New Company: Triple Hair

Follicle Thought is pleased to present an exclusive look at a newcomer in the hair loss treatment industry, Triple Hair of Canada.

Triple Hair’s Story

Triple Hair was founded by Dr. Houfar Sekhavat, an opthalmologist based in Moncton, Canada. It was Dr. Sekhavat’s own experience with androgenic alopecia which lead him to seek out a superior formulation for preventing hair loss and regrowing hair. After reviewing scientific literature on the subject, Dr. Sekhavat teamed up a local pharmacist, Dr. Ford, to test a new topical formulation using two of the well known anti-hair loss drugs and a third that was more obscure. After testing different concentrations and combinations, the team identified “TH07” as the ideal formula.

I recently caught up with the Triple Hair team to get more information on the molecules used in TH07 (which have not been disclosed online until now) and other company endeavors. Below, I will take a deeper look at the Triple Hair company including some Q&A’s I completed with them.

Triple Hair TH07, TH16, & More

FT: Can you tell us more about the 3 drugs in TH07 and how the company
chose them for the formula?

Triple Hair: There are over 80 million people suffering from hair loss in the United States and androgenetic alopecia accounts for greater than 90% of hair loss incidents. Androgenic Alopecia is a multifactorial disease and no single molecule can address the different pathways involved in the etiology, which is primarily due to hormone metabolism and excessive response to androgens. Therefore, the androgen receptor remains an important target for a safe and effective treatment.
The motivation behind Triple Hair is to redefine the market by launching the first new treatment for alopecia in over 40 years with TH07. Demonstrating the efficacy and safety profile in a phase 3 clinical trial will drive significant uptake of TH07 and fill a large unmet need for patients.

Scientific Rationale and Synergies
Topical finasteride provides localized treatment for hair loss with reduced systemic adverse events. Many studies have shown similar therapeutic effects when compared to the 1mg tablet form. Finasteride decreases dihydrotestosterone (DHT) and upregulates SULT1A1 which activates the pro-drug of minoxidil into its active form – minoxidil sulfate.

Minoxidil is a potassium channel blocker that was initially developed for the treatment of hypertension. Hypertrichosis was noted as a side effect of treatment and the product was repurposed as a hair loss therapy. It acts by widening the blood vessels which allows more oxygen, blood and nutrients to follicles thus promoting the anagen phase. Minoxidil increases prostaglandin E2 (PGE2), which increases prostaglandin F2 alpha (PGF2a).

PGF2a analogues have shown positive stimulatory effects on hair follicles and also stimulate conversion from telogen to anagen phase within 7 days. Furthermore, PGF2a analogues increase insulin growth factor 1 (IGF-1), which inhibits hair cell apoptosis and maintains the anagen phase. TH07 contains a patented topical formulation of minoxidil, finasteride and a PGF2a analogue. We have completed a proof of concept phase two clinical trial which showed the overall treatment effect of TH07 was 100% of patients experienced hair regrowth versus 50% regrowth for finasteride versus 25% regrowth for minoxidil. The results are summarized in the tables below:

TH07 Before And After Images

 6 month result 

6 month result, different man from the first photo. Significant regrowth.

6 month result

Triple Hair is also developing a formula called TH16 which is planned to launch as a natural consumer product into the Canadian marketplace in Q1 2021. The product consists of two natural ingredients. A randomized, double blind clinical trial showed that the overall treatment effect of TH16 was better than the comparative monotherapies. The results are shown in the table below:

TH16 Before And After Images

6 month result

3 month result

3 month result

FT: I read on your website about one of the Triple Hair products making
hair appear a bit darker, can you elaborate on this?

Triple Hair: The darkening of hair was an observation from our phase 2 clinical trial, is likely due to the PGF2a analogue in our formulation and the synergistic effects of minoxidil and finasteride. The manifestation of PGF2a analogues includes increased hair growth and pigmentation.

FT: Ideally, when will TH07 be approved for marketing in Canada and US?

Triple Hair: We are planning to begin a pivotal phase 3 study in Q3 2021 and are actively seeking partnerships with big pharma for the global launch of the product. (Editor’s note: If a phase 3 were to begin in Q3 2021, an estimated market release is in the range of Q2 2023.)

Potential industry partners may contact Triple Hair’s VP of Business Development Attila Hajdu – ahajdu@triplehair.ca

Commentary And Links

For those of you looking for more information on PGF2a analogues, a quick visit to Wikipedia will reveal that two examples of these drugs are Latanoprost and Bimatoprost. Both have been used experimentally for hair loss in the past, with Bimatoprost even entering major hair growth clinical trials with Allergan. We can be almost certain that the third ingredient in TH07 is either Bimatoprost or Latanoprost, with a slight edge to Bimatoprost.

While the new flagship drug of Triple Hair contains ingredients we have seen before, the idea of combining them and using them synergistically in a topical formula is progressive and commendable. The concept of combining known ingredients is natural and thankfully this startup has taken the initiative to actually get it done.

A point I would like to emphasize here is I believe Triple Hair is setting an important example to the industry and I hope others will take note. Pattern hair loss has proven to be difficult to treat and it is unlikely that any single molecule will produce significant hair loss prevention / hair regrowth on its own. We can see in the photos that TH07 is capable of some worthwhile regrowth. The idea of combining multiple molecules that act on different mechanisms makes a lot of sense and I believe the future of hair growth medicines will be based on combination formulas. 

An interesting bonus tidbit about Triple Hair, the company has two other molecules in its pipeline – “TH0c” and “THcb1”. TH0c has even completed a phase 1 study. A corporate presentation of Triple Hair from March 2020 is available here. I hope you’ve all enjoyed this article and feel free to leave your feedback below.

