Fukuda Lab & Yokohama University: Hair Cloning Update

Healthcare Venture Award Presentation: Update (10/31/23)

Fukuda’s company TrichoSeeds was selected as a finalist at the 5th Healthcare Venture Award event which took place in Tokyo, Japan on October 27, 2023. The event featured innovative biotechnology companies from Japan, especially those which focused on extending healthspan and longevity. Follicle Thought was fortunate to capture an early snippet of the website’s description of TrichoSeeds Co. which included a timeline to a hair regeneration clinical trial. It is assumed that this description was provided by Junji Fukuda PhD to the organizers of the event.

 

Fukuda Lab Makes Headlines For Reprogramming Paper: Update (10/22/22)

Multiple media outlets jumped on the news this week when a new study on hair follicle cloning was published in a peer-reviewed journal. The paper, titled “Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction” was published by Fukuda et al. in Science Advances. Although the hair follicles produced in vitro during the study were derived from mouse cells, the techniques and protocols discovered by Fukuda could one day be applied to human hair follicle cells. According to reports, the main achievement of the study was discovering that an extracellular matrix gel (brand name Matrigel) markedly improved the development of hair follicles in culture. 

 

Junji Fukuda Starts TrichoSeeds Co. For Commercialization Of Hair Follicle Multiplication Technology: Update (1/28/22)

Nearly four years since Junji Fukuda PhD and team members at Yokohama National University made headlines for their work on a system to mass produce hair follicles, it appears that project is being taken to the next level. On November 20, 2021, Yokohama National University issued a press release in conjunction with two other research institutes detailing the establishment of TrichoSeeds Co., a new venture headed by Junji Fukuda PhD. The press release was only issued in the Japanese language, which made it difficult to find until now. I have processed the press release PDF through Google translate, so its readability is not perfect, but it allows us to understand the purpose of the press release.

(Click to view) Translated copy of Yokohama – TrichoSeeds Co Press Release

 
Original Article 

If you didn’t hear about french fries causing hair growth in the past two months you probably don’t listen to the news. 

Many of us, however, witnessed headline revelations of fried potatoes being touted as a potential new hair growth therapy. The origin of the fast food fantasies can be traced to a research paper lead by Junji Fukuda PhD and members of his lab at Yokohama National University in Japan. The research carried out by the Fukuda lab was focused on producing large scale quantities of hair-follicle germs simultaneously. The key to success, according to Fukuda, was a particular material used on the bottom of the cell-culturing chips which were designed to grow the hair-follicle germs. This ingredient is known as oxygen-permeable dimethylpolysiloxane (aka the magical McDonald’s french fry ingredient.) 

The fact that certain french fries also contain this silicone ingredient lead to the laughable correlation of eating fries and growing hair. Although the mainstream media really took this thing for a ride, there may be a reason to get excited for this research discovery. Finding methods to mass produce hair cell aggregates has long been sought after and thought of as a major obstacle to developing a treatment applicable to humans. Junji and his lab appear to have developed a viable solution for this task.

Fukuda Lab

According to its website, the Fukuda lab is a bio-microsystem laboratory focused on the applications of electrochemistry and microfabrication, micro total analysis systems, cell-based assays, and tissue engineering. Phew. Thank goodness I’m only here for the hair research. The hair-follicle culturing research falls under the category “Tissue Engineering” and below is a diagram displaying the Fukuda lab’s method.

University based research is always welcomed news, however at Follicle Thought we are focused on solutions. I thought it would be worthwhile to understand more clearly the current status of this technology. Here’s a Q&A with Junji Fukuda to let us know what’s next for his hair-follicle cloning research.

Q&A With Junji Fukuda PhD

Junji Fukuda PhD

FT: Hair follicle cloning is somewhat of a novel topic in the tissue engineering world. What led you and your lab to research Hair Follicle Germ formation?

Fukuda: AGA is common also in Japan and there are many people obsessed about hair loss. We read a nice paper demonstrating that HFG efficiently generated hairs when transplanted, https://www.nature.com/articles/ncomms1784 But, procedures used in this paper look very laborious and almost impossible to apply for human treatment because you need at least a few thousands of HFG for a single patient.

FT: What is the next step you and your colleagues are moving into now to further this hair follicle research?

