Shiseido Releases RCH-01 Trial Results 2020
Replicel Terminates License With Shiseido: Update (12/21/21)
Two months after Replicel announced that it was entering arbitration proceedings with Shiseido, the company has announced today that it has terminated its license agreement with Shiseido. The license agreement between Replicel and Shiseido dates back to 2013 when Shiseido paid an upfront fee to gain the rights to commercialize Replicel’s cellular hair growth therapy RCH-01 in Japan. Since then, Replicel was unable to complete its own trial of RCH-01, which was part of the agreement and this caused Shiseido to withhold the data from their trial of RCH-01. It appears that this announcement is a legal action step which Replicel would need to take in order to ever prevent Shiseido from commercializing RCH-01 in Japan. This creates an awkward situation as Shiseido is currently trialing RCH-01 in Japan with hopes to market the treatment if it proves successful.
As the arbitration will continue, this will not be the last we hear of the Replicel/Shiseido situation.
Shiseido Plans To Pursue RCH-01: Update 3/12/20
Directly from Shiseido’s “New Research” webpage regarding the RCH-01 therapy:
“Safety level and improvement effects were confirmed in a clinical study conducted by Tokyo Medical University from 2016 to 2019 using our autologous cell culture processing technology. A further clinical study aiming at practical application will be conducted in the future.”
Also, earlier this week a joint press release from Tokyo Medical University, Toho University, and Shiseido Co. was shared with me. This press release was issued on March 6, 2020 and contains details about the RCH-01 trial results which were also published online last week. Tokyo Medical University and Toho University are the two institutions which carried out the RCH-01 trials in conjunction with Shiseido. The press release contains some interesting quotes which are likely unexpected by most of the audience. Let’s take a look at what was said:
“In this clinical study, we confirmed the safety and effectiveness of cell therapy technology and we aim to develop cell therapy for a wide range of people suffering from sickness and thinning hair.”
[Future research development and ripple effects]
“In this clinical study, S-DSCTM was injected only once into a small area of the thinning hair to increase the effective cell concentration. Decided and confirmed safety. However, in order to actually use it in clinical practice,It must be administered multiple times throughout the thinning hair area to show a visible therapeutic effect and safety. We will conduct clinical research for this purpose in the future.”
Shiseido and their co-institutions clearly state that they aim to develop the cell therapy to offer it to patients in the future and they will conduct clinical trials using RCH-01 (S-DSCTM) in the future. I think many people would have guessed that Shiseido was done with dermal sheath cup therapies after the modest results from their trial, however, that may not be the case according to this press release. It’s quite a turn of events, what do the readers think about this latest statement from Shiseido? Comment below. (HLC Japan also covered this)
Shiseido/TokyoMedical/Toho University Press Release in English
Original Article
After a prolonged waiting period, Shiseido has finally published results from their highly anticipated trial of Replicel’s RCH-01 technology in Japan.
One thing is for sure, anything is possible in 2020 if we’ve finally received Shiseido’s trial results. Earlier today, I was guided to a study published in the Journal of the American Academy of Dermatology by a commenter on Follicle Thought. The article, which indeed contains RCH-01 results, is titled “Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose Finding Clinical Study.” A synopsis of the study is given on the article’s listing page. Below, I’ve shared the important bullet points from the synopsis:
- Methods: Dermal Sheath Cup cells dissected from occipital hair follicles were cultured to manufacture (more) DSC cells. Subjects with male or female pattern hair loss received single injections of 7.5×106, 1.5×106 or 3.0×105 DSC cells or a placebo in 4 randomized separate regions on their scalp, and hair densities and diameters were measured up until 12 months later.
- Results: Fifty males and 15 females aged 33 to 64 were injected with DSC cells. Total hair density and cumulative hair diameter at the 3.0×105 DSC cells injection site was significantly increased compared with the placebo after 6 and 9 months. Men and women showed similar improvements and there were no serious adverse events.
- Limitations: Positive results were only seen up to 9 months post treatment.
More elaborate data from the trial is detailed in a 25 page PDF which has been published online by the AAD. This complete version was actually shared online thanks to forum member ‘Left4Bald’. Below, I will take a closer look at some important figures from the expanded trial data.