155 Comments

  1. Follicle Thought on April 15, 2020 at 4:13 pm

    I’m glad to have this news for you all at such a time in the industry and the world. I hope everyone is doing well. Thanks to Triple Hair for sharing this exclusive info with the readers of Follicle Thought. As always its appreciated that you cite Follicle Thought if sharing the news.



    • Tiar on April 21, 2020 at 2:00 pm

      Salve admin complimenti come sempre … bisogna vedere anche hewitt speriamo che trovi un partner al più presto !! Tsuji non so’ li manca la fase test su l uomo … 2025 mi sembra troppo … sempre se le cose sono regolari… anche perché ad oggi si è dimesso e il motivo non si sa’ …



  2. Baumer on April 15, 2020 at 4:16 pm

    Admin, if I’ve understood this correctly, this is just a compounded version of topical finasteride + minoxidil?



    • Follicle Thought on April 15, 2020 at 4:27 pm

      No, that’s incorrect. Article mentions minoxidil + topical fin + PGF2a analogue (either Bimatoprost or Latanoprost) The combined synergy is proposed to create better results than the 3 drugs used separately.



  3. Tom on April 15, 2020 at 4:33 pm

    I love the sound of this new product, but I have had permanent side effects from Propecia, so I’d be afraid to try it again, even if it is just on my scalp and not a pill.



    • Greg on April 15, 2020 at 4:48 pm

      Tom, are your side effects from topical or oral, and what age did you get on it? (If you’re comfortable sharing that)



      • Tom on April 15, 2020 at 5:04 pm

        Hi Greg, I started Propecia when it first came on the market…I think around 1997. I was 19 at the time. I took it for about 11 years. The side effects actually got worse after I stopped taking it. I’m finally beginning to see some improvements 12 years after stopping it, but I’m definitely not back to 100%.



        • Tom on April 15, 2020 at 5:05 pm

          They were from taking it orally, by the way.



        • Yoda on April 15, 2020 at 5:16 pm

          If you’re talking “sexual” side effects, it could simply be age. Not sure what “100%” means.



          • Tom on April 18, 2020 at 2:45 pm

            Oh no, these problems definitely weren’t the gradual effects that come with aging. This was more like a complete shutdown within a couple of months.



        • Ken on April 16, 2020 at 11:00 am

          Did you try anything to get better in that time span? Chlomid, HCG,…? Tribulus,…?



          • Tom on April 18, 2020 at 2:47 pm

            Yes, all of those and then some. I went to a doctor that specializes in PFS (post finasteride syndrome) patients. He had a lot of different things to try, but he said it’s very hit or miss. Some patients see some improvements and some are even much worse off than me.



  4. glgl on April 15, 2020 at 4:36 pm

    Thanks for your work!
    Unfortunately this will most likely have the common side effects, even when used as a topical, so im not willing to use it. The results do look good though.



  5. Vince on April 15, 2020 at 4:39 pm

    Thanks for the update admin! Interesting indeed, any idea if topical finasteride is already available? Thanks



  6. Dimitri on April 15, 2020 at 4:45 pm

    Will this make TH16 the first fda product to be released for angrogenic alopecia since minoxidil?



    • Follicle Thought on April 15, 2020 at 4:57 pm

      Dimitri, TH16 will be an OTC/cosmetic product.



      • Dimitri on April 15, 2020 at 4:58 pm

        Isn’t rogaine the same?



        • Follicle Thought on April 15, 2020 at 5:00 pm

          No, rogaine is minoxidil. TH16 is 2 natural ingredients and T.H. is additionally going to sell a version with minoxidil mixed in also.



  7. D1 on April 15, 2020 at 5:01 pm

    i swear there was a study that finasteride goes systematic when applied topically



    • Follicle Thought on April 15, 2020 at 5:10 pm

      It’s true that topical finasteride still comes with some risk of side effects, I think Triple Hair may reword the sentence.



  8. D1 on April 15, 2020 at 5:10 pm

    the TH16 is quite interesting, was hoping that Guiliani could do something similar



  9. Tina on April 15, 2020 at 5:21 pm

    Would a female have any side effects from trying this product when it comes to market. I for one would like to give it a go…



    • Follicle Thought on April 15, 2020 at 6:30 pm

      Hi Tina, which product are you referring to? TH07 is not intended for women because of topical finasteride but there are cases that doctors will prescribe topical finasteride to women as well.



      • Maria on April 16, 2020 at 6:00 am

        HI Admin what about TH16 for females ?



  10. Yoda on April 15, 2020 at 5:22 pm

    Nice scoop admin! Not super excited at this point, seems like existing biotechnology wrapped up in a tried, true package. Slightly evolutionary and a long time to market, but we’ll take what we can get. Who knows, if this is released in three years we could still be waiting and waiting and waiting for anything else more evolutionary, let alone revolutionary, to come to market.



    • Follicle Thought on April 15, 2020 at 5:40 pm

      Thanks Yoda! I realize you have most of these ingredients in your regimen for a long time, but there are a lot of younger guys and/or newcomers who will appreciate the packaged topical product and inclusion of extra stimulator like Latanoprost/Bim when it comes to market. Combining this with microneedling / dermaroller seems like a big hit for sure.



  11. Tore40 on April 15, 2020 at 5:47 pm

    Nel 2023 rilasciato ? Mi sembra ancora troppo lontano !! Speriamo che ci sia qualcosa prima!! Grazie comunque admin



    • Follicle Thought on April 15, 2020 at 6:28 pm

      Perhaps if the company finds a partner sooner they can begin trials sooner. Maybe can begin a trial in Q1 2021 which would have the release date in 2022. These are the purposes of doing the article that they can connect with industry partners. I will ask more about this when I talk to Triple Hair representative again.