Fukuda: The study was done with mouse cells. Our next step is to prove the same with human hair follicle derived cells. We now have a strong relationship with an AGA clinic and we can continuously get human hair follicles for our research every week.

(Editor’s note: Fukuda also mentioned here that his lab already has preliminary data using human cells to create HF germs)

FT: Finally, have you received interest from any companies to develop your technology for humans? 

Fukuda: Yes. Some companies have contacted me and we have already started some collaborations.

Thank you Junji, for sharing this information with Follicle Thought.

Commentary

It’s interesting to note that the research paper that Junji referenced in his response was lead by none other than Takashi Tsuji, a fan favorite among hair-research followers. Junji noted that the method used in Tsuji’s paper seemed labor intensive and near impossible to utilize for humans. It’s not to say that Tsuji hasn’t developed a superior method to his initial iteration by now, but the comparison puts into perspective what Junji Fukuda and his lab have accomplished. The Fukuda lab has developed a method to efficiently produce hair follicle germs at the scale we need them at, in the thousands. For the inevitable question of “when?”, it would expectedly be a couple years before we see Fukuda’s work used in humans. Follicle Thought will keep an eye on Fukuda Lab’s research and provide updates as they are available. 

81 Comments

  1. Arif on April 21, 2018 at 5:16 am

    When they are goung to start



  2. Coleen E Thomas on July 10, 2018 at 3:40 pm

    I am an African American female, with significant hair loss due to Alopecia. Is there a trial scheduled? What are the next steps for this research?



    • Follicle Thought on July 10, 2018 at 8:55 pm

      Hi Coleen, this research appears to be years away from a clinical trial. However there are many other therapies in human trials listed in the Articles section, as well as in the Ultimate Guide to Hair Regeneration article.



    • Follicle Thought on January 29, 2022 at 10:29 am

      Coleen, a reader was concerned about you knowing about the “big 3” treatment options of minox, finasteride, and ketoconazole. Please see a dermatologist.



  3. gregory battaglia on September 30, 2019 at 12:05 pm

    Am I wrong or would Fukada’s solution be way more cost-effective and even possibly closer to market launch for patients worldwide than anything from Repicel, Shiseido or other stem cell based regenerative biotechs looking to be anywhere near launch? https://www.newsweek.com/chemical-mcdonalds-fries-may-cure-male-baldness-study-say-799439

    How many more years will patients be strung along, this time with all of the hype about year 2020 being the end time for hair loss? And what are the chances that buying stock in Replicel, Shiseido and/or other big firms is not backfiring and actually delaying US launch? Read: Big Greed Factor ruins everything for most of us once again!

    How many of us can afford to leave our jobs, fly to Japan or China, buy the procedure for who knows how many thousands and stay there longer enough to insure that they don’t get hit with any bad surprises? Stem cell medicine is way too far along now for these speed bumps to be happening-and for procedures to be as expensive as they will likely be. Do readers and contributors here truly realize just how fast are we going nowhere? It seems pretty clear why. Hopefully, at least the Sandalore topical will actually launch next year-IF enough greed can be
    kept out of the mix.



  4. Follicle Thought on July 27, 2021 at 12:48 pm

    On March 13th, 2018 Junji Fukuda PhD told me that he hoped to start clinical trials in “5 years.”



    • User12 on June 18, 2022 at 3:16 am

      Hello since we are now 2022, wouldn’t that mean they should start trial in 1 or 2 years? Pls keep us updated. And can you share a screenshot of the replied email?



      • Follicle Thought on June 18, 2022 at 3:21 pm

        Thanks, I will share any updates from Dr. Junji as they become available, the last I heard within about 1.5 mos ago, he is working on his project which is now a formal company and therefore cannot share updates until he’s ready to make a notable announcement. I do not share screenshots of emails, I’ve been sharing validated industry news for over 6 years.



  5. Follicle Thought on January 28, 2022 at 12:05 pm

    Special thanks to reader buguan for the information.

    Also, for anyone wondering when the original article was published, simply look to the date of the first comment in the comment section!



  6. YoYo on January 28, 2022 at 12:48 pm

    This year has started off with a banger what do you think FT?



