involved re-injecting cells after culture or implanting lab-grown follicles.
There are some really smart posters in this thread, can’t remember that last time I thought that to myself! Typically on the forums it’s predominantly negativity, bickering and self importance.
What is interesting to me is SHT never mentioned the need to create a “growth guide” like Stemson and Tsuji. This is the step that is potentially holding them up from doing a clinical trial, especially tsuji. So, if this method is ready to go for at least a trial it’s interesting, especially if it is designed to create new hair. Maybe it is enough to awake the dead follicles?
Now the suspense builds even more to find out the details lolz.
Whether or not it’s good news that SHT isn’t talking about hair guides depends on what they’re doing.If they’re re-injecting cells it sounds like good news but if they’re implanting lab-formed follicles that could be different. Direction and angle do matter. If they’re re-injecting cells those cells might create some new follicles but they also might just go into your already existing follicles and utilize the angle/direction of your already existing follicles. I don’t know what would happen if they’re implanting lab-formed follicles.
We need to find out if they’ll be implanting lab-formed follicles or re-injecting the cells after culture.
Admin would u mind open copy and paste ?
My English not good. Need use google photo 1by 1 translate :it”t very hard to me.
Hi Jwwww, can you use google chrome web browser which will translate the whole page for you or a browser with a translation plugin. Also you can just type in the website page into google translate and then click the link. It will give you that website translated. See this page for information: https://www.dummies.com/education/internet-basics/how-to-translate-a-website-with-google-translate/
Thz admin much better now,
admin u remember last time I ask u should I wait replicel or do the fut/fue ,finally the doctor said my hair too thinned not appropriate
I know impossible still want ask him will open more subjects for other places not Japanese?
Stay a month and go back is not problem：（
This looks very interesting indeed! … Do any of the treatments in the pipeline help fixing a bad hairline / high forehead, one has from birth on … cause in this case injecting something for regrow doesn’t work, as it was never there in the first place … right ?
It depends if the SHTs will be able to grow new hairs all by themselves in a fully bald area like you mentioned. It’s still being clarified, but the admin should have some update soon. There are approaches which try to do what you’re asking about SHT might be one of them.
This is great news. Thank you for your update.
Well I will have to apologize to @ Andreas Lutz ,I’ve just seen the study. I misunderstood “neo-papillae” as cultured (multiplied) DP cells, they are in fact neo-papilla condensates (DP+Dermal papilla fibroblasts+Mesenchymal, ectodermal and neuro-ectodermal originated cells=neopapillae spheroids)
So this is nothing like RCH-01, can you ask him what does “Microfollicles were further integrated into full skin equivalents by dermal surface application or by integration through micromanipulation” mean- Is this just a fancy transplant method?
Dear faust,
it is very nice, that you want to apologize .. I appreciate that very much!! … although it wouldn´t have been necessary, as in the special case of the Smart Hair Transplant approach I am really not sure, if I am 100% right.
As you probably know TissUse has to products: the Human-on-a-Chip-plaform and the SHT-project. I am quite sure, that they use the complete and complex neopapilla process (described in the 2011 study) for the Human-on-a-Chip platform. But it may be, that they use a less complex neopapilla-approach for the SHT-project. At hairlosstalk there is a good interview from September 2017 with many scientific and commercial questions. In the science section TissUse mainly talks about dermal papilla cells:
“It is true that dermal papilla cells once cultivated in vitro for prolonged periods of time will undergo changes (our data actually suggests they move to a more undifferentiated mesenchymal stromal cell type as they can then be differentiated along the adipogenic, chondrogenic and osteogenic lines). This change is also reflected in the loss of inductive hair growth capacities. However the inductive capacity as well as the specific genotype of the dermal papilla cells can be regained by re-establishing the natural 3D architecture of the dermal papilla. We do this by generating our so-called neopapilla using a special cell culture technique. These neopapilla very closely resemble the dermal papilla in vitro.”
So I don´t know for sure, if they use the complete neopapilla process described in the 2011 study for the Smart Hair Transplant approach … or a less complex dermal papilla cell culturing approach. Maybe Folliclethought could clarify that for us in the form of a concrete interview question?
Best regards
Andreas
P.S.: @Folliclethought: some of your questions were already adressed in the 2017-hairlosstalk-interview, e.g. the question if SHT rejuvenates dormant hair follicles or creates new hair follicles de novo and the question of Hans concerning hair colour:
“We expect the neopapilla to be able induce hair growth by two separate mechanisms:
– Rejuvenation of dormant hair follicles through injection of the neopapillae at the site of the dormant hair follicle.
– De novo creation of a hair follicle by recruiting keratinocytes and melanocytes from the surrounding tissue to the site of the injection. This is a process that would closely follow the organogenesis of the hair follicle and which we can also observe in vitro in our microfollicle model. If this 2-fold induction mechanism allows for a higher hair density has to be proven in the clinical trials by comparing SHT vs established methods.
Having the ability to control hair color would surely be awesome. As of now our focus lies on achieving efficient hair growth with our SHT method but having a robust method in place to influence hair colour would surely be an advanced step to investigate in the future.”
But of course you can ask again. Maybe they have gained new insights during the last 2 years.
Of course I wanted to write: “As you probably know TissUse has TWO products ….” not: “As you probably know TissUse has TO products …”
Sorry for the confusion.