  12. dg on April 15, 2020 at 5:51 pm

    This stuff is still the best we can do in 2020? Kill me now



    • KD on April 15, 2020 at 6:33 pm

      Some count blessings, others count complaints



      • Yoda on April 15, 2020 at 7:53 pm

        True KD, also some call a product a failure before trials have started or concluded, while others count their chickens before they’re hatched. It’s an odd world sometimes, I’ve always found middle ground to be the best place. Although some would argue that’s boring, I like it just fine, for you Seinfeld fans, “Even Steven”! 🙂



  13. Follicle Thought on April 15, 2020 at 8:00 pm

    I’d also like to invite people, if you enjoy the content please consider making a contribution to this site, even a $2 or $3 monthly donation goes a long way and is appreciated. Thanks very much, the link is below. https://www.patreon.com/FollicleThought



  14. Mark on April 15, 2020 at 8:19 pm

    blah blah blah… we’ve all heard this before many a time – you can find templates for such miracle cures on google – group of Dr’s discover something groundbreaking, kept it secret, now releasing it, it’s going to be amazing but wait another 5 years. Anyone remember Dr. Brotzu with his ‘lotion’ and the fantastic disappointment it turned out to be….

    What we need is something which has been developed, mass tested with proven significant results. Not something ‘groundbreaking’ which is just a formulation of existing prescription drugs tested on just 29 or 40 subjects! (that’s worse than the ‘79% of 14 women agree’ claims on make up commercials). And their 6 before & after pics – really?

    The more of these I come across the more I’m convinced the people involved are only interested into springboarding themselves into a comfy six figure salary with fat annual bonus for life in a top pharma company which will have them and their ‘amazing’ discovery to chip away at the $12.4bn hair loss market.

    Anyone who stumbles upon or develops a genuine treatment or cure will put their time & effort into proving it and treating people and documenting the process and results. Not producing corporate presentations. A proven working treatment will bring the corporate giants knocking at your door.



    • Follicle Thought on April 15, 2020 at 8:37 pm

      All due respect to your opinion Mark, but this isn’t really labeled as groundbreaking, it’s just an improvement on existing options. Also doesn’t really compare to Brotzu because Brotzu used natural ingredients and TH07 uses 3 drugs that we know beyond doubt to grow hair, 2 moreso than the third, yet the whole point is to combine their use simultaneously and get a benefit. As far as mass testing goes, 2/3rds of this drug are beyond mass tested and Bimatoprost has definitely showed promising results on its own in the past. Also, 5 years?



    • C on April 15, 2020 at 9:01 pm

      Mark, well said! Of course, being in agreement with you will get my comments removed by the administrator. If I don’t share the enthusiasm for a product that doesn’t seem highly promising, I am deemed negative and censor worthy!



      • Follicle Thought on April 15, 2020 at 10:30 pm

        Actually C it’s just I am bored of your comments, they are a bit repetitive now, no matter what the news is. Take a little break from the comments and come back later maybe, also consider helping out through Patreon.



        • Yoda on April 16, 2020 at 6:59 pm

          I looked into this Joseph, is it possible to contribute once at a time without a reoccurring monthly charge? I found that to be prohibitive in my mind.



          • Follicle Thought on April 16, 2020 at 8:48 pm

            Yoda, the way it works is you can sign up for a “monthly” donation but can cancel your account once your first pledge has gone through. You receive a confirmation email as soon as you are charged your first time unlike with most subscriptions, so it is very simple to cancel and make it a one-time pledge. Moreso, I am able to refund or cancel pledges as well, so it is ensured you will only pay the one time fee if that’s what you choose to do. Thanks for asking!



          • Follicle Thought on April 17, 2020 at 8:00 pm

            I received your one-time donation on Patreon, Yoda. Much appreciated, thanks very much.



  15. J on April 16, 2020 at 1:46 am

    This compound is already available from some clinics in the United States. I received it from McGrath Medical in Austin Texas. I did unfortunately get the typical side effects from finasteride. I would be really interested to try a version of this with just Minoxidil and PGF2a, no finasteride.



    • Follicle Thought on April 16, 2020 at 8:13 am

      I like the idea of Minox + Bimatoprost too, J! So, Mcgrath is selling a formula with Bimatoprost in it?



    • Devit on April 16, 2020 at 12:13 pm

      Hello J,
      Can you please tell me what is the side effect of topical fin?
      Is it same as with oral medicine?



      • Yoda on April 16, 2020 at 7:07 pm

        Side effects vary from person to person however I feel the the reports of this on the internet are overblown, according to the actual data. There are people that get side effects just because they are known to exist. I’ve been using topical fin (in Minox) for over 20 years, no issues. I also take oral, however I have switched to Dut for both oral/topical these days. That will make the “everybody gets side effects” crowd head’s explode! That’s ok, they’ll blame that on fin as well! 😉



        • Devit on April 17, 2020 at 12:06 pm

          Thanks Yoda for the reply.



    • Yoda on April 18, 2020 at 5:09 pm

      You bet Admin, keep up the good work and also running a forum devoid of the typical BS found on other hair loss sites!



      • Follicle Thought on April 18, 2020 at 5:40 pm

        I appreciate that for sure, Yoda.



  16. MRKA on April 16, 2020 at 2:04 am

    It sounds something promising may appear in the not so distant future.
    The comparison data with minox is interesting.

    But lets be hopeful that Applied Biology releases this year AB-103. The minox enhancing product may be beneficial for many dissapointed minox users.

    I feel that is the best bet this year.



    • Arsenal on April 16, 2020 at 7:01 am

      good point MRKA.

      Admin, any update on the AB-103? I was most looking forward to this since im a minoxidil non-responder



      • Follicle Thought on April 16, 2020 at 8:13 am

        Arsenal, I will reach out soon and get back to everyone on that in the near future.