    • Follicle Thought on January 28, 2022 at 1:37 pm

      I agree it’s a bunch of good news and progress YoYo. Like in the previous Hope article, I asked what people thought of 2022 so far. Also, keep in mind there are potentially other companies like dNovo working behind the scenes who have yet to reveal themselves.



  7. skycheeseburger on January 28, 2022 at 1:30 pm

    Been a pretty good last few months.
    Saw there was a comment that from 2018 they hoped to get into clinical trials in 5 years.

    Hopefully 2022 is the year they start and we can have another hopeful solution to look forward to.

    Any chance of looking to get another interview Admin?



    • Follicle Thought on January 28, 2022 at 1:38 pm

      re another interview, I hope so skycheeseburger.



      • skycheeseburger on January 28, 2022 at 1:42 pm

        Thanks admin for all your work.



      • YoYo on January 28, 2022 at 1:52 pm

        You do so much for us FT thank you for all your hard work



        • Follicle Thought on January 28, 2022 at 6:28 pm

          Thank guys



          • J on January 28, 2022 at 8:22 pm

            Thanks for for the great work FT!

            I know it is to early to truly know this, but I was wandering about your thoughts on the cost for this treatment relative to some of the other companies out there currently.?

            It did sounds like this group had a bit more focus on ensuring their treatment would be more efficient and scalable aswell as less labor intensive than some of the other treatments such as Dr. Tsuji’s work.

            While I imagine financially it would still be unobtainable for most of us average baldies the first few years of its release, I’m wandering if those efficiencies may translate to this treatment starting cost being more affordable then the anticipated starting cost for the other researched techniques we’ve heard about. If this was case it could hopefully provide a bit more of an optimistic timeline for when it would be available at a price similar to hair transplants for you average person with hairloss.



            • Follicle Thought on January 29, 2022 at 10:47 am

              My only thought is that none of these companies have a realistic price set, and that talk a few years ago about Dr. Tsuji’s price was an isolated estimate. That being said, I imagine that if and when these treatments become available, they would utilize the same credit system that most hair transplant clinics offer now. Pay it off over time. Cost is not a big issue, that is basically certain to work itself out over time, getting the treatment into a clinic is most important.



  8. old bald 60 year old kid on January 28, 2022 at 8:55 pm

    folliclethought,

    just checking in to say … the end is near

    the days of shiny domes is coming to a close! very happy for the teenagers of today. They wont have to suffer like we did



    • YoYo on January 29, 2022 at 12:16 am

      How about us 26 year olds? Lol 😂



      • Arias on January 29, 2022 at 2:06 pm

        I’d say that we can hope for the best too 🙂 i mean, even a 10-year perspective isn’t that bad, at 36 you’re still young and with many good years ahead of you to enjoy your hair 😊



      • Alvaro on September 1, 2022 at 2:47 pm

        Hello Yoyo friend. Reading your comment and seeing that you are 26 years old I see myself reflected in you (I am also your age) and how often you visit this page with the same hope as me. Greetings guy!
        And friend FT, if you read my comment now, I’m writing in this section in case you still believe that Fukuda will carry out clinical trials this year, because honestly, after what those of us who read your page have been through, we don’t care if we wait for more years, but I think that This is one of the definitive and scientifically based solutions for baldness (even though unfortunately not results) but human trials are essential and hopefully in 2023 we will finally see the start of such a treatment.
        Thank you for your work for the page and for everyone!



        • Follicle Thought on September 2, 2022 at 11:51 am

          I do not believe Fukuda is that close to a clinical trial, no. Perhaps another year or two? I will look forward to my next update from him.



    • Gina on January 29, 2022 at 3:25 pm

      To the 60 years olds with a wealth of information on current treatments, has anyone had any issues with using dutasteride long term ( one year or more)? I read recently there might be a possibility of kidney stones, kidney damage or liver damage, but it is not definitive. Just wondering if anyone on this site might have used this drug over the long term and experienced any type of issues.

      Thanks in advance.



  9. Jason on January 28, 2022 at 10:57 pm

    So many companies reaching to the final solution , all of them are one step before clinical trails , we are indeed getting cloaer to the end.
    The one that make me happy the most is that once 1 company will make it , we would see tons of new biotech company trying to recreate the same idea.



  10. blave on January 29, 2022 at 5:29 am

    This year is full of good news so far. No matter what, with all these attempts, our scientitic knowledge of this topic will expand like crazy.