Analysis Of RCH-01 Trial Data
www.sciencedirect.com/science/article/abs/pii/S0190962220302723
The two graphs above display the mean or average results from the trial, you are able to click on the image to enlarge. The following is a summation of the trial outcome:
- Depicted in chart ‘a’, the average increase in hair density peaked around 5 hairs /cm2 at 9 months post-treatment and subsequently diminished.
- Interestingly, it was the dose with the lowest concentration of cells (the 3.0×105 dose) which gave the best results among trial participants. Another unexpected revelation shown in the data is that older subjects (subjects 51 and older) responded best in the treatment groups.
- Not very surprisingly, trial subjects with lower degrees of baldness, Norwood 3 & 4 and ‘Shiseido Female Grade’ 3 & 4, responded better to treatment.
Phototrichogram Images
Above is one of the two phototrichograms shared in the study. This 43 year old female subject displays an observable increase in hair density at the 9 month mark. The other trichogram found in the PDF shows a 53 year old male, without much noticeable contrast between baseline and 9 months.
The researchers noted at the end of their document that this trial included a single injection at each of the 4 observed scalp sites per participant, but, preclinical data has shown that repeat injections can improve effectiveness. The study publication was concluded with this sentiment:
“this clinical study of autologous cell therapy using DSC cells to treat male and female PHL has shown positive, although temporary, responses at the lowest cell concentration injected, and further studies are warranted…..In order to determine if this cell-based treatment provides a significant clinical change noticeable to patients and practicing physicians, additional clinical studies injecting DSC cells in larger hair shedding areas should be performed to demonstrate a visible effect by global photo-assessment.”
As of now, it appears that a further differentiated clinical trial involving this DSC cell therapy would be necessary if we were to see it move forward. It also remains unclear if either of the two companies, Shiseido or Replicel, will decide to pursue this further.
Please share your reactions to this news in the comments below.
Thanks to Mattt for sharing the link to the cell therapy study.
At last we have the results! A lot of people will be disappointed but I think for hard-core researchers of proposed hair restoration treatments, not surprising. I would be amazed if further trials were conducted as the results have not significantly improved on Replicel’s initial trial. However, I don’t think this is the end for Shiseido in hair restoration as they were also said to be developing their own treatment along side this. Who knows but in a way I’m glad this one has been put to bed based on the hopes a lot of people on this forum had for this treatment. Cheers
Thanks for the feedback Welsh, good to hear from you by the way. I think your assessment makes a lot of sense.
You are indeed correct that Shiseido does have alternate research lines going for hair, though, details about those projects are generally kept internal since the company is a publicly traded global player.
ah after so long and so much hope in this one i feel deflated i was putting most of my faith in replicel as it all sounded so good coming up to my 60th birthday soon time is getting shorter will anything really provide any decent results was hoping id get a confidence booster in my latter years but i have to keep hoping
” i know have you feel ,i am 62 now and i can understand how you feel.
I really don’t understand these results. It’s like they say it works really well and also it doesn’t?
What part do you see them saying it works really well?
@Dante there is significant increase in hair diameter and density for up to 9 months
Why can’t they just do injections every 6 months?
D1, when they say significant increase in the study it means “statistically significant” which can actually be a somewhat low number.
Injections every 6 months would be interesting to see but unfortunately it would be a costly trial. Companies like HairClone can plan for this in their upcoming case studies with patients in the UK.
??So when will this come out??
According to industry standards, it does not seem overly likely that the treatment will be released based on these results unfortunately. Of course, Replicel could continue to pursue the therapy themselves.
You can count on Replicel addressing the situation in a company newsletter soon though, so they can at least set the record straight.
The cells lost inductivity in culture. That is the problem. Same as with Aderans and Intercytex.
Would this’ll work better than some people is claiming about exosomes?
It’s very difficult to answer that question because there have most likely been little or no exosome treatments which have been clinically evaluated through a precise method like trichograms or similar. Most likely the two treatments would be in a similar range.
