SULT1A1 Minoxidil Response Booster Product: First Look
SULT1A1 + Minoxidil Human Study Published (Update 6/18/21)
As foretold by Dr. Andy Goren below, Applied Biology has published a peer-reviewed study comparing the effect of the SULT1A1 booster in conjunction with minoxidil to minoxidil alone. The study titled “SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth” was published online in the Journal of Cosmetic Dermatology on June 16th.
The results of the 24 man study state that the group using SULT1A1 before applying minoxidil had a higher hair regrowth response rate, 9 out of 12 subjects, compared to the group using placebo before applying minoxidil, only 4 out of 12 subjects. One factor worth noting is that the hair regrowth was observed using global photography (regular headshots) instead of macrophotography (highly magnified photography).
Check back for an update within the next several days, I plan to get a copy of the PDF from Dr. Goren soon.
Further Information From Applied Biology (Update 11/4/20)
I have received further responses from Dr. Andy Goren, founder of Applied Biology, regarding the details of the newly announced SULT1A1 product. Below are two important revelations about the product:
- Applied Biology is currently conducting human studies to observe the amount of hair growth resulting from use of the SULT1A1 booster along with minoxidil compared to minoxidil mono-therapy alone. The results are expected either early 2021 or late December 2020, prior to the launch of the SULT1A1 product.
- Regarding the use of the product by both men and women and the use of the product by current responders or non-responders, Dr. Goren shared this insight: “We have seen increased expression of SULT1A1 in both men and women. In theory it would improve minoxidil response even in subjects that have high SULT1A1 expression; however, this still needs to be validated in a clinical study (which is one of our ongoing studies).”
This points to the booster being primarily intended for people who are non-responders to minoxidil, which was expected. However, as you noticed Applied Biology is also doing a human study to test the effect of SULT1A1 on a larger number of subjects who already have high levels of sulfotransferase enzymes in their hair follicles. I believe this covers all of the inquiries that readers had following the initial publication of the article.
Original Article
Today, we take a sneak peak at the new minoxidil response-enhancing product from Applied Biology, SULT1A1.
SULT1A1 – MinoxiBoost Product Sample
I was happy to receive a sample this week of the anticipated product from Applied Biology which increases sulfotransferase enzyme levels in hair follicles to improve minoxidil response. This product has been listed on Applied Biology’s website as AB-103. In the photo of the sample I received, you’ll notice the label says “MinoxiBoost”, though, I’ve been told by Dr. Goren of Applied Biology that when the product launches early next year it will actually come out under the name “SULT1A1.” Big thanks to Dr. Andy Goren at Applied Biology for the product sample.
There is currently a website for MinoxiBoost (SULT1A1) which contains some data on the product including a study using colorimetric dye to document an increase of sulfotransferase enzyme levels in collected hair samples. It appears that Applied Biology has created the product line “MinoxiStyle” to be sold by distributors instead of direct to consumers. I will share the website for purchasing the individual SULT1A1 product in the future. At this time, Follicle Thought has not entered into a product affiliation with Applied Biology.
Finally, I have been given the peer-reviewed study of SULT1A1 to share here from Dr. Goren. In summation, 10 of 19 study participants showed an increase in sulfotransferase hair follicle activity after 14 days of applying the SULT1A1 formula twice per day. The greatest responder showed a 7x increase of sulfotransferase enzyme levels after using the product. The formula seems to show better responses in females. I will follow up with Dr. Goren on the reasoning why some male subjects ended up with lower enzyme levels after using the product.
The directions for the SULT1A1 product are as follows: Apply daily to the base of the hair. Wait at least 10 minutes prior to washout. SULT1A1 requires at least 10 minutes to activate and accelerate the sulfotransferase enzymes in your hair. Do not apply at the same time with Minoxidil, wait until the product has dried to apply Minoxidil.
I’m told the product is planned to launch in January 2021.
Let us know in the comments below if you plan on trying the product.
Posted in Applied Biology, Hair Growth Treatment, Minoxidil Products
As a reminder, Follicle Thought does not endorse any product/treatment unless specified. Many people have asked for this information and it’s now given.
I do not know the anticipated cost of the product yet, but I will get that info soon or closer to product launch time depending on what the response is.
Yes I would like to try it
Any amazing end of year news? How can I purchase Sult1a1?
Bubs, not at the moment, but hopefully some good news rolls around. I’ve heard you can do early ordering of Sult by emailing info@appliedbiology.com per the comments here.
The peer reviewed paper shows an increase in the enzyme, but does it show a proof that it actually boosts minox effects?
Mike, as noted the company is doing additional studies to compare minox vs minox + booster in terms of regrowth. Should be out at beginning of 2021.
Thanks, I feel good about this. How do you pronounce SULT1A1?
Sult-1-A-1
Thanks. If it’s only SULT-1-A-1 with not clever leetspeak then it looks like an internal codename (SULfoTransferase 1A1) but I can’t imagine marketing allowing that as the final product name…
Admin,
Have you any idea of the anticapted cost per bottle of this ?
Thanks.
Amazing product
But what about the side effects of SULT1A1?
What is the duration of use to get effective results?
Will my hair fall out again after stopping treatment?
What is the cost of the product?
What country will this be available in? Can we get it in the UK/EU?
I believe the mail order sales will be based in the US but I’m sure it will ship internationally.
Admin,
Were you given any explanation why there were several patients (7 of 19) that had dramatic decrease in sulfotransferase activity? Reading this study, it would suggest it might make Minoxidil less effective for a significant portion of users.
I was not carsonjz, but am happy to ask Dr. Goren that when I get a chance next.
Hi, thanks for new info! What will this mean
As far as results. Did the study look at increase in hair re growth or anything like that. Sorry I m new to this study and really don’t know what they major implications are? Cheers jack
I am going buy it.
Basically you have to apply it before use of minoxidil.
I could imagine that non responders have the highest increase as they have hardly anything to begin with. Just a guess of course
Really disappointed they’re are no clinical trials showing increased hair counts by using this product in conjunction with minoxidil. It seems like the same sort nonsense you read on shampoo bottles. “Proven to support healthy hair” That should be a red flag to any critical thinker. “SUPPORT” this means nothing. It’s like reading a vitamin bottle. If this worked they would show the hair growth data.
I wouldn’t expect an increased hair count from a minoxidil booster, only some measure of increased hair thickness and length…
Any news on sulfotransferase enzyme testing?
Dale, I know the MinoxiStyle brand has a test coming out, I don’t know when it will release.
So, if I get this right, the same team of scientists explored another possible way to increase follicular sulfotransferase (SULT1A1) activity, which involved tretinoin, but the MinoxiBoost product announced in this post uses liposomal sodium bicarbonate instead?
I believe that’s right Dale.
In the study, only 3 of 9 men had an enzyme increase:
0.938 – 0.954 (+16)
0.484 – 0.657 (+173)
0.110 – 0.159 (+49)
The rest of the men had significant decreases:
0.727 – 0.291 (-436)
0.678 – 0.162 (-516)
0.623 – 0.127 (-496)
0.510 – 0.347 (-163)
0.254 – 0.186 (-68)
0.179 – 0.090 (-89)
And that’s after only 2 weeks of use! For a minoxidil non-responder, this topical is hammering the final nail in the coffin.
I’m trying to stay optimistic and positive but these results are ridiculously bad…
I think so!???