  11. woofy97 on January 30, 2022 at 1:25 am

    When people say 5 to 10 years away it’s like you’re being sentenced to 5 to 10 years in prison lol. 5 to 10 years is too long. We all just want to see hair cloning in clinics or at least in human trials already. It would have been nice if Stemson and these hair cloning companies started 20 years ago instead of in recent years. And I don’t even know what happened to Tsuji after the bankruptcy disaster the communication is dead, they get so close to trials, and then that shit happens such bs.



    • YoYo on January 30, 2022 at 3:46 am

      Hey Woofy it’s definitely possible that human trials for Stemson could potentially happen this year. In the conference Hamilton mentions human trials and about series B, so later this year or early next year we could see it happening. I’m guessing it won’t be in the US since Hamilton is talking about the quickest way to human trials, but still going through the tests in a suitable country, ie Australia, South Korea, UK etc.
      https://www.youtube.com/watch?v=vxWYMhD1VeE



      • blave on January 30, 2022 at 5:06 am

        No it’s not possible at all. In 2020 Alexey literally said “3-4 years probably more”. This puts it 2023-2024.



        • YoYo on January 30, 2022 at 6:09 am

          I’m not trying to be offensive but you’re not a scientist and are not there to know the exact advancements that have been made/making to confidently put your opinion out there. If human trials are to begin this year or next year, it would make your confidence seem folly.



        • Ben on January 30, 2022 at 7:59 am

          Yes, but Terskikh meant a market release, not trials!



          • Follicle Thought on January 30, 2022 at 10:40 am

            It’s unclear what Terskikh meant. I tend to think he meant getting into a trial around 2023-2024.



        • YoYo on January 30, 2022 at 8:45 am

          Yes but Terskikh should be entrusted with the science, not the market and potential release date. Asking him would be pointless essentially. Hamilton is the one assigned with all the marketability.



      • Woofy97 on January 31, 2022 at 1:11 am

        Thank you YoYo for sending me that link. And I hope they start this year 🤞🏻



  12. Alan J on January 30, 2022 at 2:57 am

    With reference to “old bald 60 year old kid” above, I’m also 60. I’ve been losing my hair since I was 23 (thankfully, very slowly). There isn’t a lot left. One thing that always annoys me is when people just advise shaving your head. Fine if you have a good shaped skull: not in my case. It’s just too cone like, which wasn’t a problem when hidden by enough hair. I had hoped we’d have a proper cure by now. That said, I really think things are looking very hopeful and this latest news just adds to that view; and it is just possible (just) that I will have my own hair back when I’m 70. In the meantime I am seriously considering some sort of hair system. I’m really not sure where to start e.g. is artificial hair really so much worse than real human hair (?); where do I go for a consultation (?); how can I get something as convincing as Bill Shatner has and not look like Michael Fabricant (an eccentric British Brexiter MP: Google him)? If anyone can point me to a site that can give me honest advice about where to start I’d be very grateful (am based in the UK, but am happy to travel to the rest of western Europe if need be). Many thanks.



    • Follicle Thought on January 30, 2022 at 10:41 am

      woofy typically has good information on hair systems. I’m not sure if he is up on European options.



  13. skycheeseburger on January 30, 2022 at 2:29 pm

    Hey Admin,

    Not sure if it’s been said but incase it’s helpful.

    It seems Technoderma has finished it’s 1st(?) Phase 1 trial.

    They essentially completed the single dose phase 1 and are starting the multi dose phase 1.

    News from Technoderma
    http://tkskin.com/en/index.php?a=shows&catid=16&id=18

    Single dose trial page
    https://clinicaltrials.gov/ct2/show/NCT04913519

    Seems this says 40 days left on recruitment here but not sure that’s accurate since the news says they started on the 5th this month.

    https://www.centerwatch.com/clinical-trials/listings/275081/a-phase-1-study-of-tdm-105795-topical-solution-in-male-subjects-with-androgenetic-alopecia-aga/?page=3&query=hair-loss&rnk=21



    • Shayak on January 31, 2022 at 12:20 am

      Hey skycheeseburger do you know the mechanism of action for technoderma product?



      • skycheeseburger on January 31, 2022 at 9:34 am

        Hi Shyak,

        I’m actually not sure they even mention it.