I think this treatment would be VERY beneficial to patients. It keeps hair that isn’t lost healthy. So let’s say you get Tsuji’s treatment and it costs $50,000. You don’t want to get the Tsuji treatment again in 4 ot 5 years so you get the Replicel treatment every 9 months to keep your newly acquired hair healthy.
hope you have a fat wallet ha ha
It would be very interesting to have the comments of Dr. Paul Kemp on the results.
Well… Doesn’ t an increase mean it stops HL in fact? And even new hair grow? So much better than minox works to me by just slowing it. So i think if an every six months treatment would have the same effect every new period , this could really be the treatment. Please correct me if i am wrong…
How is this different from HAIRCLONE? It’s very similar if I’m not mistaken. I hope I’m wrong and not disappointed like this
HairClone uses dermal papilla cells, Shiseido was using dermal sheath cup cells. The cells are taken from different areas of the hair follicle.
Shiseido’s problem is that they didn’t protect inductiviy during culture. It’s the same problem that Aderans and Intercytex had.
Hairclone is trying new techniques to protect inductivity during culture.
Russell have you reviewed the Stemore article? Think you might really enjoy that company, I do.
As Yoda has said before, don’t put all your hopes into a cell based/cloning solution to become available in the next year or two. Odds are you won’t be popping over to Japan, dropping a few grand and coming back with a full head of hair. While anything is possible it doesn’t mean it’s probable. Root for the treatments that are actually in Phase III as I write this, Follica and Samumed. No guarantees they will come out but the probability is much higher that we will see something from these guys in the next couple years.
is not to put our hopes in cloning etc, the same can happen with follica and feel just as disappointed. be cautious, as for example with “Hairclone” it may end up just like replicel.
It’s sad how you see falling into possible treatments that could have helped…
Cell based not call, odds not odd, …man I wish you had an edit feature Joe! 😉
I’ll make the edits for ya this time Yoda Yodes. 🙂
Thanks admin, you’re the best. Another thing Yoda has said often! 🙂
This does kind of narrow down the options for a target therapy thought so that’s a good thing we know sheath cups dont work.
I’m not shocked at all this treatment didnt work out. If they could legit cure baldness or regrow tons of hair it would have been all crazy media on it. I remember follica was being advertised as the newest cure for hairloss in NBC news. Yes this was 10 years ago but it’s the only company to be on TV. My gut still tells me follica will be the next big breakthrough. Not a cure but 4x better than what’s out as they claim. I agree with yoda since we have been in this game for 20+ years. SM has big time political investors dumping money into it so I’m pretty sure this will come out too so they can cash out. Follica SM 2022. Tsuji will be the cure but probably not for another 10 years. They have a long way to go with trials, testing, safety then if that pans then distribution, licensing, clinic offering, marketing etc. This can’t happen over a span of two years. Like I always say, hop on the big 3 and live a healthy lifestyle to save your hair.
So the first definitive statement we’ve had for years on hair loss…. Is that one of our biggest hopes…. Is dead int the water.
I just… Cant.
Replicel turned out to be an utter disappointment. Lets hope HairClone and Tsuji don’t succumb to the same kismet!
HairClone is no different than Replicel, which is no different than Aderans, ICX, and Gho. Tsuji doesn’t know anything, which is evident by a guy who hasn’t done a single human study and proclaimed he would have a treatment on the market in a year. This is especially dissapointing given he is working in a field where it’s well known it’s easy to grow hair on mice, but numerous researchers have failed to transition the results to humans.
Most astonishing, Shiseido spent the last 3 years duplicating Replicel’s phase I study without doing a single deviation, and now they are ready to perform a phase II to try to tweak it to use in a clinical manner.
It’s odd that their study showed less = more, unless more meant they had to use more cell passages in order to make up the higher amount.
Yep , disappointment as expected. They are just letting us all down gently as they knew the anticipation hair loss sufferers had regarding this “potential” treatment. A real treatment is the day a bald man can have the head of hair of a teenager.
Well not the results we were hoping for.
With regards to whether this is an indicator as to whether Hairclone will fail, it would be great to get Paul Kemp’s thoughts on this.
It would seem that Aderans back in the day achieved superior results, that were longer lasting (?)