Andreas, yes I realize they previously stated they believe it can grow new follicles and replenish weakened hair follicles but the main thing is they have not addressed how they can maintain a proper growth direction without using some sort of guide like companies have discussed lately. Also, their development has continued over the past several years. It seems like it could use more clarity at this time. There also seems to be a difference between the neopapillae and the microfollicle, so I hope I can get some explanation there as well.
so we basically have tsuji before tsuji (with better price hopefully)
Update
I’ve been in contact with the CEO again, however have not had a chance to pose questions to him yet. He is busy focusing on getting things in order for the upcoming trial. What I can say is it almost funny the amount of complexities and business interactions that go on behind the scenes and need to be sorted out for progress to continue, most of us are never aware of. However, the CEO let me know he is well committed and focused on moving this trial forward.
I’m preparing some questions to ask him which I will share here.
– Is the SHT expected to grow new hairs in bald areas or thicken existing hair?
– If new hair is grown, would there be need for a growth guide with SHT?
– Would a 5 person trial be sufficient to get this treatment approved in Japan or are further trials necessary?
– Do you have an estimated cost for this treatment at this time?
And I may ask others, if you have further questions you’d like me to potentially ask please list them below.
1: prediction this tragment what time come out for people really to use
2 will open more trial Quota for other country (best for this forum user,for not Japanese can stay japan half or one month,and go back after second part )
Hi FT,
Assuming that this isn’t a hair follicle cloning treatment and this can induce new hair growth:
How is the amount of hairs grown and location of where the hairs grow, controlled?
Good question. I’m going to try to get as much clarity on this situation as possible. I have a feeling it might take multiple questions.
After Japan, what/when are the next global markets they plan to enter, both those with a complex regulatory burden, e.g. USA and those without, e.g. Mexico.
I agree Yoda, not having to take the flight to Japan would be a wonderful thing. Mexico or US would be good options depending on the regulatory path for them.
Lots of us would fly to Japan. Keep in mind that Mexico is getting more and more unsafe plus it will take longer to get it approved in USA.
@ADMIN thank you so much for asking the CEO again!!
I have two very important questions it would be great if you add them:
– Will it be able for people with retrograde Alopecia (thinning of Donor hair) to get a successfull Treatment?
– Can you change your hair Colour with SHT?
I would be very happy if you add this twoquestions for me. The thing with the thinning on the back of the head is a big concern for many of us.
I would agree with Hans that the question regarding
– retrograde /diffuse unpatterned alopecia
Would be highly interesting.
Haircloning is our last hope
Thanks for all thar you do Admin
First Thank you very much
U are doing a great Job.
Can you ask if the new hair is DHT resistant?
Sometimes the Safe Area is not 100 % Safe (nw7)
Sry for my bad english.
And THANK YOU
second question: The original idea of Tissuse was to work with hair transplant clinics. The send the hair follicles and these can then be propagated. Does this goal still exist and if so, when can this be achieved
And maybe the Density.
Which density is realistic ?
THANKS
– Will it be able to repair FUE/FUT scars or implent this treatment in those areas?
– Expected density? Max density?
– how long until the hairs will be visible after the procedure?
– Just for Japanese or foreigners too?
– One time treatment or multiple sessions?
The scars question is very good one. Many men are living with scars and sometimes just wish they could shave their head. This could offer a hope to be able to wear a lower cut easier or not have to if one can afford it. FUT scar repair is a big deal for some.
Scalp micropigmentation does wonders for hair transplant scars.
I want hair, not a tattoo
You might want to ask him why Tissuse scrubbed SHT from their site. Or ask Tissuse people separately. Seems pretty weird to license a tech and then remove it from your site entirely.
This isn’t anything to be suspicious of. Medipost have done the same thing with ngf-574h. Tissuse and Medipost are the researchers and product developers, Celino and J. Hewitt are the businesses that will hopefully get these products through the final stages to establish the full extent of efficency, which FT has indicated is incredibly expensive and then if that is achieved, produce this in the numbers needed to sell it. Don’t stress about this.
Cheers
Thanks Welsh, that was a good example of how Medipost/TissUse are the biotechs and Celino/JHewitt are the commercialization franchises. I can understand your question though Tim, it makes sense. A few things are actually possible, if Tissuse knew that J Hewitt is going to be handling the development for SHT for a while and they don’t have much to tell consumers about they could have taken the page down temporarily to cut down on the amount of inquiries they get. Emails can add up sometimes, especially when it comes to hair loss cures ;). Also is possible they are redoing the page and will put it back up when completed. I’ll try to run it by them if there’s a spot for it, will try to do the more pressing questions first.
Yeah Joseph, I’d imagine it’s inevitable that if successful, they’d expand to other markets, just a question of when.
Keep up the good work! 🙂
Scientists Develop A Hair-Raising Protocol
https://www.asianscientist.com/2019/08/in-the-lab/scalable-hair-regeneration-follicle-stem-cells/
Thanks admin. I would agree with the Welsh Dragon if the license were worldwide but it seems from the press release, it is specific to Japan. I think of Replicel. They still have RCH-01 listed on their site. I don’t know anything from the business side so maybe that is standard? I know Replicel pulled some funny business so…there’s that.
There have been many attempts before to use cultured DP cells in trying to regrow hairs. And all of them so far failed. I wonder, what are they doing differently this time?
All pasts efforts utilized noninductive cells or the cells weren’t cultured. This time they are using cultured inductive cells. And this question has been asked and answered in previous posts on this page. Please consult previous posts because the answer to your question may already be in previous posts on this very page.
Hey Admin, will You ask The CEO about retrograde alopecia and Control of hair colour?
I might not be able to get those in the first round but at some point in the future hopefully we can get all questions tended to.