  17. Andrew on April 16, 2020 at 4:40 am

    Hi admin, any update with Rivertown and their rt1640 product? I’m excited to see how they are getting on? Thanks



    • Follicle Thought on April 16, 2020 at 8:28 am

      Haven’t heard anything in a little while due to the corona stall, I will report back if I hear any news.



  18. Jeffrey on April 16, 2020 at 11:10 am

    TissUse Update!



    • Follicle Thought on April 16, 2020 at 1:14 pm

      See the Updates page for a nice new mini TissUse update ?



  19. Abdulaziz on April 16, 2020 at 11:28 am

    Any update on Dr Tusuji?



  20. Maria on April 16, 2020 at 12:08 pm

    And HairClone?



  21. Stephan on April 16, 2020 at 2:18 pm

    Such a mess that topical finasterid has the same sideeffects…makes the treatment worthless to me…though pictures seem really promising… Makes it even worse for me) i still thank you very much for the Article FT! Hope the haircloners hurry up, people start getting more desperate from AA in times like these, when your look makes 80 % of social life)



    • Follicle Thought on April 16, 2020 at 4:29 pm

      I know what you mean Stephan, but this is only the beginning of combination treatments, in not too distant future you could theoretically get a similar combination from a compounding pharmacy with Breezula swapped in for finasteride.

      Future combinations seem great, imagine Samumed SM + Bimatoprost + Breezula.



  22. malik on April 16, 2020 at 2:41 pm

    Hello everyone,

    I think it could be useful to write an article about Hairstetics, a company that has developed a new system of synthetic implants that has proved its worth (0 infections or inflammations after 10 months). This system is beginning to be used well as a complement to a hair transplant. Admin, I have received some photos and I think that you can ask the CEO of Hairstetics who will be happy to share his results with you.



    • Follicle Thought on April 16, 2020 at 4:24 pm

      I’ll take a look Malik, for now this system only looks available to women.



    • Paul on April 17, 2020 at 1:35 pm

      Malik,

      This seems interesting. I have e-mailed them, too. I asked some questions, and I asked for pictures. Has anyone else heard of this? If this is possible for males, could this possibly be a way to “keep us going” and visibly improve density for a few years? My questions and concerns:

      1) Is it possible for males?
      2) Does it damage the scalp or potentially lead to more loss?
      3) Are the clamps (I think that’s what they’re called) visible at the hairline?
      4) What sort of density can be achieved? On the website, the “after” pictures were much better, but the woman’s hair looked as though it had been combed to cover any scalp or diffuse areas.
      5) How often would this need re-done?

      My cynical side says this probably won’t lead to anything, but worth looking into it.



      • malik on April 21, 2020 at 11:41 am

        Hello Paul,

        I was able to contact them by phone, the product is fully available for men even if the EU authorization was requested only for women (that’s why there is no picture of men).

        Moreover, the product is completely safe unlike the old synthetic implants (Nido and Biofibre), there is almost no risk of rejection.

        The only problem is the price 10 euros per implant. A priori, the implants can completely cover a gallbladder area, and can very well complement a hair transplant.



  23. D1 on April 16, 2020 at 2:58 pm

    @Follicle Thought I dont understand the latest TissUse product. What were they proposing before that must be less advanced?



    • Follicle Thought on April 16, 2020 at 3:38 pm

      These hair culturing techniques are always a work in progress. It’s a version 1.0, 2.0 kind of thing. Also, science journal articles are sometimes published 1-3 years after the original study took place. We’ve assumed that TissUse has continually been working on their cloning work since the presentation at WCHR 2015 and launch of their website, but to see a published study is great sign/confirmation.



      • Mt on April 16, 2020 at 4:48 pm

        Does this have an impact on j hewitt’s clinical trial?



        • Follicle Thought on April 16, 2020 at 4:55 pm

          I don’t think it would.



  24. LouiSarkozy on April 16, 2020 at 5:35 pm

    do you have any clues on what could be the “naturals ingredients ” in thh 16 formula? seems unbelievable that i could bit minox 5 in term of result tbh.

    and what about side effects when it comes to using prostaglandine analogue https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991179/



    • Follicle Thought on April 16, 2020 at 8:51 pm

      Loui, I believe the ingredients are melatonin and resveratrol. Side effects from scalp use of prostaglandin analogue seem unlikely.



  25. Hairguy on April 16, 2020 at 6:47 pm

    Looks interesting but not sure why it needs such lengthy trials for approved topical. I used him, fin and minox. Saw no increased benefit so I stopped bim. Too expensive. I know numerous compound pharmacies that have these three compounds mixed. The before and after pics were not impressive at all. You would think after 40 years we would have a treatment that could fill in a balding diffuse crown. Let’s see what SM, Follica and CB can do together once they all get approved.



    • Dante on April 16, 2020 at 7:32 pm

      lol @ the comment ‘the before after pics were not impressive at all’. they were basicaly like small hair transplant results. def impressive for topicals



  26. Abdulaziz on April 17, 2020 at 5:41 am

    Any update in Dr Tsuji?



    • Follicle Thought on April 17, 2020 at 10:49 am

      Nope, I think Tsuji is doing fine, still leading the hair follicle project at Organ Tech is my guess.



  27. LouiSarkozy on April 17, 2020 at 11:31 am

    thank you so much for your answer it’s always nice to have someone like you bringing great new content about hairloss during this difficult period for the hairloss industry.

    do you have an idea what could be the mechanisms behind th16 that make it in theory more potent than minox 5 ( melatonin inhibit dht i think but what does revestravol do i’m not sure )? seems hard to believe than some natural product could me more efficient than the growth stimulant goat minox.



  28. Paul on April 17, 2020 at 1:37 pm

    Admin, thanks for this article. Seems quite promising. If the results are as good as they seem in the pictures, I would be interested in this.