I am hoping that Hairclones approach will be better as Replicel/Shisiedo are trying to get DSC cells to ultimately convert into DP cells, whereas Hairclone are going straight for DP cells, this is quote from the paper;
“Regarding the proof of concept of this treatment, a reasonable explanation is that due to the migration of injected DSC cells into pre-existing miniaturized hair follicles and their incorporation into DP and DSC regions, they presumably differentiated into DP cells”
Also by their own measure the inductivity of the cells was not exactly optimum.
They guaged this by using ATP activity which they had measured to range from ‘moderate’ to ‘weak’.
I seriously hope Hairclones treatment will be far better and that Tissuse/Jon Knight can get a SHT trial going this year.
Doesn’t Paul Kemp monitor this site?
Yes he does, I would not be surprised at all if he were to share some thoughts in the comments soon.
@FolliceThought we are going to need some strong results from others now. That secretive cosmetic is looking needed
Definitely needed
I’m sure it will come.
What will come?
https://gramho.com/media/2233114120773142006
Hey, I’ve found new some new exosome results, older guy had great regrowth in 50 days (they didn’t specify how many treatments)
https://gramho.com/media/2233081671372250791
This is another guy, impresive regrowth after 150 days (6 treatments)
I think this is shaping up to be the best non invasive option we have ATM in hairloss world. We didn’t see that much coverage, in some interviews doctors and techincians were impressed and suggested that exosomes significantly outperform every other injectable.
Purity and safety are main concerns (with price), after that dosing, method of application etc..
What are your thoughts guys?
These are interesting results The, as long as the doctors are not intentionally trying to deceive in the 50 day guy results, I’d like to see more follow ups with that guy.
Pretty impressive results. But are they outliers, or is this a typically what can be expected?
Admin can you please check this article?
I expect news about Dr. Tsujis hair regeneration!!
https://premium.toyokeizai.net
Thank you Hans I will look into it.
Hey Admin, it would be very nice if you could read the whole article. I think you are able to finance this paywall article because you get some money with the affiliate links. I click often on the links that you gain provision.
Please check the article there might be informations about Tsuji trial!
Thanks for your support Hans, I really appreciate that you do that to help. It is the links with the blue X marks in the right corner which support the site every time.
Patreon is also the biggest way people can help https://www.patreon.com/FollicleThought I’m trying to get more info on this publication currently.
Thank you for your message. It is a pleasure for me to help you.
But please check the Tsuji article ok?
Hans please include your email when you fill out comment form so I can reach you.
Hello Admin, I think the informations of this Tsuji article are interesting for everyone not only for me. Thats why i ask you to publish the INfo on your blog and not only send me per E-Mail. Thank you!
Ok, thanks Hans, will follow up in the future.
HELLo admin, what did you read in the Tsuji article?
Hans, sorry did not see any update in it.
How much are the treatments? I have been quoted by a reputable Dr. in the field 6K per. I’m sure with 6 treatments there’s a discount but still close to 30K. No thanks, those results don’t rock Yoda’s world! Exsomes will be this decade’s PRP, just my opinion.
@yoda I don’t know how much they charge. My argument has been founded solely on efficacy. Exosomes are el dorado for scammers, dark market, where you often don’t know purity, source of exosmes, etc.
Having said that, price is not product of demand but of source, extraction process and underdeveloped economy of scale. That is why they quoted you 6K.
Back to efficacy, there are no detail studies exploring dosage, frequency, method of application, and possible different source of exosomes. For instance XoFlo derives exosomes from mesenchymal stem cells from umbilical cord, and they are cheaper ways to derive these cells (DP cells for instance), but we don’t know how potent they are, or their efficacy as hair regenerative treatment.
I think results, if true, are quite impressive to be honest. If price goes down by a factor of 2 or 3, with little bit of research I can find the right clinic, then I’m definetly doing this.
Have you had exosome treatment previously The?
No
@The, my comments weren’t solely focused on cost…it’s the results vs. the cost. If this showed the guy regaining a full head of hair then it would lend itself to the average cost that is being quoted for Exsomes. While I agree with you that there are no standards I don’t agree that the results in the link you provided are anything to get overly excited about. Sure, if it cost a few hundred bucks a pop then why not give it a whirl. Unfortunately, the results to me aren’t much better than what we’ve typically seen with PRP. I have direct experience with one of the top docs in the country with PRP and the only thing it helped was to lighten my wallet.