Hello Admin,
The Question „Is Smart Hair Transplant able to treat alopecia?“ is for a lot of People here very important. We Are here because our donor is Thin and we cant get a hair transplant. If we don’t know whether SHT could help US with retrograde alopecia we Can unfollow this treatment.
The question in which Country SHT Will Be commercialized after Japan is that useless. If You don’t Want to Go to Japan for Full Head of hair You don’t deserve it in my opinion. Only ask The important question please
Admin we need to know if SHT is possible for people with retrograde Alopecia/DUPA. Otherwise there will be a big disappointment for us if we have this hope
Marko, if the SHT works for people without Dupa, it should work for people with Dupa, albeit they might need to continually repeat the treatment to replenish their hair in the donor scalp area and on top. People with Dupa still have some terminal hairs which could be used in the SHT treatment even if they miniaturize over time. It would not be the worst option to repeat the treatment more frequently than users without Dupa.
Dear Ahmet and Bernie,
concerning the scar question: there are several biotech companies, that are testing new drugs for scar prevention and the breakdown of existing scars in human clinical trials, like e.g. the Canadian Birch Biomed or Scarless Laboratories Inc. based at UCLA.
Best regards
Andreas
If these companies are able to repair FUE/FUT scars this would lead to repaired skin and thus generating new follicles. Something like an unlimited donor. You sure about this?
Dear Ahmet,
the current trials are not done for FUE/FUT scars, but for keloids, hypertrophic scars, scars in trauma and burn patients. But if these new biomedical anti-scarring drugs work for these indications, they would of course also be very helpful for FUE/FUT scars. If new follicles would be generated in the repaired skin is not a major question of the current trials. So this can´t be answered now.
If you want to know more about these approaches, take a look at the company homepages. Many of my comments with links are blocked by the WordPress-comment system. So please google yourself with the company names and you will find a lot of more detailed information, also concerning their current clinical studies.
Best regards
Andreas
Andreas, one link at a time works well for the comments and doesn’t trigger the automated system. I’ve done an article myself on BirchBiomed, perhaps where you have heard of them. https://folliclethought.com/birch-biomed-therapies-for-scarring-alopecia-areata/ And the clinical trial you mentioned by Scarless Labs is here https://clinicaltrials.gov/ct2/show/NCT03880058
Ahmet, the idea of regenerating skin at the donor area is very attractive for hair transplant surgery and those who have FUT scars already. Though, it still seems a bit abrasive to cut out an FUT scar and then apply a new wound healing technology to prevent another scar from forming. But if it worked, it wouldn’t be the worst. Being able to fill a scar with a bunch of grafts would probably be sufficient for most people. If SHT did not grow hairs in scars it could at least grow hair in the donor area and then a precise FUE could be used to fill the scar in the traditional way.
Admin, I know this is kind of unclear at the moment but after Tsuji releases how much Ike do you think it’ll take the price to fall to something like 100K or less? (Considering other procedure like TissUse and Stemson or Rapunzel that could come out in the same relative time zone)
I would guess around 5 years of being on the market before it would go down to $100k.
I get it that the answers to questions that we want are very important to people but we need to stop adding questions and stop pressuring FT to get answers to every question we have in one convo with J. Hewitt. If this adding more and more questions doesn’t stop J. Hewitt could terminate communication with FT. J. Hewitt is busy. Does everyone understand that? They are trying to prep for the study we all want them to do. Please stop inundating FT with questions for J. Hewitt. He already has enough questions to ask J. Hewitt. We need to stop pressing more questions onto FT and we need to accept that FT will decide which questions need to be answered first and which questions will have to wait until a 2nd round of questions. We don’t want to become such pests that we lose our connection to J. Hewitt people. Everyone please we need to relax and let FT do what he can. Please!
For most of us the question about retrograde alopecia is very important. Is SHT possible with retrograde alopecia(slowly thinning donor)?
I think it’s definitely leaning towards the fact that if this treatment works it will work with retrograde alopecia. My thoughts are that it would strengthen the donor hair to a normal/near normal level and also replenish hair on top of the scalp as well. The worst option is the hair could weaken over time but if it’s able to be re-thickened continually this would effectively be a cure with a need to get treatments every few years. Not the worst situation in the world.
Thanks Russell. Everything will be OK. I understand people have questions and even if they do not all get addressed by J Hewitt at this time at least the questions can be shared with the community at this time. I’m only going to ask the important questions. It’s also not guaranteed that J. Hewitt is going to share much more information at this time for competitive reasons etc. They are planning on the trial which is the first and foremost important step for them. Understandably, some questions aren’t able to be answered yet and some answers are not a priority. I’ve just asked that they could help give us a better idea of what the procedure entails and what type of effects would be expected. I hope we can get just a bit clearer picture to tide us over the next few months.
HairClone announced its follicle banking service is available. However, HairClone isn’t even sure hair cloning/multiplication works. Now, this J.Hewitt-Tissuse initiative begins in December 2019. For some reason, I willing to wager that neither of them will be successful. After all, why cure something when tonnes of money can be made from snake-oil treatments such as PRP. In essence, my hopes aren’t up one bit! Anyone else?
Give me a break! I can’t imagine how you get across the street by yourself, brush your own teeth, and cook your own means.
The people who are selling the scam treatments are not the same people who are working on the real treatments so the people working on real treatments do not make money off the scam treatments. The people working on real treatments only get money if they bring real treatments to market. Are you capable of understanding this?
Don’t sweat it Russy. Logic is wasted sometimes. It’s hard to convince a few patients that ppl are actually trying to help them. Most ppl like you &I know there are ppl trying to help like JHewitt company. If it works or not well see. Like most of us say, let em try and we’ll find out in time if this is what were waiting for.