        Since it’s a multidose trial they’re doing i know it’ll probably be a daily topical.

        If it’s aiming to cause growth, prevent loss or both, I couldn’t say. Maybe admin knows more.

        PS just noticed the update page did cover the update. Sorry check the article page and just say last update at around may



  14. Marc on February 1, 2022 at 3:37 am

    Hi FT , thank you for this great news but may I ask you what’s the difference between Fukuda lab’s and han bio . is Han bio also working on hair cloning? But most of all what’s the difference between the two? Thank you for your time.



    • Follicle Thought on February 1, 2022 at 9:01 am

      Hi Marc, you’re welcome. Han Bio appears to be working on a dermal papilla cell injection therapy, similar to the company HairClone. Never heard of them working on hair cloning. Fukuda Lab seems to be working on creating engineered/multiplied hair follicles in vitro similar to what Stemson is working on.



      • Marc on February 3, 2022 at 2:07 am

        Cool thank you for responding if I may ask you how come you don’t have Dr junji Fukuda and Fukuda labs on your bracket in your ultimate guide pipeline? Does that mean me and everyone I know shouldn’t hold there breath for this? I hope that’s not a weird question to ask you, and if it is pardoned me.



        • Follicle Thought on February 3, 2022 at 9:08 am

          Marc, no problem on the question. Dr. Fukuda is not on the Guide yet because it’s very early. Even as he has started a new company it’s likely he is in very early days. However, when I receive new information that he is really moving on something he will go on the Guide. The Ultimate Guide is a subjective list of companies who I feel are the furthest along and closest to making significant milestones. I also made the Master List article to include every company, regardless of their progress. Junji is on the Master List and could be also moved onto the Ultimate Guide at any moment 😉



          • George on October 22, 2022 at 5:17 pm

            HLC2020 is stating that a human trial could start in 2023, any thoughts on that FL? That too early. I just don’t see why not given that a peer reviewed article of proof of concept has been published. Seem ahead of stemson who still seem to be trying to perfect the growth?



            • Follicle Thought on October 22, 2022 at 6:01 pm

              I do not expect a human trial to happen in 2023 George. I would mention that Stemson is definitely working on human cells by now. Fukuda could be working on human cells as well with this technique, but it does not seem perfected yet as the paper was based on mouse cells.



  15. Marc on February 5, 2022 at 5:30 pm

    Just one more question please, in a above comment you stated that in 2018 junji Fukuda told you in 5 years he Hope’s to start human trials which would be 2023 if my math is correct. Do you think that’s a real possibility and if so what time frame of a commercial release date realistically speaking do you think if even possible it’ll be available to us. And if I may add please excuse me but I feel its going to be the year 2026 and the estimated released date of 2029-2033 for stemsons therapeutic will change to 2035- 2038 keep in mind there’s a huge huge chance hair cloning will not work on human skin. May I please ask for your thoughts on this. Thank you for all your work. I would greatly appreciate your feed back so I can have closure and move on with my life, and not sit around hoping .
    because it’s literally mental torture I know that’s dramatic but I’ve been waiting for hair cloning since Dolly the sheep was cloned in 1997. thanks again for your valid information. : )



    • Follicle Thought on February 5, 2022 at 6:01 pm

      Marc I don’t recommend finding closure in your life based on the opinions of someone else. I would recommend you finding closure now by coming to terms with what your options are now and the certainty that the future is uncertain. I feel that is important for you to do.

      To your questions, absolutely it is a possibility that Fukuda could start a human trial in 2023 even if it is unlikely. I have a limited perspective of his progess, if I was in his lab I would know more. For Stemson, my opinion is that an estimated release date of 2029-2033 is fine for now. That’s a long time away. Within the next 2 years I will know more and can adjust the dates accordingly if need be. That’s why they can only be estimated.



  16. Follicle Thought on February 8, 2022 at 10:41 am

    I just heard from Junji Fukuda PhD again today. It seems that with the business now incorporated they will not be releasing information as freely. I will share any updates as they are available.



    • Marc on February 9, 2022 at 6:43 pm

      Hmmm interesting thank you for your work. So your saying there’s a Chance…..