All I see is no cure for baldness. This therapy is crap.
Hi Admin,
any update on the applied biology shampoo that will help non-responders to minoxidil?
Steven, thanks for asking I will follow up on that this week.
Time to sell Replicel
Question for admin and all you hairloss experts:
I’m 39. Diffuse thinning on top. Over the last few years, I’ve also noticed that I have less hair on my legs than I used to. Less chest hair. My stubble isn’t as dense as it once was.
Now, is this a case of “You are getting old, your hair is just going away gradually” or could this be something that needs addressed? I still have leg hair and chest hair, and I can still grow a beard, but all these areas are nearly as hairy as they used to be.
A few years ago, I got my thyroid checked by my GP, but I think it was a basic check. Anything else worth checking?
One thing I’d say is leg hair can decrease due to friction from jeans or pants. I’ve experienced it before. Chest hair on the other hand tends to stay pretty solid and even increase over the years when experiencing scalp hair loss. All in all, potentially best to speak to a derm who sees these patterns a lot.
39! You’re not old Bro, Yoda has almost 20 years on ya Sonny! 🙂 Are you on fin or dut? That can limit your body hair growth, not harmful though. If not, you might want to check in with your GP or a Derm.
I said “getting” old, Yoda! I’m like Luke at the end of Return Of The Jedi, only I’m losing hair and body hair instead of hands.
Not on fin or dut. Gonna ask my GP. I believe The Maitland Clinic (London) has a special tricologist, so might see what she says. I’m probably grasping at straws, but you never know!
Boy, I don’t know Pauly…I know things are different in the UK but I cringe when I see the word “tricologist”. Yoda doesn’t know what he’s talking about but it’s never stopped me before, wondering if it could be an inflammatory condition like alopecia areata? I’d see an actual doc, but do what you feel comfortable with. Good luck to you!
Update (3/9/20) New press release from Shiseido says they may in fact be pursuing this treatment further. Go back to top of article for the link and full update.
I think this treatment could be useful. If you recovered your hair from Tsuji you might need expensive re-treatment with Tsuji but this Shiseido treatment looks like it could be a less expensive way to keep your old hair and new hair healthy by getting Shiseido injections every 9 months if your Tsuji treatment started looking like it was wearing off and you might be starting to lose hair again. You would still have a full head of hair thanks to Tsuji’s treatment but the individual hair shafts might look like they’re starting to thin so you would quick get the Shiseido injections and that would revitalize your hairs less expensively than it would cost to get another Tsuji treatment.
The biggest question in my mind is, does the hair eventually thin and fall out because the dermal component of the remodeled follicle is still affected by DHT? Or is it due to a general fading-over-time of the stimulated micro-environment the injected embryonic cells provided.
I’m thinking Shisheido (ongoing) + Follica (ongoing) + Breezula (ongoing) would be a powerful synergistic weapon.
@FollicleThought this looks good… https://clinicaltrials.gov/ct2/show/NCT04293822… could commerialise quickly as well i guess. what do you think?
Yes, it could become an adjunct or alternative to minoxidil. It’s great that the study is testing it against minoxidil. We’ll see results around year’s end I’d say!
Does anyone have experience with the following product?
https://minoxidilexpress.com/product/fr-12-12-minoxidil/
Yes Nobody, I’ve tried this and some of the other products. Can’t really say that sulfate is anymore effective than standard minox or is just a gimmick. This might be related to my specific situation. However, I do think they use quality ingredients and manufacture to high standards.
Thank you Yoda for the quick answer?
Hello yoda! Have you tested any other minoxidilexpress products that you could recommend? I spoke to a dermatologist and he recommended that I test the products over 6 months to see success. I am currently testing the FR-10 product. Thanks in advance
It depends on your particular situation like age, how long you’ve been thinning, response to minox in general, on fin or dut, etc. FR10 is a good choice, I’m on it once a day, something else at night. But what I use is not indicative to what you should use, I’m also on oral Dut and Minox, have been thinning for 40 years, on topical minox for 35 and am as old as f*ck! 🙂
Thanks yoda for your opinion! My hair loss only started at the age of 40. I am now 48 years old and have been taking topical minox 5% for 10 years. Hair was getting thinner, but I never wanted to take oral finasteride. So what do you think of topical dutasteride?
