Can MicroRNA-205 Rejuvenate Human Hair Follicle Stem Cells?

A new study led by Rui Yi and fellows at Northwestern University has identified a specific miRNA (microRNA) which may play a role in hair follicle development. The study titled “MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells” was published May 22, 2023 in PNAS. Apparently, hair follicle stem cells become stiff and rigid as they age which leads to a decrease in hair growth. The Northwestern group discovered that miRNA-205 is able to soften the stem cells, which also rejuvenated their hair growth-inducing properties.

Importantly, Yi was quoted to say “Because of the potential to deliver microRNA by nanoparticles directly into the skin, next we will test whether topically delivered miR-205 can stimulate hair growth first in mice. If successful, we will design experiments to test whether this microRNA can promote hair growth potentially in humans.” The study was conducted using genetically engineered mice.