  17. Jose on April 8, 2022 at 9:29 am

    Is transplanTed hair permanent or not?
    After transplantation do we need to take fina or minoxidil?did junji Fukuda form any human hair follicle germ or only mouse hair germ?when he will begin clinical trial?



    • Follicle Thought on April 8, 2022 at 10:15 am

      We would only have the answers to those questions when the treatment has been on the market for several years. Perhaps if it got to human trials, by then we would have a pretty good idea of it.



  18. John on October 23, 2022 at 3:19 pm

    Admin, who do you think will conclude human trials the soonest out of companies working on hair multiplication? Do you think Hanbio stands a chance?



    • greg on October 23, 2022 at 8:28 pm

      This is all such depressing crap!! It’s been 22 years since Cambridge University created a hair follicle in a petri dish. Since then-beyond basic if not essential practices including 5 to 10% minoxidil, massage, anti-androgens and nutritious but calorie restricted diets-there have been at least a half dozen scientifically viable approaches to hair follicle protection, life extension and regeneration. But not a single one of those “solutions”, no matter the level of success in actual human trials, has ever been launched in the North American market. And unless a dermatologist prescribed it, a compounding pharmacy could afford and access the ingredients and the patient’s insurer would cover most of the cost, it would likely be unaffordable for most people. Obviously, those like Shiseido, Replicel, Columbia and Manchester Universities and the rest get tax right offs, grant money and other compensations just by claiming to be doing “promising R & D” year after year, while countless balding millions are kept waiting for a day that will never come. How sick is all of this?



      • Follicle Thought on October 25, 2022 at 10:33 am

        Greg welcome to the comments, I don’t remember seeing you here previously. I just want to give you the heads-up that the FT comment section is intended to be a moderate environment which can be used to ask questions, ask for support, share ideas, and connect with other readers. Another intention is to be focused on solutions; i.e. how can we overcome the challenges which have impacted hair therapy development? Can we help get certain business people involved, etc? Overall, I would like the comments to be reasonably pleasant for visitors, who are most likely all facing some degree of challenge associated with their own hair. We understand the emotions, we just want to be proactive rather than to grind stones. Hope that makes sense.



        • Greg on October 25, 2022 at 3:34 pm

          Certainly in modern capitalist economies transactions and other activities intensify whenever both a strong and distinct demand for a particular item or service occurs. If we want to “help get certain business people involved”-especially those with large personal investment resources and/or with such associates-they would have to be convinced that a huge and sustained demand for a regenerative follicle cure is absolutely real. They would need access to online lists of tens of millions of real Americans-with names, addresses, jobs and healthcare insurers-who are screaming for a cure and who are able and willing to pay for at least some of the cost out of pocket. But make no mistake: Unless this demand can be proven not only to be enormous but actually quantified and individually validated-there will next to no chance to pressure insurance companies to cover even half of the cost. Otherwise, insurers can and certainly will simply fall back on the argument that hair loss is a cosmetic or “quality of life” issue and for which coverage is is justifiable. The question is do groups like folliclethought.com have the resources to advertise, attract and convince hair loss sufferers to share their contact info and personal health insurer-and to amass and circulate the lists of said millions? YOUTUBE might be a great tool for this! If enough videos could be produced, using different actors, investors, patients, doctors and researchers all inviting viewers to sign up here and at other sister websites, the numbers could then get big enough for a petition to get an insurance reform bill put before Congress. If such a bill becomes part of health care insurance regulations investors will see that sustained funding is available to pay for a proven cure offering robust results within months in most cases. Needless to say, any insurable solution would certainly have to be WAY more cost effective than something like PRP or even laser therapy, if it’s to get considered by a congressional and then approved by a regulatory committee. So unless some angelic R & D team invents and gives away the perfect cure to everyone, this will likely be the only path to success.



          • Follicle Thought on October 25, 2022 at 5:13 pm

            That was a thoughtful post Greg, thank you. I believe that many pharma are aware that people are willing to pay out of pocket for their hair, which is certainly the truth. I think it would be great if we could get insurance on board, and this is a good initiative/idea which deserves further thought – a useful strategy. In parallel, just getting business folks to fund/invest into the actual R&D is optimal because we still need new treatments/cures whether or not they are out of pocket or covered by insurance.

            As an example, Amplifica just raised $11M from American investors who are aware that these potential treatments will not be covered by insurance, but were willing to invest because any new effective hair solution is more than lucrative itself.