    Good work!

    Also, I contacted Paul from Hairclone. Would you like me to share his response?



    • Follicle Thought on April 17, 2020 at 1:40 pm

      Paul, can you email me his response first? thanks



    • Mattt on April 19, 2020 at 6:09 am

      I’m curious to know what news you have from Hairclone



    • Maria on April 19, 2020 at 3:57 pm

      Hi Paul,
      Do you send the mail to the admin? I really like to know their answer.

      Thank you for your research !



      • Follicle Thought on April 19, 2020 at 8:05 pm

        This was the message that Paul received from HairClone: “Thanks for your email. Yes, you are right that the Coronavirus has affected our work and our timelines and will continue to do so for a while. All the clinics that we work with have closed so we are unable to obtain any tissue for our research, but even if they weren’t, the labs at Birmingham University are also closed and the GMP facility that we are partnered with in the grant is in Newcastle University and has converted to work exclusively on NHS testing. In the meantime we are not just completely stopped, and are instead adjusting what work we do when and concentrating now on the regulatory documentation aspects that we had originally scheduled for the back end of the project. We are also looking to recruit some male and female volunteers who can supply us with a few miniaturising and non-miniaturing hairs as soon as the clinics and labs re-open so that we can try to catch up some of the lost time as to date we have just been requesting samples from patients undergoing treatment.”



  29. Rudolf on April 18, 2020 at 2:44 am

    Admin can you please explain me I think i didn’t get it right: J Hewitt has problems to find a cell processing center doing the trials because nobody wants to work with them because of SHISEIDO???



    • Follicle Thought on April 18, 2020 at 5:34 pm

      Rudolf, basically the theory I have been told is that at least some of the CPCs want to avoid being involved with a potential competitor to Shiseido. But things can always change..



  30. Arsenal on April 18, 2020 at 9:16 am

    Admin,

    I had a question I was thinking about lately. Why is it that Follica has to go through the three phases of clinical trials, if they are not actually brining a new drug to market, but merely stabbing our scalps? Do microneedling devices need to pass through clinical trials before release? PRP and Exosomes are already available, but without trials.

    not making sense to me



    • Follicle Thought on April 18, 2020 at 5:37 pm

      Arsenla, I am not sure but I don’t think Follica has done the 3 sequential trials like most drugs or therapies do. We are sure that the treatment trialed in Follica’s first trial is not the treatment being trialed now. This leads me to the hypothesis that Follica is actually doing some sort of a modified trial route to get the latest treatment approved. I think it may only need one trial for approval and will be in a similar category to PRP, because remember there is no new drug being introduced here it’s just the procedure being done at the office.



  31. John on April 18, 2020 at 4:00 pm

    Admin, do you have more info about Kerastem? Looks like its already available in Europe and now has finished Phase 2 in USA (with 17 percent increase) Thats quite amazing compared with the 8 percent hype of Replicel …

    https://www.prweb.com/releases/kerastem_publishes_successful_us_phase_2_hair_growth_clinical_trial_results/prweb17051434.htm

    http://kerastem.com/product-pipeline/



    • Follicle Thought on April 18, 2020 at 5:40 pm

      Hi John, yes Kerastem and similar treatments have been available in different countries for a long time. Even adipose stem cells were available in the US for many years until recently. As far as I can tell there are no good sources of evidence that show the treatment is very effective, the procedure involves liposuction and typically produces results similar to PRP, hence it does not drum up a lot of discussion online.



      • John on April 18, 2020 at 5:50 pm

        Oh thanks for your prompt answer! … One more! 🙂 What is the Status with Celino / Medipost ?? They finished the Trial last year summer and seems to be already available in Asia or Arabic countries. Is there something in the Pipeline for Europe / USA ?



        • Follicle Thought on April 18, 2020 at 5:54 pm

          I actually don’t know that but if I hear from Jay from Celino anytime soon I will let you know.



  32. Ahmed bekeer on April 19, 2020 at 9:38 am

    Cotsarelis, George
    METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL
    http://www.freepatentsonline.com/y2020/0101000.html



    • Follicle Thought on April 19, 2020 at 11:01 am

      Definitely hoping that Corsarelis will put some of these patents to good use someday. When Follica’s new WNT topical enters trials to be combined with their wounding process I will be very interested in those results.



      • Romi on April 19, 2020 at 11:28 am

        Salve admin … novità su hairclone ? Grazie



  33. Stephan on April 19, 2020 at 11:41 am

    I am currently trying out a since 2019 in Germany approved hair loss pharmacy drug called Redensyl. EU effectivity studies available on the net. FT i would really apreaciate to hear your opinion about this!



    • Follicle Thought on April 21, 2020 at 10:28 am

      Stephan, I was under the impression that Redensyl uses an ingredient created by L’Oreal originally called “stemoxydine”, but I’m not certain. Stemoxydine showed some reasonable efficacy I think from its users, but probably described in a category of ‘sub-minoxidil.’ All in all it’s likely one of the best natural alternatives to minoxidil. Some merit for the product I’d say.



  34. matt on April 19, 2020 at 2:20 pm

    https://www.histogen.com/news/histogen-announces-investigational-new-drug-application-amendment-for-hst-001/

    Histogen is making an “amendment” to their investigational new drug application that includes ” The submission is intended to expand Histogen’s IND to be a Phase 1b/2a clinical trial to assess the safety, tolerability and efficacy of HSC, as well as determine optimal dosing in male pattern hair loss.”

    Since they are doing dose ranging in this phase 1b/2a study is there a chance this can go straight to phase 3? Can we get information from Histogen on this through your contact? It also looks like they have partnered with Huapont for their HSC product..meaning maybe the trials happening in China/Japan?