WTF…RCH-01 failed abysmally during trials. Yet, the powers that be want to commercialise it? Given that it is completely feckless, who in his/her right mind is going to spend money on RCH-01? Someone please help me on this one because it defies logic!
Oral is always better than topical but I’d hop on topical fin or dut if you won’t go that route, either in the minox itself or as a standalone treatment. Standalone has a higher concentration but it requires an additional thing you need to dump on your head. Maybe start with it mixed in the minox and if you need more juice go with the standalone.
I am really confused. Wasnt it ment to do multiple injections during this trial?but now they say they made only one injection… Whats new compared to the trial in 2016? only the diffetent dosage? Please correct me folliclethought if i am getting something wrong
And now a word from Yoda the broken record…don’t put all your hopes into a cell based/cloning solution to become available in the next year or two.
I believe people get disappointed because they hear dates like 2020 thrown around and they have set expectations that this is a hard stop. These are targets, we aren’t on the inside so we don’t know exactly what the targets mean. I can’t remember ever reading DIRECTLY from Shiseido or the coveted Tsuji that they were coming to market in Japan with a commercially proven, readily available, relatively affordable treatment for sure, definitely in 2020 for sure…but that’s what people read into it. This is good news, they continue to refine a potential ground breaking treatment that MAY become available sometime in the near or not so near future. Better than pulling the plug.
@Follicle Thought the update doesn’t really explain how they are going to try to fix the faults they have has this time. Nor does it explain how they expect to get something commercially viable from this
D1, I’m not saying that their plan/theory is a guaranteed success but Shiseido does make it clear that they are looking at multiple consecutive injections to improve the efficacy of the treatment in future practice.
They’re still testing and and optimizing Bro, what the f*ck do you want? Admin, can you please tell me the future? What age will I die? Pick some stocks for me that are definite winners ? Geeez!!
Yoda, definitely invest in Tesla and uhh can’t remember the name of that company that had a baldness cure in their pipeline, whoever it was, invest in them, they will make millions 😉
The All-knowing Admin! 😉
Tesla’s down 50%. Amazon, Walmart, and Costco the only retailers who can survive. Short everybody else.
Well if you’d bought enough Replicel stock at 0.15 CAD Monday and sold it at 0.31 today you’d be pretty happy!
Article has been further updated to show a webpage on Shiseido’s site which mentions plans to conduct a new RCH-01 study.
PRP result and shiseido result are almost equal. Both results are TEMPORARY….
They gave just one injection n took 3 years in phase 1 study.
Take a look at the image https://i2.wp.com/www.folliclethought.com/wp-content/uploads/2020/03/Shiseido_Trial_RCH01_Results.png?resize=768%2C267&ssl=1
As you can see you need injections every 9 month to stop decreasing hair’s numbers.
And if we look at female scalp photo after 9 month https://i1.wp.com/www.folliclethought.com/wp-content/uploads/2020/03/Shiseido_trichogram_RCH01.png?w=529&ssl=1
There is no so significant effect. They really lost so much time. They should doing multiple injections trials at the same time.
Fuck it. The whole Industry is full of clowns. Time for a hair system until Stemson arrives (first legit company since Merck imo)
Interesting development.
Not necessarily good or bad news, could have a silver lining here.
Wow, big dislike for replicel. Instead of bringing rch to market the sue shiseido for their progress. Shame replicel, good luch shiseido!
What does this mean for RCH-01 Follicle Thought?
Does it mean that Shiseido is out of the picture now?
It means they are going to continue arbitration to see if they can come to an agreement on commercialization rights (aka the license). If they can, then Shiseido will evaluate their current trial of RCH-01 and potentially market the treatment. If they can’t Replicel may have to pursue further legal actions to prevent Shiseido from marketing the product (if it is worthy of being marketed).