    • Follicle Thought on October 24, 2022 at 3:45 pm

      Hanbio potentially stands a chance to conclude a trial first, but I don’t have them pegged as the best technology out. I like Stemson, Epibiotech, and Tricho Seeds.



      • Soul on October 25, 2022 at 3:09 pm

        hello admin. Thanks for everything!! I’m a bit off lately for work reasons. but I’m surprised “Tricho Seed” I never read about this. thanks again admin



  19. Gurvinder on October 24, 2022 at 1:59 pm

    Amplifica has completed series A funding.



  20. Hope on October 24, 2022 at 7:23 pm

    11.8 million is very impressive. That means the technology behind it shows promise. Especially when you consider that the company has focused on hair loss. Think they will hire a lot of employees in the next few months. It’s nice to now have three promising companies in Stemson and Hope



    • George on October 25, 2022 at 2:54 pm

      To me it seems the front runners are Stemson, Epibiotech, Fukudua regarding cloning hair. All three seem very promising and I feel we should see clinical trials in the next 2-3 years? I honestly feel in the next 10 years one of these companies will have a real solution. What do you guys think?

      Hope and Amplifca seem promising with stimulating new hair growth but not cloning.

      The wild card is dunovo hair too



  21. YoYo on October 26, 2022 at 4:50 am

    New Stemson interview for those who are interested https://www.scienceboard.net/index.aspx?sec=cgt&sub=def&pag=dis&itemId=4909



    • Alvaro on October 26, 2022 at 8:42 am

      Hello Yoyo, do you know if this video you have shared is available with Spanish subtitles? Regarding the work of Fukuda and his team, I believe that the line of research they are following corresponds to the same as Stemson. In their work: https://www.science.org/doi/10.1126/sciadv.add4603, they mention that the obstacle they have for not testing their work with human cells but with mouse cells is that for the creation of a de novo folicloid in vitro they would need to use neonatal or fetal stem cells, which is unethical… That is why the test for hair organoids will have to be carried out with adult pluripotent stem cells (ipsc), just like Stemson. These two companies, in my opinion, have sufficient scientific bases to bring the cure to the market… hopefully as soon as possible



      • YoYo on October 26, 2022 at 10:58 am

        I’m not 100% sure what Fukuda’s method is but from my understanding they are not using stem cells but they are creating hair follicles in a matrix. Stemson IS using iPSC’s by taking blood/skin and converting those cells into hair follicles and then transplanting those new hair follicles in the balding areas. Regarding the video Geoff was basically stating that he believes Stemson is around 2 years away from testing their product in clinical trials. (Hopefully they pick another country for their trials excluding USA). And that it’s a one time procedure, unless you have other areas that are balding so you’d go again to get the procedure done. I don’t think we’ll hear anything regarding clinical trials from Stemson until 2024 I reckon. I read somewhere that Fukuda is planning clinical trials sometime next year the good thing about Japan is that their clinical trials aren’t as long as the US. Hope that helped.



        • Alvaro on October 26, 2022 at 12:12 pm

          Thanks for the explanation about the video, Yoyo. What I was referring to is that probably the procedure by which both researchers have demonstrated the creation of a follicle germ is the same, through the IPSC. Remember that these induced adult stem cells have the ability to transform into any type of cell in the body, in the case of hair: epithelial and mesenchymal to together form the follicle germ de novo. It must be remembered that in the Fukuda method, the implantation will be of the follicle germs, not of fully developed follicles, and the experiment of creating the mouse follicle in vitro is to observe the effect of drugs, identify genes, and other aspects, but no for their implantación.



  22. Hope on October 26, 2022 at 11:38 am

    he did not say that the studies are 2 years away, but that they will take at least a few more years. Stop always twisting the statements and giving people unnecessary hope. Studies probably not before 2025



    • YoYo on October 26, 2022 at 12:07 pm

      I really don’t like to reply to people such as yourself Hope but frankly you irritate me. The context of the video is about how long the studies are away from a clinical setting, listen from 2:00 to 2:10. A couple of years before we feel we are ready, do you not understand what a couple mean roughly? It’s 2 years give or take you literally added one more year. What difference is there with 2 or 3 years. And how am I ALWAYS giving unnecessary hope, I just stated my opinion on how long I think it’ll take till this reaches clinical trials. You stated one more year than me. Please do not message or reply to me as I personally view you as a parasite to society. Have a great day.