    • Follicle Thought on April 19, 2020 at 3:15 pm

      I’m not sure if it can go straight to phase 3 after this matt, but I will try to get an answer on that. It is definitely possible that some sort of trials or HST program could take place in Asia in the near-ish term future.



      • matt on April 19, 2020 at 3:45 pm

        Thanks Admin, I would love to have an answer on that. I find it interesting that they “amended” this and would have dose ranging being tested in phase 1b/2a because usually that is a 2b study?

        If they are trialing in Asia don’t they just need one trial to show that it’s safe and somewhat affective?



        • Romi on April 20, 2020 at 10:29 am

          Ma HAIRCLONE MORTO ANCHE LUI ?



  35. Mosby on April 19, 2020 at 6:25 pm

    Hi Admin,

    I realised you removed INVITROHAIR from the updated pipeline April 2020 thought they still show information in their webpage.

    Don’t you believe this is a trustworthy company in the run for a potential cure?

    Thanks



    • Follicle Thought on April 19, 2020 at 6:46 pm

      Hi Mosby, I don’t know what to make of the company so I decided not to cover them further on FT. That’s all. You can follow them on their web page if you like.



  36. Devit on April 20, 2020 at 10:34 am

    Hello admin, I saw one video and few comments on RU58841. Do you know the side effects if it? It is not FDA approved but available online.



    • Follicle Thought on April 20, 2020 at 10:37 am

      I don’t know the side effects of it actually, I’ve never used it, but perhaps anyone who has used it for long periods of time could chime in..



      • Yoda on April 20, 2020 at 5:27 pm

        Of course Yoda has used RU, I’ve tried just about everything. I was already on dut and added RU (for 3 years) for an extra boost, which it gave me. However, since I’ve added oral minox and was getting good results I wanted to discontinue RU, it’s an unregulated Chinese chemical and I wouldn’t advise it. I also added topical Dut in my minox, so far off RU for about 2 months, haven’t lost any ground. My guess is that RU on it’s own might not be strong enough. I know, I’ve presented a lot of conflicting info…bottom line, proceed with caution and seek out regulated, proven treatments 1st.



  37. Tiar on April 20, 2020 at 12:09 pm

    Novità su hairclone ?



  38. matt on April 20, 2020 at 3:21 pm

    under “news” on Organ Technologies website it looks like Dr. Tsuji has resigned from his role as director..looks like unfortunate news for this program



    • Follicle Thought on April 20, 2020 at 8:34 pm

      matt, we’ve discussed this a bit in the comments, I’m not sure if this article or previous, but you can scroll through. My hypothesis is that the title change of Dr. Tsuji is not a big deal and does not affect their programs very much.



  39. egghead on April 21, 2020 at 12:34 am

    homie i just read your time table to Tsuji launch said 2027… i thought it was 2020-2021?
    don’t break my heart like that where are your getting your figures ? off hunch?



    • Follicle Thought on April 21, 2020 at 9:30 am

      Egg, the table lists “Estimated” market releases. I haven’t been a proponent of the “Tsuji is really coming in 2020” bandwagon. No one at this time knows exactly when the Tsuji treatment is being released and their website does not show a proposed date, therefore I show a date that corresponds to their recent track record of progress and announcements. The updates and info shared from Organ Technologies is quite sparse. Ultimately, if the treatment comes before 2027, then awesome we’re all happy, if not, then we weren’t raising expectations too high.



      • Soul on April 21, 2020 at 11:33 am

        Hello administrator, I am surprised how you have moved TissUse 3 more years in the table. Haircolne I believe by my personal estimation that it will be 2 more years for crown reasons.



        • Tiar on April 21, 2020 at 2:03 pm

          Complimenti come sempre admin … bisogna capire HEWITT se trova un partner .. speriamo presto … per quanto riguarda TSUJI 2025 mi sembra troppo visto che li manca il test sull uomo … però bisogna capire perchesi e dimesso



          • Follicle Thought on April 21, 2020 at 4:15 pm

            Please use translation before posting a question.



        • Follicle Thought on April 21, 2020 at 3:54 pm

          Like I said before, the dates are estimates and subject to change. If it comes in 2022 it will be the best news ever, the estimated date on the graph is just to stay on conservative side.



      • Kay on April 21, 2020 at 2:14 pm

        Hello Admin, I wanted to ask you a question regarding a treatment I’m going through. I am suffering from hair loss since 1 year but it is not of typical male pattern with receding hairline and all. It is a uniform thinning all over my scalp. I’ve consulted various doctors and the latest doctor I’d consulted suggested me to go for 3 sessions of PRP, unfortunately because of CoViD I got only 1 session which was on 22nd Feb. Do you think 1 session will help me get a little bit of results like some mild regrowth or something because my hairfall has reduced more or less ?



        • Follicle Thought on April 21, 2020 at 4:13 pm

          Kay, it’s always possible that 1 session could help you with mild regrowth, but much more likely that repeated sessions would bring a better chance at success. Some patients show visual results from PRP but it’s likely the majority who do not. Most believe it’s worth a try, though.



          • Yoda on April 21, 2020 at 5:28 pm

            Kay, are you male or female? If male, unless your hairloss is not very aggressive, I’d save your money. I know this from experience not just an opinion.



          • Kay on April 21, 2020 at 11:33 pm

            Thank you, admin and Yoda for reaching back. I have heard that PRP when done in early stages shows best results that is why I was suggested and Yoda, yes my hairfall was aggressive and it has reduced a big deal but now I cannot go for remaining sessions due to lockdown. Hope that I see visible improvements.



      • Yoda on April 21, 2020 at 5:25 pm

        Sounds realistic to me Admin, especially the word “if”.