Can someone direct me to a summary of exactly what the issue is between Shiseido and Replicel? What are they butting heads about? Is there any evidence that this stuff actually works? If not, why are they even bothering?
money
I am not 100% certain on details, but I’ve given summaries on the Updates page previously, I believe. Even the recent one has some info. Basically, Replicel agreed to also complete a trial of RCH-01 and share data with Shiseido after they signed the agreement in 2013. After that, Replicel didn’t raise much money and they claimed that they were not capable of launching another trial (while paying salaries of the people who work for them). Shiseido then got ticked off about that (potentially due to the fact that results were not spectacular as well) and said “okay well, you broke your agreement with us and now we don’t have to keep up our end of the bargain.” And here we are.
Thanks. Since the results weren’t particularly good, why are they bothering with licensing the product at all?
The license happened in 2013.
At this point, I have completely lost faith in replincel or shishito to bring anything into fruition . I doubt these injections are anything but useful for people with AGA and would have most likely been marketed in the general cosmetic realm for people looking to rejuvenate their already thick heads if hair
And better.
Because it is easier to transplant a human heart to a person who has diabetes than the technology of getting hair with the method that Replicell has.
Eight years no progress plenty of disagreement it’s good time to move on I think Histogen had exactly same script before they fold
you have to go to Hollywood
If you want your hair back https://www.instagram.com/p/CXvfPHFq5ty/
Admin,
What do you think is going on with hopemedicine and their AGA phase 2 initiation?
I’m starting to get scared
Things take time, I don’t know what’s going on, but it’s not alarming to me yet especially with volatile health regulations. I expect them to start the trial by H2 2022.
What a bad news,every hopeness were killed
To me, the replicel patent thing sounds fraud. I had believed in their updates and waited for several years but nothing came out. Why does replicel block shiseido to use their useless & worthless patent?
FT you wrote last year about moongene medi and you said “ Moogene has a developed a microbubble-nanoliposomal delivery system to get gene editing particles directly into the dermal papilla cells of the hair follicle. First, a sequence of sgRNA or “guide RNA” is created to target the SRD5A2 gene; this is the gene responsible for creating the 5AR enzyme which converts testosterone into DHT, the known core driver of androgenic alopecia. The combination of Cas9/sgRNA, which is designed to suppress the SRD5A2 gene, is then encapsulated into nanoliposomes which are attached to microbubbles (see image below for depiction) within a topical solution. The topical solution is then applied to skin containing hair follicles (it has so far been tested on mice, and next will be tested on non-human primates). Then, ultrasound of a specific frequency is applied to the skin which bursts the microbubbles and creates momentary cavities in the surface of the skin to transport the nanoliposomes through the epidermis and into the dermal papilla bulb/cells. The Cas9 protein acts as the scissors to cut into the native RNA and allows the crafted sgRNA sequence to suppress the 5AR gene within the dermal papilla. The hair follicle cells, thus, are modified to be theoretically genetically exempt from DHT interference”. Does that mean that this a one and done cure or is this another long term treatment that have keep going in to the doctors office to get? I don’t want to hype myself up
Woofy, thanks. I mentioned in the article that E. Hui of Moogene didn’t want to comment on how many treatments would be needed for maintenance, but his guess was that it would be very reasonable. Certainly not something you’d need every few months.
any new about Follica, Triple hair or CB ??
Cheers and Happy Xmas guys!
This was the predictable outcome so not even disappointed. Anyways, Happy Xmas and New years – in Advance to the FT community. Hopefully the new year brings about some hair-related progress.
Merry Christmas everyone
Well not sure about that information…
But what is Paul Kemp up to? Will there be another interview with hairclone next?
Apart from that merry Christmas to the community!! I feel like without this site I wouldn’t have made it this year… Thank you.
Thanks Hopefulhead, I think more than likely we’ll have a HairClone update in early 2022.
@ chrome dome, there are two companies l am looking forward to 1,Hair clone was ready to run trial from 2020 hope they do it early 2022.This trial means they can widely offer treatment if it’s successful 2,Mane biotech nobody seems to be excited as I am they are the only company use cure in their wording hope something comes out 2022 or definitely 2023
Merry Christmas and wonderful New Year
Kapil, I would not recommend basing your opinion of companies on what words they use to describe their treatments. I think Mane is very interesting as well, but we’ve got to see what they have to offer. I’m looking forward to them sharing something in 2022.