Toccata’s findings (one of the comments above) are disturbing.. Admin what do you about them? It seems for most men it makes things worse?
Yeah, it is a meme it is the very same product as in that study. Basically just liposomal baking soda to adjust the PH. And they were so lazy they did not even compare before/after PH of the hair follicle to have an indicator as to who responds to this…
So using this product, particularly as men, would be just russian roulette. Well assuming there is nothing else in that product that hinder it from reducing the sulfotransferase.
I was hyped about this product. The chance that this might decrease enzymes, well that makes this product SHIT.
Is there any before and after pictures as that would be helpful also does it say you need to wash the the hair booster out after 30 mins and then dry the hair before applying minoxidil.
What are you talking about Jan?
sorry Admin my mistake, ok Can anyone explain when sytemson i going to start human trialś? in 3-4 years?
it’s a cosmetic product like any other: probably expensive and ineffective. don’t put just anything on your hair.
I looked at the numbers in the study and my takeaway is that subjects with low SULT1A1 activity experienced an increase or no effect but subjects with high activity experienced a decrease in activity or no effect, so it would seem that this product will only benefit non-respondents. Maybe they should only recommended it to subjects whose sulfotransferase activity has been measured and demonstrated to be low.
Admin, from the study I also learned that SULT1A1 is the scientific name or shorthand for sulfotransferase enzymes, so it seems even less likely to me now that they are going to use that as the product name…
That’s an interesting point Dale, I will confer with Dr. Goren before the product launches and clarify the article about that. Though, one of the males with a high level .9 did still show a small increase.
Only less than 50% of the test subjects experienced hair increase, and the product works better in female. Disappointing to be honest, but I’ll give it a try when it comes out. At least it seems you don’t need to use the product for several months to see results.
how can you buy those products?
Well, is this the first time that anticipated product actually is released? 😀
This treatment was made for females from the start. Even said that on the website, I don’t know why everyone is shocked
Where did it say that Dimitri? Thanks
When you go on to their appliedbiolody.com site, it says the study they did was for female pattern baldness. Not for males. It didnt specifically say it didnt work for men, but I’m sure there’s a reason the study was geared towards women.
@FollicleThough what treatments could come out in 2021? everything feels a bit quiet now
HairClone almost for sure. Not sure about what else D1, but will update this comment if I think of more.
Admin hairclone will be a real cure?
Have you had an update from Hairclone recently by any chance?
Nothing at the moment, Matthew. Will follow up when the news comes.
Hey FT, hope you’re doing well! Got a few questions regarding HairClone if thats okay!
What makes you confident HairClone will come to market next year? Would they not have to clinical trials before?
What makes this treatment unique from others that have failed? I’m sure I’ve heard of other companies trying DP cells without results or with insignificant results.
Has cost etc been announced? (I know they announced the initial banking and continued banking cost)
Although I’m not particularly sold on HairClone.. yet, I may give it a go when it comes out as I’m from England and its probably going to be the only therapy that comes to us first, I’m sure other on here would appreciate a fellow FT user giving their experience in anticipation of it coming to their respective countries.
As always, thanks for keeping us all up to date!
whats happened to Tissuse J Hewitt? follica phase 3 has been delayed to start in 2021
Hi D1, where did you read that Follica’s phase 3 has been delayed? Thanks!
Puretech website
Cheers! I checked their website as well now and it says that Follica’s product consists of the combination of an investigational device + new drug. I think at some point they were mentioning “existing drug” on their website, which is when everyone concluded that it would be just Minox.
tissuse will start human trails next year, probably
How do you know?
i guess histogen might get sped up if results are strong in december
the cassiopeia website says breezula phase 3 will start in 2020 which is good
Yoda will give this a pass, unless compelling evidence comes out that causes me to rethink otherwise. I was a good responder to topical minox in varying increasing strengths over the years. Now it’s oral minox that has restarted my minox response. Still using topical as well with other goodies mixed in. If in time I come to believe from evidence that this would be a good addition to my regime I’d add it in, just not convinced that’s the case at this point in time.
Hi Yoda, first I was optimistic. But then I found two studies yesterday about two mechanisms that also increase the sulfotransferase enzyme. Trenitoin and microneedling. Andy Goren from AB was a co-author in both studies. Having said this, I have not read the studies yet.
I also contacted AB to ask about a minox response test in my country. Instead of answering my query they came back offering me this minox booster (pre launch sale). Three months supply minimum (3 Bottles) at an introductory price of 49USD per bottle.
This response is so unprofessional..its just ridiculous.
My guess is MRKA that the company received a flood of emails in the last 2 days and are using a “copy and paste” response to deal with any email that mentions AB-103. I’m sure they do not have an extensive customer service unit at this time. You can always try emailing them again.
Hi Yoda. Oral minox is something I’ve briefly tried myself but scared myself away from it. Have you noticed any negative effects? My sensible head is concerned about heart health, and my vanity concerned with collagen depletion.
I have read that an estimated 2% of topical minoxidil goes systemic. So by my calculations, if you were applying 1ml of 5% minox, twice a day, you would possibly have 2mg of minoxidil circulating your system. If this is the case, I would be much more inclined to jump back on the low dose of 1.25mg of oral minox. Can anyone corroborate or refute this?
Yes, minor sides which can vary from person to person. At 5mg it had a negligible effect on BP, Yoda is borderline high so this is a positive. Slight fluid retention and increased body hair that plateaued. Due to the positive effect on my BP Yoda bumped up to 10mg, slightly more fluid retention so I went on a diuretic which also had a positive effect on BP and knocked out the fluid retention. As far as collagen depletion, none and I think that is a myth, the studies I’ve seen are weak and I don’t put stock in internet reports (cope to blame aging on minox). I’ve been on topical minox since the mid 80’s with high concentrations of 15% since the mid 90’s and oral for ablut 2 years. I’m soon to be 58 and people always comment on what great skin I have, youthful appearance. Eat right, exercise, don’t smoke, get sleep, take care of your skin and you’ll be fine. If not you can blame it on minoxidil! 😉
Also, Yoda does oral minox and the diuretic under a doctor’s supervision. You should too, don’t pay games or use the internet to self prescribe.
The main problem with oral minoxidil is the lack of long term data on heart lesions. The final FDA report in the 70’s said it warranted further study as the dog studies had shown abnormal heart lesions. The monkey and few human autopsies didn’t show any heart lesions though. The problem is oral minoxidil was quickly superseded and is rarely used so there really is little data on its long term effects.. Probably fine, but most cardiologists would be reluctant to prescribe it. Especially over 2mg.
I find it odd that half of the responders had their sulfanizine reduced by using it. That’s not good. Too big of a risk to try it if it ends up lowering that enzyme and making minox work less effective than it does now
If it will be cheap, I would probably try it just once a day. If I see any bad signs – bye bye. If I will see positive change I will try it twice a day. However product, that gives you 50/50 change to either help you or to do more damage? That is quite sheitty marketing.
thanks for the info tho admin
So, being female, admittedly this new advance is better for me. Theoretically worth the application, especially considering the possibly nil response I’ve had to the minoxidil I use. However, this particular product won’t be worth the money. The scientists at Applied Biology literally figured out that topical tretinoin helps with minoxidil response, and are hoping that nobody reads their previous study about it (https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12915) so that they can rebrand it as their own formula. They basically put adapalene in a spray bottle and jacked up the price.