C,
I think that you have made a fair point. None of these companies really know what this type of treatment will achieve. All the evidence this far supports your opinion. However, the fact that they are entering human trials I would suggest deserves our positivity. But I have also made similar comments re other companies who are merely communicating theories. To be fair this is tangible news and could be significant. Even if it fails we haven’t had companies get this far since the 2 companies who attempted haircloning in the early 2000’s. Even if it fails in a weird way it would be a success that another company has got this far and may provide a stepping stone. Chin up C.
Why it’s price is so that expensive?
$100k is so high while hair transplant price begins from 2000 or 3000 dollar
Who said $100k for this treatment?
Nobody, but what good is any discussion without some needless drama?
Yes, from all indications through my convo with J. Hewitt so far this treatment will be much less expensive than other estimates we’ve heard so far. I don’t think it will be in the $100k range either.
@ADMIN when will you upload the answers of Jon Knight?
Thank you
He’s still contemplating what makes sense and is beneficial for his company to share right now. I’m sure he’d love to answer all the questions of the consumers but there are some things which are better left confidential for the time being. J Hewitt is in a pivotal position among all of the major companies now. Still, hopefully he will share some insight next week after consulting with his team and TissUse.
Who cares about the information they share if they’re working on something real? Their trial is going to happen in a few months and it won’t take long for results. I think that’s great info right there. If they’ve really got something on their hands (and on their heads lol) then there’s a reason they’re keeping their mouth shut. But I guess only time will tell. Although, that bold statement from the CEO is pretty promising imo.
Greg, I agree and one thing’s for sure, the CEO is sincere about putting this thing into trial. Even he said the trial will have to prove how the treatment works but it’s the best shot he and we have. As of now this is the only next-gen hair multiplication product that has announced they are seeking to start a trial right now. Organ Technologies could make an announcement any day, but J. Hewitt for now has the spotlight. As you say there is an incentive for them to be discrete for now.
@FT Looking at it from a historic perspective the years of research with dermal papilla and epithelial cells and what not have been completed already in the past decade or thereabout. Now these people are doing trials and fine turning so it’s kind of the latter part of the entire development of these new procedures I think.
@ADMIN last week you said you will ask the CEO Jon Knight new questions and get the answers in the end of the week.
My question is: Have you asked the CEO your questions like you promised and when do you expect the answers?
Yes, I’m still waiting for responses. Not going to pressure for answers at this point, unfortunately for us sometimes weeks go by fast while CEOs/companies are attending to other important business affairs. As soon as possible I’ll try to get more information. It may not be guaranteed at this point because he has to be strategic about what he discloses at this point. We will see soon. Thank you for your patience and continuing to check in.
Hi there, I work for an investment fund that would be interested in reaching out to J. Hewitt and their executive management. Could we exchange emails and get in touch with their company secretary?
FT, I wouldn’t push it. You could lose contact with him or he could scold you and I’m sure you wouldn’t like that. Please, just wait for him to respond. You don’t want to risk losing your connection with him.
To everyone else – please stop pushing FT. We could lose this connection to J. Hewitt. Please put your big boy pants on.
Any Updates ?
Hi Nils, J Hewitt is now being very considerate about the information that they put out regarding the trial. The way it goes sometimes it’s best to move a little quietly, I hope we can still get another small further update but I understand. I’m glad we at least got the initial update from him. Will keep everyone posted as I hear from him. Waiting to hear back from my last email now.
It’s almost December and there is no news from J. Hewitt about trials starting. Is it time to ask J. Hewitt if something is wrong?
Hello Admin,
I’m very hopeful of this treatment but I’m getting a little concerned regarding the lack of updates. Have you heard anything regarding the trial?
Giresh, yes the company is still moving forward with the trial in Japan, that’s all I can share for now. I hope there will be another official announcement from the CEO within the next couple weeks.
hopefully it will not disappoint us like others
ıs there any news?
Not at the moment, I will contact J Hewitt around 3rd week of January or so.
I had hair transplantation 2 times but its not successful and I don’t have a donor area will this treatment help me? Does this treatment work with existing hair? Does it give new hair?
Typical story. They create a hype before year end! And it causes investors to push more money and not ask any questions. Then! They push the trials to the next year and go silent. This tells me that there won’t be anything this year and maybe never. Same stunt was pulled by Replicel… they claim to have everything ready, but the applicator (which is the easiest part) will not be ready until end of year 2020. So that keeps their investors pushing money for another year while keeping them shut.
but the problem is also the media,
critical questions are never asked or things are generally not questioned.
I mean why Follicle thought isnt writing a article about Replicel/Shiseido and how unprofessionell they are working.
Its like China Media.
Klemmer, have you ever considered starting a blog and writing an article to badmouth those companies instead of complaining to me about it? I don’t see what is gained in such activities.
Companies do not disclose all information in their news releases and if you haven’t noticed yet, Follicle Thought typically gets companies to release more information than other hair news sites. I stay thankful for the news that comes and hope the companies can deliver on their promises, if they can’t, it’s on them and not me.
insulting comments ?
Its a joke ?
Yes Klemmer, you come here to criticize my efforts to bring news from companies, you’re not adding anything valuable to the conversation. My job is relay messages from companies who are in the biotech space and working on hair growth. If they are able to deliver on their promises, it’s up to them. If you want a blog doing criticism on hair companies you are free to start your own. That type of content does not foster good relationships with companies and does noting to help the audience. Thanks for reading/visiting Follicle Thought.
knock it off already. I get it that you don’t like hair loss but that’s no excuse for hassling FT. FT is doing the best he can to bring new info to the hair loss community.