So is kintor sharing the phase 2 trials this year or are they delayed?
At this point I would not be surprised if they were released in January.
I have seen a tratament called QR 678. look intetesant
Looks like Kintor is going to be delayed unfortunately with the Phase 2 results. As much as I want to see it, it doesn’t matter right now as long as they start their Phase 3 trial on time in early 2022, because the Phase 2 results will have to be released at some point before phase 3 results are released.
The main thing for now is that they finish the clinical trial process quickly and correctly, we can always have time to view their trial results before they release to market.
@Admin what happened to the trial results of Applied Biology’ SULTA1A1?
Would be a good addition if it does truly improve Minoxidil effectiveness.
The trials were published in a journal, you’d have to dig in the article comments to find them. From what I remember, not overwhelming. Dr. Goren told me a 3rd party company would be marketing the product, still haven’t heard any updates.
Kintor Pharma Provides Update on One of its Three Multi-Regional Phase 3 Trials of Proxalutamide for COVID-19
Kintor Covid-19 results doesn’t match what we heard
What we heard was too good or above all expectations
Hi Follicle Thought,
What is your opinion on SMP (Scalp Micropigmentation), does it look natural in real life?
I came across a lot of these companies that offer the treatment on instagram and youtube, some results look more natural than others, but I have yet to see someone with this treatment in real life.
Do you consider writing an article about this procedure?
It seems to be not a very well known treatment, when I searched for information I see that most people on reddit who answer the questions are practicioners themselves so they might be biased in the answers.
I think the procedure has been around for a while but I don’t think we have yet came to a point where it looks natural in all different lighting.
SMP is a great resource, but it depends on the artist. Just like hair transplants, some have great skill, some only possess enough skill to complete the procedure. If considering SMP, spend several weeks doing your diligence and engage with people who share reviews.
Thanks Follicle Thought,
Have you seen any SMP results in person, if yes does it really look like the person has a full head of hair but decided to shave it off, or it comes off as a tattoo?
I have seen one result in person, it did not look bad, but I also knew the person had SMP, so I was expecting it. I think artists that create a softer hairline can create SMP that looks realistic. Also, adding some FUE grafts helps create a 3D effect.
Should have new article out by Sunday. Something new to chew on for a little while.
Hi admin, when is your contact going to get surgery using veterporfin?
Maybe by Q3 2022 Flyingfish.
I wish everyone a happy new year and that 2022 brings us some good news:-)
HAPPY NEW YEAR
Same to you nobody, thanks and Happy New Year to All!
Man this is an extremely safe bet. It is clear already today that there will be no new treatment, as it would need to be in phase 3 clinical trials already today. I think the best we can hope for is that Kintor is starting ph3 clinical trials, hopemed starts a phase 2 and (most importantly) Stemson makes good progress, fine-tuning their protocol. I really do think that Stemson might solve it all and I never had this feeling with any other company before. While they obviously won’t cure it anytime soon, every good news from Stemson keeps our hopes alive!
I don’t think anyone in the last 6 months was expecting hair loss to be cured by the end of 2022. That said, there are potentials coming in 2022. For example, HairClone to begin offering DP cell therapies to close practitioners in the UK. One or two Korean companies beginning DP cell trials. Kintor Pharma moving into phase 3 and also giving us data from pyrilutamide and their advanced drug GT20029. I mean, to be honest 2022 is slated as a much better year than 2021 was slated for, mostly because of Kintor.
And so, chrome dome I understand the anguish you are feeling waiting for hair treatment news but I want to let you know that FT is not the place for the doom gloom comments. Putting that kind of mindset out there is not helpful to you or anyone else; no one is overpromising and setting you up for a big disappointment.
we will have the new product of rizn this year? or some product new for prp?
Happy new year to all! Hairclone can a hit or miss. And if by any chance DP cells therapy shows results, then it would be game changing since many companies are involved . But there is always a chance that it might fail, but i guess my fellow FT mates visit this website for the game changing part and not for “cure is always 5 years away” part .