  40. Stephan on April 21, 2020 at 1:44 pm

    Where can i find the updated table.can find only january 2020



  41. Stephan on April 21, 2020 at 1:56 pm

    Found it. I have a question FT. Why do you change the estimated date for treatments so much(tsuji, tissuse, shiseido e.t.c) since there where no real news about them in this couple of months? Is it a conservative guess of yours for the moment?



    • Follicle Thought on April 21, 2020 at 3:57 pm

      You’ve got it Stephan, also, the longer the companies go without making news updates (like you mentioned) it makes sense that the estimated release date will be further out. If news comes this year from the companies, then the estimated dates could actually get closer. The current dates are very practical.



  42. Follicle Thought on April 21, 2020 at 9:38 pm

    By the way guys, I did just receive an email from Dr. Choi, things are still moving forward. Nothing is imminent but I will most likely do a small update article in the future. He tells me a scientific journal article is in the works and may be published later this year. That’s good to hear. He mentions slight delays due to corona, but the overall tone is positive.



  43. Detlef on April 22, 2020 at 2:23 am

    The biggest questions are:
    – Is Dr. Tsuji still working on hair regeneration and doing trials? Or will the project delay until COVID-19 is cured?
    – Is it a mandatory for a company to publish trials in the clinical trial registry or could it be possible that Tsuji is doing trials undercover now?
    – Does Jon Knight, J Hewitt still force to find a cell processing center for doing SHT-Trial? (maybe in thias corona nightmare he hasnt got money to purchase the trials) Or will the project delay until COVID-19 is cured?



    • Kay on April 22, 2020 at 3:28 am

      Detlef
      The website of organtechnologies japan states that “Takashi Tsuji resigns as director and takes the office as adviser” which does not give clear information whether the work is under progress or not. It could mean that they have failed or it could also mean that they succeeded and now Tsuji has just taken off as adviser.



  44. Mark on April 22, 2020 at 3:56 am

    With the current Global C19 situation I think hair loss & being bald is the least of our worries… 🙁

    Instead of sitting on a hair loss forum discussing treatment & cure fantasies – focus on keeping yourself and your families safe and healthy.



    • Detlef on April 22, 2020 at 5:09 am

      Mark, nobody wants to discuss with you whether Covid-19 or Hairloss is a bigger problem. The people which are in this forum care about hairloss a lot so you have to respect that. The discussion is about the impact of corona on hairloss research not about corona itself!

      If you have an other opinion please leave the forum and let us discuss about hair loss research for our own.



      • Follicle Thought on April 22, 2020 at 11:11 am

        Ok guys, let’s call it a draw there. Truth be told, I am not too concerned about the coronavirus, this is just my personal opinion. The world is already moving back towards normality (in my opinion) and I believe that soon enough all of the usual activities, interests, and concerns will move back to the forefront. Once again, like I said this is my personal opinion and I’m not interested in bantering about corona.



        • Cruze on April 23, 2020 at 10:39 am

          Admin, when would TH07, if gone according to the estimated plan will be available worldwide ?
          Could you please answer ?



          • Follicle Thought on April 23, 2020 at 1:24 pm

            If the trial starts in Q3 2021, then it could reach the market in USA and Canada in Q2 2023.

            If the trial could start in, for example, Q4 2020, then it could reach USA and Canada in Q2 2022



  45. Cruze on April 23, 2020 at 1:34 pm

    Admin
    My question was about “world” not USA and Canada. Will it be sold worldwide as well ?



    • Follicle Thought on April 23, 2020 at 2:57 pm

      Europe and Asian countries may have different regulations about bringing an approved drug into their territories. I’m not exactly sure how long it took finasteride to get into India and Europe, etc. Perhaps an additional 2-3 years to get into other countries? The 3 drugs involved are theoretically available via a compounding pharmacy in most of the world right now, however, it can be expensive get all 3 mixed together. TH07 also has been developed to have the optimal % of each drug as well which is another advantage of it.



  46. GreenMonkey on May 2, 2020 at 4:39 am

    Hi Admin, what I don’t understand is, why are they working on TH07 at all? In the tables in the article, it says that TH16 basically shows identical results to TH07 (50% regrows vs 52% regrows), but if I understand correctly, TH16 will be available 2 years sooner, and have less potential negative side effects, correct? So why don’t they just scrap TH07 and focus on TH16? Why would anyone ever want to use TH07 over TH16 if they are same good?



    • Follicle Thought on May 2, 2020 at 2:30 pm

      You bring up a good point GreenMonkey, however, that data is likely a bit relative. There is no specification for “dense” regrowth in the charts by % or # of hairs. In other words, some examples of dense regrowth and the amount of dense regrowth attained likely varies a lot between the TH07 and TH16 results.

      There’s virtually no way TH16 can really hang with TH07 in results. TH07 contains finasteride and so far there hasn’t been a natural product that can achieve its efficacy. Also, the pictures in the article tell a similar story.



      • Sonic on December 16, 2020 at 9:37 pm

        Great article admin!

        I really find so much of information in the comments section throughout all the articles on website, via good questions being asked and good answers.

        Speaking of, I’ve had a lot of free time the past few days and I’ve gone through quite a lot of articles on your website and I’ve read every single comment (from the several articles I’ve read) and an important conclusion I’ve noted is that there are far more than the 4-6% of users of Finasteride that experience side effects.

        Infact, I believe that figure it the BIGGEST Lie of all time in the hair loss industry. Because for too long people who have been experiencing side effects of Finasteride have been labeled as the outliers or the rare extremely small minority percentage that experiences side effects.

        Upon thorough reading of not just your website comments sections but about 4 other of the biggest hair loss forums on the internet as well, I have come to the conclusion that AT LEAST 60% of the users of Finasteride have experienced sexual side effects (and this is being extremely modest). More realistically its a strong 70% to 80% of users of Finasteride that has consistently reported sexual side effects of Finasteride.