Hey everyone, thanks for your comments and introspection on this news.
Dr. Goren reviewed the article yesterday and sent this comment to me. I will relay the important questions you all have to him at the beginning of next week.
“The response to minoxidil based on sulfotrasnferase activity is a dichotomous outcome. OD<0.4 are likely not to respond vs OD>=0.4 are likely to respond. OD represents optical density which is a measure of the enzyme activity. Several papers are published on this subject (see below). The novel booster was able to up regulate the SULT1A1 enzyme up to 7 times. Subjects with higher OD have larger SULT1A1 reading variability but only 1 was converted to a non-responder. More importantly, the average non-responder, became a responder; OD<0.2 was converted on average to OD>0.4.
Finally, we are conducting several studies to demonstrate increased hair growth when the booster is used with minoxidil compared to minoxidil mono-therapy.“
When are we expecting to see the results from this “hair growth when the booster is used with minoxidil compared to minoxidil mono-therapy” Study? Its the only study worth ANYTHING.
If I read this correctly, they are releasing a product before they’ve concluded their studies? Important, if not the only studies that really matter, when used in conjunction with minox. If so, another red flag in Yoda’s eyes.
Not exactly, they’ve already completed the sulfotransferase study as linked in the article Yoda. It’s been proven that upping the sulfo enzymes improves minoxidil response. Also, product officially launches around January, I’m not sure when study results will be in.
Right, I understand about sulfo but we are still waiting to see how it works with topical minox, no guarantees that specific product does until we have the data. Official launch but they are still selling now? Sorry, I forget is this an FDA approved product/drug or a cosmetic product?
Isn’t the active ingredient already available? they’ve just put it into this shampoo.. would make sense that its just an OTC cosmetic thats not looking for FDA approval. Could be wrong though.
Either way, hope those who use minoxidil can get some benefit out of it. I must admit though, I find it a little worrying that we’re now going to have another chemical which interacts with another drug that we still don’t fully understand after all these years. Minox’s link to left ventricle hyperthropy is already scary enough lol, mass increases of up to 50% is not good.. at all.
Also, I think you’re making the prudent move Yoda to wait until you need this shampoo (if you ever do) or theres more evidence behind it all. If you’re having success, no need to add in anything which could potentially effect it negatively.
It’s an OTC product.
Sorry where is the study showing that by upping sulfo enzymes it improves minoxidil response?
Here you go r, https://pubmed.ncbi.nlm.nih.gov/24283387/
Hi admin,
Thanks for the update.
Do you know if it synergizes with oral minox too?
Tkanks
No it wont. It’s to aid those who use topical minox and have low amounts of the enzyme that converts it.
With Oral minox it metabolises in the liver via 4 pathways.. sulphation being a minor one.
(glucuronidation (67%), hydroxylation (25%), sulphation, and conversion to an uncharacterized polar compound.)
Only other context I’d add is that before I hopped on the oral minox train I tried minoxidil sulfate from a reputable source. This is supposed to work on those who don’t have the sulfotransferase enzyme in the scalp (not sure I stated that eloquently but you get the gist). It had zero effect on me. However, remember that I was a previous responder to minox, that the effect waned. I’m not passing judgement on this OTC product either way until we have more data/results.
@FollicleThought what happened to that company in LA?
Same answer as before D1, unless I share an update on the site. I keep hope for it though.
Bit off topic but thought Id share this to anyone looking for a regime without minox for various reasons (application, family history of heart issues, bad experience with it previously etc)
https://www.reddit.com/r/tressless/comments/jg3cfd/6_month_hairline_results_dutasteride_and/
His results look amazing for only 6 months, . Obviously using dut may scare some off, I myself am very cautious when it comes to anti-androgens but for results like that – it seems worth a shot.
Hope everyone is well!
???
Tsuji doesn’t need organ technology. He has all the information he’s gathered throughout the years, if organ technology has gone bankrupt tsuji can sell the intellectual property. We have nothing to worry about 🙂
i read some commments that Tsuji didint fiinish preclincal work, so there was no chance to start human trail this or next year, i hope he will continue his work in riken
You seem blindly optimistic pal, Tsuji doesn’t own the patents.. the company who filed the patents do. But more to the point, if Tsujis methods failed.. why is any of it relevant?
Whta Tsuji is doing in Riken?
Thinningontop you don’t know that. they definitely have patents that would be really stupid not to. If tsuji doesn’t have the patents then organ technology will sell the patients to another company that will move this forward. It’s not really optimism it’s more common sense this time
in my opinion hair cloning just failed Woofy, I wonder what is the difference between stemson and tsuji?
Jan you have zero evidence it has failed. Bankruptcy doesn’t mean complete and permanent failure.
Agreed, I actually watched this video recently, its worth a watch for sure.. in fact I thin I saw your name in the comments of one if their over recent videos jan! – https://www.youtube.com/watch?v=mW0XqbKAUdw
Whats interesting is they say that a lot of hair transplant surgeons have realised that transplanted hair changes over time when moved to a different part of the scalp. They say that even though DP cells for the follicle are ‘DHT resistant’ the tissue they’re transplanted to realises negative growth factors that make them shrink again.
So even if you had DHT resistant cloned hair, you’d have to treat the area you’re moving it to.
There’s also some other interesting insight in there. Like they discovered that hairs that are preprogrammed to die actually die in groups, so one starts to thing and it essentially tells the others in that local area too thin. Would explain balding patterns etc. It’s great that they’re finding out new things, but also very daunting that they’re still so much we don’t know.
Hopefully we get a better treatment in the future, hair cloning is essentially useless if the tissue its being implanted into can’t be treated if I’m understanding the video correctly.
Yes I do.. https://patents.justia.com/assignee/organ-technologies-inc
Organ Technologies owns everyone of the patents.. this is nearly always the case in these industries.
From what I’m aware, you can’t just buy a patent. You have to buy the company that owns them. No sensible company would buy another company for a patent which has produced 0 results and has competitors.
Why would you pay millions for something you wouldn’t be able to bring to market for years, when that patent expires in years. Seems nonsensical.
Balding sucks, but don’t get too invested in these potential treatments until you see the results – my mindset is its always better to have a nice surprise, rather than a bitter disappointment.
why Tsuji said 2020 date realese? i do not understand, we are at least ten years from hair cloning if ever
i’m so looking forward to the day when the webmaster will post the article “a new medical treatment against AGA has finally officially been released”…
think it’ll be one of the best days of my life ???
Ok…what could be the best strategy now?
People who don’t want to microneedle should get a minox response test done.
If they are non responders there is no harm to use the minox booster. After a few weeks the test should be repeated to see if there is an increase of the sulfotransferase enzyme.
If you are a natural minox responder you could also get a response test done and use the minox booster afterwards. After a few weeks a second response test to see if there is an increase or decrease.
3. Microneedler can use the same strategy ie. testing before use of the booster and after a few weeks to see if there is a difference.
The big question..where can it be done?
A dermatologist perhaps?
The AB website states that the test is not for sale in the US. That is a problem for some.
I assume it can be purchased directly from AB.
I will ring them next week to get an answer.
My email was not successful.
In summary, with a response test a number of people could benefit from it…better than nothing.
BioTE Hair Rescue
https://cunninghamclinicstore.com/product/biote-hair-rescue-activate
Admin
What is your evaluation of this product, peptide, PTD-DBM, the active ingredient in the treatment of baldness?