  23. George on October 27, 2022 at 12:41 am

    Thanks for posting the interview YoYo. Stemson seems hopeful and I feel in the next two years well know our answer if this is it. If so we’ll have a real cure in the next 5-10 years. I know that statement is over said but we’ll know soon enough which is exciting



    • YoYo on October 27, 2022 at 2:01 am

      No worries George, Stemson, SCUBE3, Epibiotech, Fukuda, Han Bio there’s many things in the future to be excited for. Hopefully we get some positive news finally lol.



  24. Tom on October 27, 2022 at 3:59 pm

    Hi admin, I have a question, is scube3 going to be ultimate hairloss cure if it revives dormant hair? Is it possible to revive all hairs on full bald head?



    • Alvaro on October 28, 2022 at 10:03 am

      Tom friend, according to recent studies demonstrated thanks to new technologies (microscopes, genetic and molecular markers…) the mechanism of alopecia is known (androgenetic alopecia, as its name suggests, comes from your genetics), knows how these genes affect the stem cells of the dermal papilla of the hair follicle and their interactions through DHT. SCUBE 3 is a key molecule in the interaction between these stem cells which gives the order to remain active or inactive, so if these stem cells have been inactive for a long time (a bald head), these cells will have escaped from the organism being It is impossible to activate them again. Kintor Pharmateutical’s medication is an antiandrogen, that is, it blocks the receptors found in the hair follicle to prevent the effect of DHT. With this I want to tell you that a solution in the form of medication for advanced baldness is materially impossible (these solutions are valid for those who have undergone a hair transplant, as is my case, or cases in which baldness is detected in early stages). That’s why I always tell FollicleThought that my wish is always a solution like Fukuda’s or Stemson’s, since I wouldn’t want to take drugs all my life either. I hope I’ve helped (:



      • YoYo on October 28, 2022 at 10:58 am

        Hey Alvaro I think that they had stated that hair follicles that have been inactivated are definitely able to be reactivated via SCUBE3, you still have the follicles there it’s just that they are dormant. SCUBE3 will be like “restarting the factory” thus having that hair follicle active once again. You can read more about it from here if you don’t believe me lol. https://www.today.com/health/new-study-points-possible-cure-baldness-rcna40980



  25. Woofy97 on October 28, 2022 at 12:25 pm

    Is Dr Rassman’s $11.8 million funding for the hairy mole treatment or for Scube3? Or both?



    • Follicle Thought on October 28, 2022 at 1:02 pm

      It could potentially be for Scube3 down the road Woofy, but for now the $11M is for Amplifica’s 2 compounds 303 and 506, which I don’t know exactly what they are but they are not Scube3 to be sure.



  26. Gurvinder on October 28, 2022 at 11:08 pm

    Han bio was about to start clinical trials in first half of 2022.but it’s the end of the year . Have they gone silent too.



  27. Danny on October 29, 2022 at 6:02 am

    Anyone knows something about the launch of Triple Hair or Follica ?

    What’s your thoughts on them guys?

    Thanks



  28. Devit on October 29, 2022 at 8:50 pm


    • Follicle Thought on October 30, 2022 at 8:22 am

      Anyone here using kx-826 or following someone trustworthy? What’s the initial feedback? In general I don’t advise people to try this approach, but I know people are doing it anyways. I had a longtime reader reach out to ask me about the word on how people are faring.



  29. gipsy on October 31, 2022 at 6:05 am

    hello Folliclethought, I’m sorry for my last time comment which you took the wrong way. it wasn’t against you but the hair loss industry , your site and information are cool.

    about Kintor, a lot of people report side effects on Reddit and hairlosstalk ( brain fog, low libido, testicle pain etc), and I haven’t read any success story up to now



  30. Bob on November 7, 2022 at 6:46 pm

    So they’re going to clone hair follices by using our own stem cells? Sounds really neat but how much will it freaking cost? He’d probably charge like $50,000 mininum :(. I won’t be able to afford it. The demand will be so high and supply low since they’re the only providers (they’ll probably have a patent, too), the waiting list will probably be over a year.

    ;_;



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