He is mad about hair loss and taking it out on you
I’m not mad.
U guys just dont understand what i mean.
and if you badmouth companies then companies won’t talk to you anymore, especially if you badmouth companies for things beyond their control. FT it’s your job to cultivate relationships with companies rather than piss companies off. you are doing things correctly.
sure I do. you want a blog where people post hate at researchers but such a blog would be counter-productive because it would make researchers less likely to talk to us.
if we turn this into a blog to. hurl insults and hatred at researchers then researchers will stop talking to us. FT is doing the best that can be done given the common sense restraints that he has to operate within.
Thanks Russell, I appreciate it. Most of us are doing the best we can.
First of all, i hope i didnt hurt you.
In my opinion, i wasnt insulting. I just said that It could help to write it in this way, because at they end they need us too.
But i respect your way. Maybe its the bettet way.
You didn’t hurt me bud, for practical reasons I do not put much stock into internet criticism.
Klemmer, you need to wake up and smell the roses. These research groups do not need us as much as you think they do. They can stop talking to use anytime they want to and if/when their product comes to market you will still buy it. You (we) do not have the leverage that you think you (we) do. We are lucky if a research group gives us any information at all. Some research groups go dark and we all know that won’t stop us from buying their product when it comes out, if it works.
The more you post the more I think that FT is right – if you want to start a “Hate Hair Loss Research Groups” blog then go ahead and do it. See how far you get with that stupid nonsense. Oh and after you establish your blog as a hate blog against research groups then go out and try to get research groups to give you information. Please stop defending your position. It’s nonsense.
Ok can FT just please contact Knight and ask him for an update? All most of us want to know is why haven’t we heard about the trials starting when they were supposed to and what the timeline is now. Please ask him very specific detailed questions. Thanks.
I’m just as hungry for information as you are but I think FT should wait until he’s comfortable with the idea of going back to Knight for more information. It will be soon I’m sure, but we need to be patient for a little bit longer. Hang tight.
A new update has been posted on the Updates page.
Click here for Updates.
In summary, J. Hewitt went through several months of back-and-forth negotiations with the company who was going to conduct this high-tech trial and after 6 months the deal fell through. Now, J. Hewitt is left to find another suitable company who can carry out the trial and they are pursuing this. Not the best/worst news of all time. We’ll see how things go over the next few months for J. Hewitt and TissUse.
I don’t take Hewitt seriously anymore.
Fair enough, in hindsight the initial announcement was a bit premature. The guy is still putting up several hundred thousand dollars to try out a potential hair loss cure, though. I’m still rooting for him.
This makes the entire project seem kind of Mickey Mouse. Hewitt shouldn’t have publicized the trial if the company that was going to do the trial wasn’t even on board.
Thats what I mean
I don’t know exactly what you mean by “wasn’t even on board” – the company was interested, of course, in receiving the business of a commissioned clinical trial, they just happened to have requests in their contract that J. Hewitt would not agree to (such as having rights to create their own modified version of SHT after the trial was completed). So, perhaps the announcement was a bit premature like I said, but I can understand how Knight thought things would eventually be worked out and moved forward with the same company. If things moved forward like anyone could reasonably expect, no one would look back and criticize the decision.
For the company that would conduct the trial to try to get the right “to create their own modified version of SHT after the trial was completed” was a ridiculous request from the start and IMO this makes it seem like Hewitt was involving a Mickey Mouse trialing company from the start. I’ve heard of hundreds, perhaps thousands, of clinical trials. Companies contract with outside clinics to do double-blind trials all the time for the companies, and this is the first time I’ve ever heard of a situation like this where the people who would do the trial for the company demanded the right to “steal” the treatment being trialed as part of their payment. This situation is silly and it leaves me with literally no faith in Hewitt.
I understand your logical assumptions, but I don’t think you understand the context of the whole situation yet.
The company that J. Hewitt was dealing with is actually a major firm in Japan, publicly listed, real deal, etc. You and I, and most people reading this are familiar with clinical trials where a doctor makes a simple injection into a patient with a prepackaged drug, or a patient pops a pill once a day, or rubs a serum into their scalp once a day – very straightforward and simple trials. The SHT trial will entail the contracted company’s scientists to have to learn a proprietary cell culturing/preparation method and carry it out in this trial. Method is the key word, this is different than just testing a chemical in a trial. Unless the company is willing to agree to very strict non-compete/non-disclosure clauses there is not much that can be done from preventing the scientists who learned the method from making small changes or improvements in the original method and then patenting it and pursuing their own treatment in the future. This is not unheard of in the cell processing industry. So, since J. Hewitt couldn’t get solid protection for SHT in this agreement they had to move on. It’s all standard procedure for people who have much more experience dealing with these sorts of things than you or I.
Fact of the matter is if Hewitt can get the trial going by let’s say March everyone will be back cheering and praising. That’s how the game goes.
Of course you’re right.
So……. no news still… i guess there is still no trial done. Usual money funding strategy.
J Hewitt is a private company (no stock funding) and has not received any funding from licensing SHT. The CEO is trying to pay for the trial out of company pocket. I hope he gets to give SHT a shot.
I HAD high hopes ?
I wouldn’t say I had high hopes because I won’t know if it works until someone tries it, but I will say that I was excited that it was going to be trialed. And when I heard that it won’t be trialed, at least not soon, I felt big disappointment. I’m moving on from them because I have lost faith in them.