Ahmed, I don’t know anything about that product.
how Stemson can create dht resistent cells from blood? sorry Admin for off top
sorry hair follicles 😛
Follicle thought how come you never post my comments.
Hi Marc, you were banned because of your rude comments. Sorry. And it was your insinuations, not just the fact you don’t think cloning is coming out. Take care.
Maf Fef?
What jan?
Hi follicle thought have you seen this? https://www.sciencedaily.com/releases/2020/10/201013124127.htm
Yes, years and years if anything.
I know it’s extremely early and not even in trials but I just wanted to sure because it’s still interesting.
Woofy do You know if stemson will start human trials next year?
Doubt it, In the video on ISHRS’s youtube with the CSO of Stemson (Alexey Terskikh, PhD) he said itits going to be at least 4/5 years until its released, but probably longer. He also mentioned that they’ve still got technical issues to solve in regarding to both cell types.
As far as Im aware, they’re not even in pre-clinical trials yet. They’re still in the research and development phase. I’d imagine its going to be at least a couple years until it gets to clinical trials.. if they can solve the technical issues.
I’d imagine it’s about a decade away, if ever.
Jan I have no idea.
Admin, Riken published this article today, what does this mean for the whole project ?
https://www.nature.com/articles/s42003-020-01365-7
Hey Paul, it would seem that its’ indicating that the skin in certain area’s play a role in the process. This videos worth a watch as it touches on something similar – https://www.youtube.com/watch?v=mW0XqbKAUdw
They touch on the fact that DHT resistant hairs have thinned when moved to the recipients area after x amount of years, its’ something alot of surgeons are seeing and talking about. They theorise its to do with the tissue in them areas release ‘negative growth factors’ which lead to the transplanted hairs thinning. Its all very interesting tbh, although its another hurdle.. it’s good news in my opinion, you can only create a solution a problem once you’ve identified the problem. Thats the way I see it.
the skin on the top of the head i different than the one on the back
https://www.eurekalert.org/pub_releases/2020-10/r-nas103020.php
At the moment, Paul there is no clear direct correlation between this paper and the hair follicle project. Thanks for sharing though.
@Admin do you know the mentioned ROHTO Pharmaceutical ?? They say they work on Stem Cells since many years and their 2019 company report shows commercialization of Hair Groth products.
https://www.rohto.co.jp/-/media/cojp/news/whatsnew/2019/hv_report2019_en.pdf
Hi John, it looks like they’re hair programs are very early, I had not heard of them before, thanks for sharing.
Thinningontop that’s not good news at all lol. Also so dht resident hair when transplanted I’ve heard last 10 to 20 years that’s a very long time. All you need to do is go to a place were they freeze your dht resistant hairs like what that British company hair clone is doing. Or you could use a treatment that turns the dying hairs back to life. Then you have unlimited hair.
I am using finasteride from past 3 months now. I am suffering from diffuse patterned thinning with uniformly over top of my hear. But I am not seeing slowing in my hair loss. Anyone out here who knows probably when to expect some sort of results or something from Finasteride ?
Three months is next to nothing, possibly the start. Maybe six months up to two years. Best to be on minox as well to stimulate growth. I know it can be hard but be patient!
Oceavibe had a question for you up above Yoda.
Thanks for the heads up Admin, I would’ve never seen that. Another chance for Yoda to bloviate! 🙂
Thanks Yoda, very helpful.
sorry for off top but maybe someone know how can Stemson th create dht resistant hairs from blood cells??
Jan, this hasn’t been answered yet. I might add it’s not the most important point at the moment, if Stemson could create an unlimited amount of DHT-susceptible hairs it would still be the biggest breakthrough that hair science has ever seen and would effectively be a complete cure for everyone. How long does it take scalp hairs to start to miniaturize, 18 years for some? 20-30 years for most?
I think people are on here moaning and groaning. I said this for the hundredth time, the only problem not solved is the direction and hair quality issue. when hairs where reinfected back into scalps, they grew in different directions and looked unnatural. thats what Stemson got the investment for was to solve the directional issue not the inductivity issue. read this. now given tsuji is out, I expect hair cloning to be out before 2030-2035 for the rich and after 2040 for average Americans. But do I think hair loss will be cured within the decade, of course. every year they’re finding new pathways to find the root of baldness. its kind of crazy when you think about it. And success is only dictated by your financial runway. Most labs are heavily underfunded and had they been funded a little more success would have been pretty close. Tesla almost went bankrupt 3 times and took 20 years to be worth 400 billion. Elon dumped billions of his own money into the company. there aren’t alot of people in medicine willing to do that.
“The basic idea of hair cloning is that healthy follicle cells or dermal papillae can be extracted from the subject from areas that are not bald and are not suffering hair loss, they can be multiplied (cloned) by various culturing methods[1] and the newly produced cells can be injected back in the bald scalp, where they would act healthy and produce hair. In 2015, initial trials for human hair were successful in generating new follicles[2], but the hairs grew in various different directions giving an unnatural look. As of 2019, scientists believe they may have solved this problem by using nearly microscopic 3D printed shafts to assist follicles growing upward through the scalp. This technique however is still in research phase and is not available for public or commercial use.”
You sure Tsuji is out Jake?
No one knows for sure Tom, except for Tsuji and a small circle around him.
Jan, please stop spamming one word sentences in the comments section and endless posts about hair cloning. What is known has been covered multiple times. Thank you.
And apparently one other guy who’s posting on this blog. Man, and I thought Yoda was a windbag! 😉
honestly you can only do research so long. As a researcher I feel like I know what happened. Organ technologies ceo mismanaged funds, figured out they didnt have enough money to work out the “last minute kinks”, and after tsuji found out he left. I think from April up until now the Ceo was trying to shore up capital but figured out nobody was interested. so he deleted the Linkedin page for the company and either closed operations or suspended it until he got further funding. honestly knowing your head researcher left after discovering your core product is a bad sign. Ive said this for years. The science works, cloning will work on humans, but I feel l like the hairs will look bad like they discovered in 2015. We’ll find out soon.
I also believe we are close to hair cloning, but if we really are that close how can you still aim for 2035? In my opinion 2025 is a fair guess. Also the real cure might come from discovering a signal that turns stem cells in our scalp in terminal hair – bald men have the same amount of cells of hairy men. All we can do is relax and enjoy the ride.
@Jan I truly undertsand the struggle but spreading pessimism and repeating the same thing over and over is not gonna help anyone
Shia 2025 is extremely optimistic scenario…..
the biggest issue is funding. most venture capital dollars are geared toward high margin software businesses. Not 10 year biology driven companies trying to fix insecurities of human beings. Its crazy because the returns on a hair loss cure would be ridiciouls if priced at 200,000 dollars. But most investors opt toward the easy route. I was basing my estimate on the availability of capital in the market. its easy to hire 1000 researchers up from 12 and expedite the process 20 fold but nobody would fund that. and the direction of cloned hair is a huge issue. the direction and curl pattern of hair is dictated by the shape of the follicle. So if you have curly hair and you cloned hair and injected the cells back in bald areas, because there isn’t a structure to form the follicle, your hair could end up straight in all different directions. Which is what they found in 2015. Fixing direction is fairly easy, fixing shape is super hard because everybody has a different shaped hair follicle that determines if my hair is curly and your hair is straight. how they fix that, I have no idea. even the slightest mm off creates pubic hair like shafts on your scalp.