        Infact in all of these 5 hairloss forums (FT included with the other 4 forums) , there’s really only less than a handful of users who haven’t experienced sexual side effects. I refer to these people like Yoda as genetically gifted and these people are always very adamant that side effects are over exaggerated, but if you haven’t experienced negative sides for yourself, you’d always think people are lying. But then again, Yoda isn’t human even in the movie ? But seriously though, people like Yoda and the other 3 or 4 people on this forum who haven’t experienced sexual side effects on Finasteride are just the rare fortunate minority %. I don’t think most people should be even be comparing themselves with such gifted individuals. I mean Yoda hasn’t had sides on Finasteride for decades and he moved onto Dutasteride which is even more potent and has more side effects. He even went onto trying RU58841 which also has many side effects and isn’t even FDA approved amongst many other treatments. Kudos to him, I’m really happy for him and the small % of others being successful.

        But to the majority of users like myself, once having had side effects on Finasteride, I wouldn’t dare touch anything similar let alone stronger, like DUT or RU58841. Hence I don’t consider myself in the genetically gifted range of Yoda. And I think many others should note that everyone is different and we all can’t be respond like Yoda but that is actually very normal.

        Infact it’s the majority of people that get side effects from Finasteride. So this status quo needs to change and a paradigm shift needs to be made.

        Personally, I am very glad that atleast something will be available in 2021 (TH16) and a natural alternative. The results of TH07 look really good, but I wouldn’t dare try it, like many others here have already mentioned, due to it containing Finasteride.



  47. Hope on May 11, 2020 at 10:01 pm

    Hello,
    Does this product contain minoxidil as one of its active ingredients?



    • Follicle Thought on May 12, 2020 at 8:30 am

      There are 2 products shown in this article but the major one does contain (yes) minoxidil, latanoprost, and finasteride.



  48. Hope on May 12, 2020 at 7:56 pm

    Thanks for confirming. Really looking forward to the day something viable, with minimal side effects is released without minoxidil. I cannot use this product
    unfortunately. Keeping my fingers crossed we have something before 2025. Are the products on the pipeline on track as far as you know? I guess the earliest we will see something is 2022 maybe?



    • Follicle Thought on May 13, 2020 at 12:10 pm

      There’s possibly a few delays due to corona, but mostly on track I’d say. I think Samumed and Follica are the earliest new options we’d see.



  49. Michael Lazzari on May 28, 2020 at 10:08 am

    Dumb question, possibly already answered…. Why is it called “Triple Hair”?



    • Follicle Thought on May 28, 2020 at 11:13 am

      Hey Michael, it’s called Triple Hair because of the three ingredients combined to create a synergistic formula to grow as much hair as possible.



  50. davelee30 on March 25, 2021 at 9:32 am

    I see on there web site that Attila Hajdu is bald can anyone find out if he has tried the product as if he has it is not very promising



    • Baldie on April 24, 2021 at 5:42 am

      Maybe he likes th e bald look…..
      saves $$$’s on shampoo 🙂



  51. Peterson on April 24, 2021 at 3:20 am

    Admin, could you ask Triple-Hair if the natural compounds in TH16 are anti-androgenic or not?

    Thanks



    • Follicle Thought on April 24, 2021 at 7:10 am

      Peterson, I am almost certain the main ingredients in TH-16 are melatonin and resveratrol. Not anti-androgenic by nature but may have a protective effect on the hair follicle.



  52. Stephan on May 1, 2021 at 10:07 am

    Hi FT, how do you know these are the two ingredients? Will you make a post when th16 will be availablr online?



    • Follicle Thought on May 2, 2021 at 5:58 pm

      There is a patent online from the founder of Triple Hair using resveratrol and melatonin for hair growth. I will make a post when I talk to them again within the next few weeks, yes.



  53. Stephan on May 5, 2021 at 2:54 pm

    Could you share a link of the patent?



  54. daveblue on May 21, 2021 at 8:43 am

    If TH16 Natural is as good as the other drug related product why do you need them and also there is a TH18 in the pipeline as well.
    I also looked at one of the staff of this company who is shiny bald now if these products worked surely he would have been offered to trial it which makes me very sceptical although the natural i would try it as i am fed up with the amount of chems i have tried over the years on my scalp.



  55. Ralph Wiggum on July 31, 2021 at 10:26 am

    It’s finally available for sale under the name Rizn.

    https://rizn.ca/

    How optimistic should we be about their claims for this product?



    • Follicle Thought on August 1, 2021 at 5:50 pm

      Good news, let’s see how it does out on the market. I don’t think they’ve gone over the top on their claims, but have set a slightly lofty expectation. I’m planning to have a separate page for Rizn reviews on this site.



      • Colin Campbell on August 30, 2021 at 3:15 pm

        Admin, where can the results be found and posted? I ordered a few days ago.



        • Follicle Thought on August 30, 2021 at 6:20 pm

          Will share the link asap.



          • DAVID LEE on August 31, 2021 at 4:25 am

            Hi i notice Triple hair will not ship to uk which is annoying.



            • Follicle Thought on September 2, 2021 at 8:54 pm

              Sorry to hear that David, I imagine that issue will be resolved as they expand their distribution network.



    • Bob on August 1, 2021 at 8:02 pm

      Clinical Trial “29 participants” for 6 months……

      Tell us another……



  56. Remy on September 8, 2021 at 6:12 am

    Just ordered 4 months supply. I’m in early diffuse thinning stage, will update after 2, 3 & 4 months.



  57. jose on February 12, 2022 at 5:49 pm

    some updates?



    • Follicle Thought on February 12, 2022 at 10:06 pm

      I have talked to Jean at Triple Hair and there will be some Triple Hair updates by Summer. Should be worthwile.



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