I don’t think it’s a scam but I also think it’s kind of suspect now. We’ll either hear about them doing a trial or we won’t. If we hear about them doing a legit trial we’ll all sit up and take notice but I’m not going to count on them anymore.
Of course if/when J. Hewitt gets things going we’ll all be excited about that happening but I really can’t understand why J. Hewitt would waste 6 months trying to get the cell-culturing company to agree not to use the TissUse tech. J. Hewitt should have disengaged that cell-culturing company the moment the cell-culturing company sounded iffy about that issue.
The company hasn’t released any new info yet but based on what the CEO said in his last update I think we COULD be about 3 months away from the trial starting. In his last update the CEO said that the disaster with the cell company he was trying to work with delayed things by about 6 months. Since that trial was supposed to start BY December 2019 that means that he COULD be able to start a trial by roughly June of 2020. After all, 6 months from December 1, 2019 is June 1, 2020.
Update on J Hewitt SHT Trial
So, I’ve heard from J Hewitt CEO Jon Knight today who reached out to me by email after reading some of the comments here.
He too, like everyone else is disappointed by the disruption of the projected trial timeline. But, he’s still pursuing the goal of a SHT trial in Japan and wanted me to reiterate a few things here.
For starters. most people are unaware that Jon Knight/J Hewitt literally invented PRP/Vampire Filler as an aesthetic treatment in Japan in 2005, this was verified in a court case which took place in 2019 involving two other British companies. Knight wanted to emphasize this in response to particular comments which were undermining the caliber of his company. To be fair, that treatment has now created billions of dollars in the aesthetic medicine industry. Not everyone has that on their resume.
Knight also told me that early on he had interest from 3 Cell Processing Center companies to do the trial, so, naturally he did not feel he was being too optimistic with a projected December trial date. He actually thought September was possible if not for the back-and-forth legal discussions. Knight also tells me that he feels some companies in Japan have turned him down because they did not want to be seen as helping a competitor to the big local cosmetic companies. Something to think about. I’ve mentioned it previously, but J Hewitt is a private company, is not stock listed, and literally gains no financial value for making announcements regarding the trial.
As for current status, I can say Knight is doing his best to get an SHT trial going. I think for now it’s best to leave it at that and see what comes. Interestingly, he also mentioned that he is paying attention to what Histogen is doing and thinks some good things can come from their recent business development and their new human collagen injectable. I’m hoping to get more commentary from him about that soon.
My take: I still appreciate the fact that J Hewitt has taken an initiative to potentially bring a next-gen hair growth therapy to market. I’ll continue rooting for them as long as they’re in the game. Understanding the situation that Knight was in, it makes sense to me and I think everyone understands that sometimes ‘sure things’ can unexpectedly change. I won’t blame him for that, we’re all human. I don’t believe in ridiculing someone when things aren’t going great and then smiling in their face tomorrow if they have good news for me. I think it’s also worth stating that after many years of the candidate therapy existing J Hewitt was the first company who finally decided to even give TissUse/SHT a chance. Every other pharma company and major investment firm in Europe (and worldwide) passed it up before Hewitt obtained a license. The trial that is being pursued could cost around $50k-$100k per trial subject! That’s pricey even for a 5 man trial and Knight is pursuing this with his own company’s money. I respect it. Here’s to hoping we get some good news on this subject soon.
I think this has turned more to the negative…very negative.
In the previous update it was stated that 6 months were lost haggling with the cellular company that was going to do the cellular work and ultimately a final agreement couldn’t be reached. Since the previous update indicated that 6 months were lost that seemed to suggest that the problem could be solved (presumably by contracting with a different cell company) in 6 months from the date the trial was supposed to start, which was December 1, 2019.
Now Hewitt is saying that he’s talked with some cell companies and he’s been told they don’t want to work with Hewitt because Hewitt is too small.
This means that the entire project is now up in the air, Hewitt does has not been able to find a replacement cellular company to contract with, and Hewitt does not know for sure if Hewitt will be able to find a competent cellular company that will contract with Hewitt on Hewitt’s terms.
Hi Russell, you misinterpreted the quote about companies not working with him, so I went back and reworded it. Companies are not staying away from SHT trials because J Hewitt is too small, that wouldn’t really make sense anyway as long as he had the $ for a trial, he feels they are shying away from the trial because there is a big company in town (you should be able to guess) and these CPCs may not want to be seen as helping a competitor to the big dog. It’s a politics thing. This is why it wasn’t easy to find a replacement CPC after negotiations didn’t work out with the first contact.
I don’t think there’s too much to over-analyze here it’s pretty straightforward. Hopefully J Hewitt can find a company to run the trial and we get to see what SHT is all about. That’s where things are at.
if the big company is shiseido this is pathetic, they havent released anything!
Right but if youre familiar with asian culture in general this is common. Honor, loyalty, and public image mean everything and their attitudes about it are sometimes strong. It’s a bit different than euro and north america.
why doesnt TissUse try in the UK?
They would need a partner there with $ to get things going. SHT in UK would be brilliant though, I agree.
On the other hand, it is possible the CEO could pull the rabbit out of his hat and get a competent cellular company to do the job on Hewitt’s terms. After all, that is what CEO’s do. I’m not going to rule this technology out yet but I’m also not going to pin any hopes on it because it’s up in the air.
Someone needs to get this guy Russell a chill pill, really just spouting off here on a situation that’s mostly reasonable.
You’re dating yourself Rex. “Chill Pill” is an old term from a long time ago old man. What exactly did I say that you disagree with?