And I agree, I think we need to focus more on the pathway signals. The issue is most scientists are focussing on one signal. Like an on or off switch. What they fail to realize is that hair loss is caused by a series of perfectly timed events. 7 I think. 7 things have to be perfectly timed on your scalp and all fail for you to have hair loss. Turning on one signal won’t fix the issue, turning all of them on will. What we’re starting to realize is the skin on your scalp and muscles on your scalp may be the reason for your hair loss. your skin on your scalp regulates the growth of your hair. If it gets a failed signal it puts your hair into hibernation forever, overproduces sebum(dandruff) and gives you that shiny hair look. That shiny bald looks is basically built up sebum. When your born, 6 months after birth your hair is pre programmed to die like male pattern baldness, but shifts back to growth 6 month later. There lies the cure. Instead of a cream, you would need a series of injections that thermoregulate your scalp and flip your stem cells to start producing hair. People also dont realize that rats have different skin stem cells than humans. Thats why the science doesn’t match up from mice to humans when trials are run. Scalp skin is relatively thicker. I have a hunch that dht doesn’t shrink your scalp but regulates your skin. If you look alot of people who took finasteride for a long time look younger than they are. Also research is so fragmented. You have research labs competing with each other releasing 100 page articles that take forever to decipher. If you made a company, hired the best researchers and 1000 college stuff to run simulations, you’d find the pathways and cure baldness. But that would cost 100 million a year in salary and laboratory costs so its not economically feasible.
@jake if 7 things have to fail, you just have to find a couple and block them happening. what do you think of histogen? its this pretty similar to the injectable growth things you are suggesting?
@Jake also what do you think of the WAY analog by Guiliani?
Jake, do you think Razzels is a gum or a candy?
I thought stemson solved the hair direction problem as well as tsuji
Agree re:funding and research, really winds me up why some company or billionaire can’t make it their ambition e.g Tesla, and pump the money in to just hire a shed load of scientists to go at it day and night, use AI systems to identify drug candidates, use south america etc to ram through trials, just expedite the whole damn process and get the job done!
The scenario you described is a great idea Mutruk! Let’s hope someone takes an initiative like this or similar now!
I’ve been saying the same thing Mutruk! These hairloss companies in the pipeline need to take the initiative and contact celebrities/rich figures especially those that are suffering from any form of hairloss of thinning. Because they would have definate interest in finding a cure/ better alternative to current treatments.
For example, a company has got partnered with ultra celeb Cristiano Ronaldo !!! You don’t get a bigger celebrity than him. His the most followed person on Instagram in the world, yet a hairloss company called “Insparya Group” has partnered which such a enormous super star, surely other hair loss companies can take the initiative to pitch their treatments to other millionaires/billionaires/ celebrities experiencing hairloss of any sort male or female.
For example, NBA superstar LeBron James has been known for suffering from MPB for years and has been heavily insecure about it. Even Justin Beiber has been experiencing MPB with major thinning compared to his younger days of this full head of hair. There’s a wide variety of celebrities to choose from: Sport, Music, Fashion, Aesthetics/Fitness, TV, Entertainment, Movies, etc.
It’s really not impossible to get in touch with celebrities and or millionaires and even billionaires. Celebrities have agents, managers or publicists.
Instead of the hairloss companies just posting an advert looking for partnerships/funding/investors via hair loss forums or on their website, they should physically search for millionaires/billionaires/celebrities (mainly those that have experienced some sort of MPB) and schedule a meeting with them or their manager/agent/publicist regarding a business opportunity to partner with them. They could send broadcast emails to hundreds of celebrities/millionaires/billionaires at the same time and even if they only get a handful of responses, its way better than them only reaching a far smaller and less financially equipped audience.
Theres many millionaires/billionaires suffering from MPB but they simply don’t know what hairloss treatments are in the pipeline because they surely didn’t get that rich spending their time reading hairloss forums. They need to be enlightened about the possible solutions on the horizon and it should not be taken for granted that they already know because I’m pretty sure most are unaware. These rich people also love getting good business opportunities to partner because they have the funding so pitching their treatments well is also key.
No need to apologize Jan, if you continue you know what to expect. Multiple others have complained about it now.
are you still in contact with J. Hewitt? can you ask for an uodate? Even if they still need time. A quick update would be nice
Admin, any news on Rivertown therapeutics and rt1640? Had a lot of hope built up but the website is non existent now and been pretty quiet recently except for a few studies on mice but it has already been trialed on humans I’m guessing they are still struggling for funding for clinical trials?
@FollicleThought
Apart from triple hair and SULT1a1, are there any more products to look forward to that are potentially releasing in 2021?
Not that I know of Nick for now..
Isn’t hairclone releasing in 2021?
It’s very likely that they should be Dimitri, yes.
Unfortunately it is hard to be optimistic at the moment. There will be nothing new on the market for atleast 3 years. It feels like we are actually in a worse scenario than 2 years ago
like I said, I think hair cloning works without a doubt but I think the hairs the lab is currently producing are shit. The hairs their currently producing look like pubic hair. I’ve read the studies and seen the research. Do I think it will ever get solved. Of course if the money to fund it is there. how long it takes I have no idea. i dont think 2025 is realistic. I see 2030 to be a more appropriate time frame. By then we have quantum computers to run simulations, scientific tooling is magnitudes better. Think about it like this, in the 90’s they didnt have the tools to extract single grafts, it took 10 years to develop the tools before we could start studying the effects of a single graft in other parts of the body. Its more important to focus on creating the instruments than tools to get to it than begging scientists for a cure.
I dont see why they cant make a treatment from injecting adipose fat cells. It seems to me that it is autologous
Jake, what is you humble opinion on Hairclones strategy to inject multiplied DP cells into thinning hair to rejuvenate them?
its as shitty as replicel. DP are responsible for hair growth, but its regulated by stem cells, sebaceous glands and surrounding skin tissue. Injecting DP cells when the true issues are related to one of these regulators being turned off or mutated is a shit model. Will never work. Its one of those 10% efficacy experiments.
Ok correct me if I’m wrong but is it not the DP cells in the hairs in balding regions that are adversely affected by dht and that the DP cell population reduces resulting in miniaturisation? Hence why finasteride works for many.
its not the dp cells. what we found running clinical trials, is that it is DP cell issues for mice. But I have a hunch that dht changes the behavior of scalp and muscle in the scalp that send nerve signals to the stem cells in follicles to shut off. Dont believe all this head shape none sense. Theres people of all shaped heads that have hair.
@Jake if it was just a case of one of the regulators being turned off hair loss would be much easier to fix you would have thought
Its not. What scientists found 5 years ago at Columbia University is its not just one regulator that’s turned off its multiple. Some doctors think your skin is sending signals to shrink your hair follicle. Other think its fat cells, others think its the galea and compression of the scalp. And so many think its stem cells. When really its all of these. And trying to perfect dosages and close the pathways all at once is like trying to find 10 needles in a gigantic haystack that dont have markers. Had there been more funding and thousands of researchers working on it, we would of had a cure by now no doubt in my mind
@Jake Yes I’ve seen a few of the headshape/gravity and other fringe theories that seem a little far fetched. The Rob guy from PHH has some interesting ideas about chronic muscle tension resulting in chronic immflamation which increases localised DHT levels and causes ‘calcification’ of the subcutaneous layer etc. Although he gets slated alot I think there is some validity to some of his ideas. Anecdotally, a colleague in his late 20’s who’s a full blown NW6 has the most pronounced Temporalis muscles I’ve ever seen which would support the idea of chronic tension.
That’s already done in clinics, some decent results ..Vie aesthetics
Research going slow but hair loss is at its speed.
Admin do you think treatment from Kintor or Breezula will be able to reverse hair loss up to certain point?
I think may be any of these two would be available in next year.
Hi Devit, I would only say that they would be able to reverse hair loss similar to finasteride, but likely slightly less than finasteride’s full potential.
hi matt and admin
do you think hairclone rejuvenation treatment will completely stop further hair loss and more effective than finasteride? ( better than finasteride)
gill, I don’t think hairclone will completely stop further loss, but with continual treatments, say over the course of 2-3 years it will be interesting to see what kind of results can come. We can only really wait for the data.
Does anyone know what Norwood levels Histogen wanted for there 36 person trial? Thanks
I got a question, why did intercytex/aderans/replicel work in mice but not work in humans
Mice tend to respond very well to most types of treatments because they are different genetically than humans and I think perhaps the model of androgenic alopecia cannot be perfectly replicated in a mouse.
Thought this might be interesting to some.
https://stemsontx.com/stemson-target-uk-for-expansion-of-research-and-development-with-backing-of-impact-investor-fortunis-capital/
If you read through it seems they’re looking to carry R&D out and potentially trials in the UK .
Found this very interesting, mainly due to the fact hairclone is already based in the UK and stemson could now potentially have some sort of expedited trials. We’re outside the EU now so don’t have to follow any of their guidelines (if there are any) so it seems the UK government could take aim to become the equivalent of japan in the west when it comes to this type of research, hopefully they decide to do so and make the regulatory process favourable.
As a member of the EU the UK already had a “flexible” approach. This seems to be key to what HairClone (UK company) is proposing for next year. Could you explain why leaving the EU will provide an advantage in this context? Also, people always assume regulation is a bad thing, when it is in fact there to protect people from drugs and processes and that might otherwise damage their health. The vaccines for Covid are going through the normal regulatory checking processes, but huge resources and efforts are obviously being put into getting the approvals, and it is that which is speeding things along. In the context of vaccine development, the UK is bound by EU regulatory processes until end of this year and I have yet to read of anything which suggests this has proved a hindrance in any way.
For all of you that wanted an update from Kyocera. If I had to give it my best guess, they’ll either sell the technology to someone like Stemson or find another business partner. I think organ technologies mismanaged money. Thats my best guess.
“I checked with Kyocera’s global headquarters in Japan. They informed me that Kyocera’s joint research agreement with RIKEN and Organ Technologies on “Treating Alopecia by Hair Follicle Organ Regeneration” has been completed; and, Kyocera has also completed its development of hair follicle cell processing technology. Kyocera had planned to consider commercializating its technology based on the results of clinical research and experiments led by Organ Technologies. However, since Organ Technologies recently suspended its business, Kyocera has decided to postpone the commercialization of hair follicle regeneration technology until further notice.”
I got another response after I asked if they’d partner with someone new. this is what I got
“Hello again, and thank you once again for your sincere interest in this area. Although technically, anything is possible, Kyocera has no further plans to announce on this topic at the present time.”
@jake, would it be possible for you to post a screenshot of your correspondence with riken or send it to the admin ?
what do you mean, this was from Kyocera not Riken? you want a screenshot of the email. I dont care ill send it if you’d like
My apologies jake, I meant Kyocera. That would be great if you don’t mind. Also, what is your view on samumed ?
if you give me an email sure, I dont really care tbh, there isnt much to lie about. haven’t done much research on samumed my focus was mainly geared towards stemson and Tsuji. look if anything sounds to good to be true it probably is, unless theres a documented research paper on it like tsuji and stemson. Look at replicel. They basically took follicle outer layer cells hoping they’d regenerate follicles. If anybody new anything about science, you know the stem cells for hair are not located at the bottom of the hair follicle but at the tip near the skin next to the sweat glands and oil glands.
I sent Jake an email, not sure if he received it.
LOL. “We have the cure. We just don’t want to give it to you.” Sounds like BS to me. If they could cure MPB they would be running to the press with it, it would receive financial backing almost instantly if they floated the knowledge out there of their product.
Hello Admin,
I can’t recall if this has been already covered.
Is the lack of sulfotransferase enzyme only an issue for topical minoxidil?
Or does the lack of the enzyme also apply to oral minoxidil?
Thanks
I wasn’t sure about that but I believe I remember someone from the audience stating that it was only an issue for topical minoxidil. In time I can run that question by Dr. Goren.
My recollection from what I read is that it only applies to topical. Something about the liver and the process it plays with the sulfotransferase enzyme. Oral minox has been a life saver for Yoda as topical has lost it’s effectiveness. That being said, I still use topical to be safe as well as the solutions I use have other ingredients in them.
Thanks Yoda,
I reviewed a few articles today. It appears that only topical minox has an issue with the enzyme.
That may explain the better response to oral minox.
I will try oral minox (either 2.5 or 5mg) soon if I can obtain it. Hopefully no side effects.
So much easier, no greasy hair (altough I was thinking about foam), no worrying if absorption needling is a good additional treatment, time savings etc.
Fingers crossed
You bet MRKA, as always Yoda recommends you consult with a doctor before starting oral minox. It can be a powerful drug.
Thanks admin. hopefully when Jake has time, he will send his correspondence to you.
https://www.dropbox.com/s/9plnxlan6tpxd2b/Screen%20Shot%202020-11-16%20at%206.41.39%20PM.png?dl=0
https://www.dropbox.com/s/2lspwuz5xd0jkrb/Screen%20Shot%202020-11-16%20at%206.42.05%20PM.png?dl=0
I crossed out the name out of courtesy.
Hey Yoda, what dutasteride brand do you use?
Generic…I’ve used branded Avodart as well. No notice of any difference. Please consult with a doctor before starting dut Woofy.
Ok thanks yoda
Hey Admin,
Any update on when we’ll see new results from follica? That’s supposed to be releasing soon, no?
follica hasnt even STARTED phase three yet, despite being ready for it since last year. its at least 2 years away, but probably more.
Hi Stef, Follica is still yet to begin a phase 3 trial. Maybe they will begin in Jan-Feb 2021.
Histogen’s phase 1a2b finishes on dec 3
https://link.springer.com/article/10.1007/s11626-020-00513-x
Might be of interest to some of you – this is TissUse, right?
Well damn. I thought they were at the finish line. Will we at least be seeing phase 2 results from Follca before they move to phase 3?
Timeline Reminder: FDA approval process alone takes 12 months.
As a case study, Cassiopea’s Winlevi began phase 3 in 2015—Readout 2018—FDA submission 2019—Approved 2020—Now they plan to release in 2021. The stronger cream for Baldness (called Breezula) has not yet begun phase 3. It follows that upon initiation of phase 3, expect an additional 5-6 years until it is actually released for prescription.
Similarily, Gelesis aka Plenity (Puretech) finished phase 3 in 2017 and now plan to release in 2021. Puretech also owns Follica. Once more, after Follica’s phase 3 is finished, add another 3-4 years for approval and launch.