@FollicleThought the UK isnt a poor country though
You’re right D1, UK is not a poor country, neither is the entire planet. But so far after 7 years only one company (J. Hewitt) is willing to put up money to get the Smart Hair Transplant into human trials. If they could find a partner in the UK that would be brilliant, I love the idea.
I don’t mind being old school Russ. I didn’t mean to offend brother, I know we’re all anxious for a new treatment and this Hewitt business is exciting if it can work. I’m not sure if I agree that everything is very negative now, but we shall see, as they say.
Yoda is offended, let’s get on thing straight…I’m the old man around here!
Yoda wisdom or babbling about this subject that I’ve stated before:
1. If it were that easy everyone would be doing it.
2. I believe the next treatments will be evolutionary like Follica, SM, etc. You know, the ones already
in phase III.
3. Cell based/cloning is still a few years out, let’s see some clinical trials and evidence before we get
our knickers in a twist.
4. You cats that think you’re jumping on a plane to Japan in the next 1-3 years, getting a
commercially available, affordable treatment for the general public and coming back with a full
head of hair are most probably deluding yourselves, unfortunately.
I tend to agree that some people have had unrealistic expectations for certain procedures over the past few years. When I think about trials happening in Japan or UK, I think that the confirmation that one of these cell based therapies actually works is exciting enough. That’s where I have a lot of my hope. Logistics on when it will be commercially available and traveling to a foreign country comes second. But depending on the country the trials are done in it could come sooner than later if they can get the all important efficacy/safety first.
That’s the big “IF” Bucko! 😉 It’s good to have hope, it keeps us going and feeling positive. In the near term my hope is for the next viable treatment to be incrementally better than what we have now and be available in the next year or two. If something else better drops from the sky, old Yoda will be one of the first in line.
Yup it’s a big *IF” Mack.
Any update from the CEO? any news about possibly securing funding for the trial? I’m guessing no because of corona?
The news is that the project may or may not proceed.
Hey Follicle Thought, could you contact the CEO & ask him if there’s been any progress on getting the trial going and could you also ask him to be as pragmatic as possible about his answer? I’d sincerely appreciate it
Hi recently balding, the commentary which has been shared in the last two J Hewitt updates is as clear as it can be right now, he is trying to get the trial going and if/when he gets something signed, sealed, and delivered he will let us all know.
I definitely understand your interest in knowing the details about the trial. We all wish it would have started by now, but all we can do is wait and see until we hear a definitive word either way.
There’s a first time for some things..
You’re right there is a first time for some things. BUT some things are odd enough that their should never be a first time for those things to happen. For example, pigs have never flown and there should never be a first time for them to do so. A cellular trialing company refusing to trial a treatment isn’t as far out as pigs flying but it is pretty far out. After all, J. Hewitt was going to pay the cellular trialing company to do the work of trialing the technology. This means that by refusing to trial the technology unless they were given the right to “steal” the technology the trialing company was giving up a job they were going to be paid to do. It seems kind of crazy to demand the right to steal the tech as part of doing the job and to take that ridiculous demand to the point of refusing to the trial seems even more ridiculous because that means that the cellular trialing company basically gave up the earnings they would have received for doing the job.
It makes very little sense.
In the end the cellular trialing company got nothing even though they could have gotten something by simply doing their job of trialing the tech. I’m starting to think that the entire story was bs. I’m not thinking that FT was behind the bs story, though. What I’m thinking is that Hewitt was jut trying to get attention or something like that.
It’s all very fishy.
A company refusing to take a job unless it happened on their terms has occurred thousands if not millions of times in the past in all industries. It would have been a lot cooler if this CPC company decided to take this job from J Hewitt, but if they declined, there’s not much that we can do about that, right? I don’t believe the story was falsified at all and I don’t approve of these types of theories to be presented on Follicle Thought, in this case especially because Jon Knight reads this blog and the only thing you are likely to accomplish is to tick him off. Maybe it would be worthwhile to detach from the situation a bit and check out someone else like Stemore.
I think the excuse for not proceeding with a trial sounds kind of contrived. I think there’s a chance that the tech simply isn’t ready for trials. I think the research team maybe has some more years of work to do in order to make the tech successful.
I’m still having difficulty wrapping my head around this situation. We all do jobs. When we go to work we don’t tell our boss that if he doesn’t give us part-ownership of his company we won’t do our jobs. I can’t imagine saying that to my boss.
Also, how does a company make money if it refuses to do jobs? Let me explain – J. Hewitt offered a cellular company money to do a job. The cell company would make money if does the job. If the cell company doesn’t do the job then the cell company won’t make money. So the cell company decides not to do the job. How does a company make money if it won’t do jobs?
If I go to the cleaners and ask them to clean my alligator suit they will take my money and clean the suit. If they don’t clean the suit I won’t give them my money and they won’t create revenue to stay in business. The cleaners isn’t going to demand to get to wear my alligator suit every other weekend as part of the deal. The cleaners is just going to clean the suit, take my money, and be done with the deal.
How does a cell company stay in business if it rejects jobs because the proprietary companies won’t let the cell company steal its’ technology? No proprietary company is going to give away its’ technology just to get a cell company to do the work that the proprietary company is paying the cell company to do. So in effect the cell company won’t do many, if any, jobs.
How does a cell company produce revenue if it won’t do jobs? No proprietor company is going to let the cell company steal its’ technology so the cell company won’t make deals to do cellular work for proprietary companies. So how does the cell company create revenue?
I suppose the cell processing company picks their spots. Apparently they must have other types of revenue/activity to stay in business.