I know the hope is a 6 month phase 3 study, immediate data readout and FDA submission, a couple months for approval, and boom! launch a few weeks after—year or two at most: 2022-23, but real world number-crunching suggests otherwise. Samumed, Follicum, Breezula, and Follica are the closest topicals I know, but none sooner than 2024. *If Samumed finishes phase 3 in 2021, submits the same year and gets FDA approval by late 2022, they could be on the market in 2023 at the absolute earliest.* (Follicum is still in Phase 2, Breezula and Follica are awaiting Phase 3).
Plan your regimen accordingly.
Toccata is right. I started losing hair around 2013 and I thought for sure by 2020 we would have at least replicel, follica, and CB-03-01, but we are still at least 4 years off from ANY treatment being released. and even then, those barely work.
fin has failed to preserve my hair, only slowed the loss and given me sides. now I’m at the point of weighing just accepting baldness or getting transplant. In either case, I will be forgetting about waiting for these future treatments. I think they will be relevant for my sons if i have any, but not for me. sad truth but one that needs accepting.
I should add, Samumed began their phase 3 in 2018. If they were to actually release in 2023/24, their timeline would follow that of Winlevi’s; 5-6 years from phase 3 initiation to market launch. That dreadful, terrible, horrible and seemingly unavoidable ‘five years away’ strikes again.
Just got 3 bottles of MinoxiBoost in the mail today!?
Where did u buy ?
From applied biology, I emailed them.
I have sent them but the mail is not activated
Please send a correct email
How much does the product cost?
45 usd per bottle (1 month use). Customerservice@appliedbiology.com
I wish the FDA could just use the emergency authorization for atleast SOME treatments like Histogen or follica because this is just taking so long we haven’t had a treatment approved since 1997 they are being way to strict Histogen and Follica are safe and they work. If they weren’t safe, the trials would have stopped years ago and participants would have had problems but they don’t.
A status check-in from HairClone was added to the Updates page. Most of the information is congruent with their previous projections, but nonetheless, news has been a bit scarce lately and people have asked about HairClone recently.
Hey FT, I saw a comment about you mentioning an article about an unreleased hair growth product. But I don’t see the comment anymore. Is that still in the works?
Hi Master V, the plan has changed actually and my next article will be on a new gene therapy for hair growth and should be coming soon, thanks.
FT, thanks for the update. Looking forward to the next article. Thanks!
https://pdfs.semanticscholar.org/3c44/b36ca050e580b67436f9880776d2c136e513.pdf Has anyone seen this study before? It’s from 1987 and apparently Foltene can produce 50% regrowth for AGA.
Woofy those result suck and the pics in that study were taken in the dark haha.
Haha! Classic Mjones! 🙂 I didn’t even look at the study and will agree. 😉
Mjones ok I’ll take your word for it lol ? i didn’t see the pics.
I see them I didn’t scroll down. They actually aren’t that bad though. The lighting isn’t very good I agree.
Woofy, stick with the proven meds…the big 3 and variations of those. Anything else is like chasing windmills.
I know yoda, but I just wanted to share that.
Thanks Woofy, you’re a good guy!
You too yoda.
Histogen sold some of their stock on lower price recently, I am not stock wise but when nearing trial results…….
@Kapil
What would that even mean though? That the trials are not doing as well?
I think we will have to wait for years, the current hair growth products, which work minimally and have many side effects, are too powerful and still earn a lot of money. For example, the corona vaccine, if necessary, it can and quickly, and this is missing from the baldness problem.
It would be nice if there was a hair growth treatment that got ushered through approval process, yes. 😉
It would be very nice. We can only hope that Triple Hair, the Canadian company is able to get some good results without any side effects that match the current line up. It should be launching early next year.
Radula, I’m hopeful for triple hair too but not confident. TRH16 is resveratrol and melatonin. I already use stemoxydine with resveratrol, though im unsure how much resveratrol it contains. Maybe I’ll try to add resveratrol and melatonin to stemoxydine until triple hairs product is released. Seems too good to be true though.
We can hope Oceanvibe.
Admin, do you know what Hairclone’s “cell expansion service” is? Saw that it will probably be available in 2021.
Andre, the cell expansion service is HairClone’s process of culturing and multiplying dermal papilla cells for injection into the scalp. They only process the cells, though.
Isn’t that pretty much a regenera activa approach, and their results are shit… 🙁
Actually, no. I have no idea how well HairClone will work but HairClone cultures and multiplies dermal papilla cells while Regenera simply grinds up a few hair follicles and injects the original value of cells back into your scalp over a large area.
I am pretty sure histogen will have good phase 1/2 results. It’s pretty much a ramped up version of their original formulation from 2010 which worked. The stock buy means they probably got a good product and an outside investor is picking up shares to fund their next few trials. Just a guess of course…who knows…its mpb trials….anything could happen.
Anyone see a pattern with Jan it’s pretty obvious he’s a troll he comes on different websites and always ask the same questions about tsuji and talks negative about everything thats literally all he does zero evidence the only evidence he has is the past failures of companies that don’t mean anything. Please ban him.
This guy named Jan is probably obsessing over hair loss more than we are, and I kinda feel like hair loss has already taken some joy from my life, so I can’t help but feel sorry for someone who has it worse than me. We are all on the same boat, let’s try to not be toxic to each other. This guy obviously doesn’t think what he says, or he wouldn’t be switching from ” hair loss will never be cured ” to linking papers of researches and stuff. He just needs some encouragment
Take care everyone
Thanks for the kind words Shia.
Follicle thought so you know Dr plinkus and Dr Rassman are working on the mole molecule treatment for AGA well I asked Dr Rassman for an update and he replied “The research continues and is getting better and better. Publication expected early next year sometime”. Just wanted to share
Thank you for sharing Woofy.
Interesting story in Antiaging … can somebody tell details what exact procedure it had? Pressure? % of oxygen?
https://www.news18.com/news/buzz/hyperbaric-oxygen-treatment-could-reverse-ageing-in-humans-israeli-scientists-claim-3107615.html
Hi John, hyperbaric treatments are widely used by athletes and celebrities, I don’t think there’s groundbreaking results from them, but I haven’t researched them much. I would guess the effect is mostly a consistent slight improvement in overall well being.
I’m excited for Histogens update but they need to give us lots of pictures and how many new hair follicles per cm2. I don’t appreciate how Follica only released one picture. Changed my name btw 🙂
It’s been quiet lately but I feel like over the next two months we’ll have some more news and results?
1) Histogen finishes phase 1 and should might in December
2) Kintor finished US phase 1b and might report in December
3) Samumed finishes phase 3 in January
4) Triple Hair might release TH16 in January
Yessss, and we have still the questionable companies…Regus, Mane and the UW Madison device. Altough I admit that I only have very very limited confidence about a positive outcome. Probably more of a pipe dream..but nevertheless.
Then there is Stemore. But admin has already expressed doubts that a cosmetic stem cell derived topical will hit the market.
I will seek out an update on the Triple Hair cosmetic for you guys soon, I hope it’s been able to stay on track this year.
Dr. Tsuji had the funding could have started human trials long ago atleast 2 years ago, animal testing is not required in Japan to begin human testing according to TissUse. Dr. tsuji could have skipped that, hard to believe it takes 8 years to develop the technology and never start a human trial… we got played.