I wonder what TissUse thinks about all of this. I think TissUse could start looking for another partner if J Hewitt can’t get the job done.
On the other hand, TissUse might be cutting J. Hewitt some slack because of the Coronavirus but Tissuse does have an interest in seeing their tech move forward.
One thing to remember, TissUse is not limited to one partner. J. Hewitt is a Japanese licensee of the SHT tech.
Did you mention this before? Is any other company moving forward with TissUse tech?
I haven’t mentioned it before, but in the nature of licenses, they are specific to geographic areas. J. Hewitt has a license for SHT in Japan. I do not know if there are other companies moving forward with TissUse at the moment but it is always a possibility. Stay positive bro, good things will come from somewhere.
I understand the problem with the previous Cellular Processing Company (CPC) which was meant to have started the trial on the 1st December 2019. But wow! It’s already mid-October and it’s soon to be an entire YEAR without beginning the trial.
It’s not a case where TissUse/J. Hewitt doesn’t have the money to conduct the trial. So why is it that in been almost an entire year and J. Hewitt hasn’t been able to find a single CPC that is willing to the trial in the entire massive Japan. Surely theres quite a few CPC’s in Japan.
If I’m not mistaken, to be ready to trial your product means that the product is ready and that you’re just waiting to conduct the trial. Meaning, J-Hewitt mainly has only 1(ONE) job, that is to simply find a CPC in the entire Japan. It’s been almost a year and he hasn’t delivered an available CPC to TissUse to conduct the trial.
So either, there’s absolutely no CPC in Japan for TissUse to use (which is hard to believe that not a single CPC will accept them even though they have the money to pay for the trial) or TissUse need to partner with someone other than/in addition to J-Hewitt who can deliver them a CPC.
Also admin, as a suggestion, if they really are unable to find a CPC in Japan (which they should have been able to determine by now), could you please contact TissUse and/or J.Hewitt to tell them to try to find a CPC in another country (process of elimination – obviously eliminating Japan) and try their utmost best to find a CPC in the UK. You mentioned you love the idea of the UK. I won’t believe TissUse/J. Hewitt still cannot find a single CPC in the whole of Japan and the UK.
Now is the time to be pro-active
I don’t know the whole story Sonic and I can see why you would think it’s easy to find a CPC to conduct a stem cell based clinical trial, but I will say this, unless you have experience conducting cell-based clinical trials in Japan I don’t believe you understand thoroughly what the situation can be like.
Regarding the UK/elsewhere idea: J Hewitt is only interested in Japan as it is based in Japan. TissUse would need a partner in the UK or elsewhere who wants to license and conduct the trial, every company in the world with the $ to do it is welcome to do some business with TissUse to make that happen. Not all of the time, but most of the time people who work in these industries know as much or more than those of us getting the news from them.
its 2021 now 😀 same game as with Riken. No trails because i guess the science behind them does not work actually.
Actually, for the record, the trials have not started because there has been a challenge to find a cell processing center to do the trial, and lately there are still societal restrictions going on in Japan. The trial is what is needed to determine whether the science works.
Any update?
Sn, all I know for now is that J Hewitt is still working to create a trial. If any formal updates come I will post another article.
Just a suggestion, if I may admin:
Since J.Hewitt only wants the trial to be done in Japan yet you mentioned CPC’s in Japan don’t want to do the trial for TissUse since it would be as if their supporting a competitor of the bigger companies in the market. It’s also been almost a year (which is a really long/sufficient time to find out if there’s any available CPC’s in Japan) and there’s been no breakthrough regarding a CPC. Logically that should mean that Japan isn’t the place to conduct the trial. TissUse already has the product/method, they just need to find another partner now who is willing to fund their trial in the UK (next best country).
Could you please suggest to TissUse to direct their marketing to all other international countries so that they can find a partner/s who will fund their trial in the UK? If we’re being positive, they may even find a better partner than J.Hewitt who is prepared to do a more comprehensive trial than merely just on 5 people.
I feel TissUse being limited to J. Hewitt, which is Japan-bound, severely slows down the process because clearly there’s no CPC’s in Japan willing to do the trial.
Furthermore J.Hewitt, as you say, is a private company which is prevents funding from other sources. This is a major limitation to a company with such potential.
I’ve already seen someone from the comments in this very page saying that they work for an Investment Fund Company and that they would like get in contact with TissUse to fund them.
I believe TissUse should keep their options open now for new partners and they should work on upping their marketing game so that they can get the funding they need from as many other sources as possible. It would help investors if they simply work on a company website for starters. It greatly limits funding because if I type “TissUse” into Google, I find nothing about the company except on your website. You can’t really expect funding or people to take a company seriously if people don’t even know TissUse exists because they don’t even have the basics such as a website.
Admin, you do a better job of Marketing TissUse on your website than TissUse/J. Hewitt is due to no website. Maybe you could give them some pointers.
Once again please get in contact with TissUse and ask them to work on these things.
A non-update from J Hewitt: “Please tell anyone following SHT that in Japan due to this ‘pandemic’ it is impossible for me to get any cell facility to do new work. Impossible, I was told until this is finished and everything is “normal”.
Hi Follicle Thought,
I see that you moved TissUse quite far down the list. In the Ultimate Guide your estimate of launch was 2024. Since the news came out are you still optimistic about the treatment?
It all depends on a trial starting. Right now they are stagnant and have been for a while. I will update their projection date soon.
Companies doing what they can to make something happen > people just criticizing and speculating on the internet. Give these guys a break and show some respect for their efforts.