Admin, since it is coming up to a year since J.Hewitt announced that they were planning on conducting human clinical trials, is there any possibility that the CEO will give you an update on the companies progress before the end of 2020 or have you any plans on making contact before 2021? Thanks
Hi Paul, I do keep in touch with J Hewitt and will share an update when it becomes available.
Hi can you get me the information to contact them. I’ve tried by email but for some reason it’s says it not a valid email.
info@appliedbiology.com should work
Hi follicle thought, i know you have said Histogen is going to release data in December but do you know what date? Because someone told me December 3rd is that what you’ve heard? Thanks
“New research from China has been published inducing human dermal fibroblast cells into DP-like cells for hair regeneration” so who does this help? Stemson therapeutics, Christiano technique? Or does this help help RCH01 or hairclone? Or all?
Admin, what’s going on with Insilico Medicine? Any news?
This is what tretinoin do :
Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes :
https://pubmed.ncbi.nlm.nih.gov/30974011/
I would love to try it and add it to my regime. How or where do we purchase it?
Hi Nancy, someone mentioned info@appliedbiology.com is the email to contact. Thanks for reading.
Dear admin!
Are there before / after pictures that show a noticeable improvement. Thanks in advance.
Hi Nobody, no there are studies going on currently to observe hair growth improvement with minoxidil using the booster.
The above email address is currently unavailable. Does anyone else have problems with it? I would be very grateful for an answer 🙂
FYI
customerservice@appiedbiology.com🙂
info@appliedbiology.com is not a valid email to contact them anymore. And they dont respond when you email customerservice@appliedbiology.com either. No clue what’s going on with this company or product.
Ok, thanks for sharing. Let’s give it a minute as the product has not officially launched yet. I know there is going to be a separate website for the product once it launches, I’ll share the info when it’s available.
Sounds good
Hello anon!
The custom service contacted me last week and offered me a price of US $ 49 per bottle (minimum purchase of 3 bottles1) plus shipping costs
What email address did you contact?
*customer service von applied biology ! Sorry:-)
Dear admin!
As is your personal opinion, it is advisable to use minoxidil with minoxiboost from AB or a combination of minoxidil and TH-16 from triple hair. Does anyone else have any advice for me? Thanks in advance:-)
There’s no reason you couldn’t use minoxiboost + minoxidil + TH16. But, I’m not advocating for the minoxiboost product until the further studies are released.
Thank you admin:-)
Any updates on when this will be out in the market?
thanks
The update from Dr. Goren should be coming within the next 2 weeks I hope.
Hey, 2 weeks have passed. Any updates?
Not yet A man.
Dear admin!
When would the product be available in Europe? Thanks!
I will try to find out asap nobody.
The Minoxiboost website says, “Dr. Name Here is one of the most experienced hair dermatologists in the world.”
Immediately to the left of that inspiring quote they link to a video that shows two dudes reviewing Ben Shapiro’s violin skills.
It does not seem like there’s a lot of competence here.
I mean, I don’t know exactly how great the product will be, but as far as competency goes I think you found the page on the AB website that is basically dormant/unfinished. There is a page on the specific website that is functioning as far as I can tell. http://www.minoxistyle.com/MinoxiBoost.html
Dear Admnin
What is QR 678?
I’m not exactly sure, some cocktail of peptides I believe? It is a hair growth injectable used in India.
A hair growth injectable from India, count me in! 😉
I am frequent (almost daily) site visitor but posting for the first time.
Regarding QR 678, they do lot of advertising without showing any result. It is same as PRP with little advantage. (I received this from my dermatologist).
I was continuously seeing the hair restoration DHT blocking shampoo ad on this site, I see they have nice success story videos on their site. any one tried it?
(https://triplehair.ca/products/therapy-16/) “outperformed minoxidil 5% in their Phase II clinical trials”
The composition comprises 5% resveratrol and 0.1% melatonin as the active ingredients and propylene glycol and absolute ethyl alcohol as non-active ingredients. The alcohol also serves as the final preservative in the composition.”
TH16 Patent: https://patents.google.com/patent/WO2017004692A1/en#:~:text=The inventor has discovered that a composition for topical administration,loss and increasing hair regrowth.&text=Minoxidil is considered the topical,loss prevention product is finasteride.
Please update this product for availability on the website
https://rizn.ca/
Hey Yoda…reminds me of a Doctor on youtube. Same country methinks.
He stated that Dutasteride only blocks 95% of DHT as DHT is vital for muscle growth and muscle maintenance….
SMH
I remember at least 5 years ago there was a Dr., I believe his name was Nigram, who was saying he solved hair multiplication for replenishing for donor area in hair transplant procedures. He seemed very credible, attended the conferences with the hoi polloi of hair transplant docs. The whiz bang Intellligencia on a hair forum that was popular at the time went wild. One of the readers went to Nigram’s country ( I think India but not certain, in that general area though) for a procedure. Long story short, he got absolutely butchered, infection, etc. Not sure why Yoda is going off on this rant but that’s what ” a hair growth injectable used in India” reminded me of. If nothing else, there are a lot of scam out there more than willing to take the money of people desperate to find a cure, for hair loss and other diseases. I’ve seen quite a few, please be careful guys (and girls).
Seems like a big news IMO – making minox effective for 2/3 of the population instead of just 1/3 of the population.. When available to buy?
I was told by Andy Goren that they have licensed the product to a partner company and it will be launched this year, but he was not specific on the date. Follicle Thought will keep you updated for sure.
Any updates? 2 years later?
Kirsten, thanks for your question. Over the past two years, I’ve learned a bit more about sulfotransferase enzymes and potential ways of boosting them for a minoxidil response. The booster product described in this article will eventually be commercialized by a company named https://www.danielalain.com/ That said, there are several other formulas on the market with retinoic acid already included to improve minoxidil response (for example Strut Health’s womens formula which I have an article on, simply search). Also, dermarolling/microneedling improves minoxidil response. So, I don’t know when DA will market this product, but I actually don’t think it is superior to the combination of a formula with retinoic acid + microneedling. Hope this helps. Ps. I’ve heard there is also a company trialing a sulfated form of minoxidil that should not require any boosting, don’t know much further than that.
Any more on the company testing a sulfated form of minoxidil?
Kirsten, I actually know little about it and I’d have to do some digging to find who the actual company is. There was a tiny bit of news around the minoxidil booster product this week, perhaps irrelevant due to location. A Biology has been bought by Jupiter Wellness who licensed the product to a Japan Pharma co. https://www.biospace.com/article/releases/jupiter-wellness-licenses-minoxidil-booster-to-taisho/
Thank you so much. You are the best source of information on hair loss solutions! So appreciate what you do
I appreciate the kind words 🙏
Thank you so much for the update!
Have you any info on Revela? I sent them an email telling them about my negative result on the DA follicle response test and what I had heard about boosting the sulfotransferase enzyme “We are definitely aware of the sulfotransferase enzyme that you are talking about and we believe that may be one reason that ProCelinyl is so effective, as it has a methylsulfonyl group within the molecule itself.”
What do you think??!!
I don’t know much about that product Kirsten, wouldn’t necessarily take it as solid evidence if they said “that may be one reason why….” etc, but if you want to try the product, why not?
Totally understand what you are saying about their response. I think I’m going to try their product and Cel micro stem shampoo that has a retinoid in it among other good ingredients. You should check out the Revela website…they have an interesting story…seems very different than what’s out there. Thanks for all your input!