Histogen Announces HSC Trial Plans In 2020

Histogen Doses First Patient In 1B/2A Trial – Update 6/2/20

Histogen has wasted no time in getting their latest trial of HST-001 (HSC) underway. On June 1, 2020, the company sent out a press release to announce the first male patient has been dosed in their latest trial of HSC. Positive developments seem to be pouring in for Histogen lately and they are making good on their promises, we love to see it in 2020.

Here are the important items from Histogen’s latest HSC trial:

  • Trial will include 36 male subjects
  • Safety as well as efficacy will be measured
  • This is the first trial in which Histogen will observe the effect of 3 doses which will be given at weeks 0, 6, and 12. Each dose will include 21 injections across the scalp.
  • Results are expected in Q4 2020

Besides the good news of the trial starting, Histogen became a publicly traded company on Nasdaq last week, its shares are being traded under the ticker symbol (HSTO). Let’s go Histogen.

IND Approved – Update 5/19/20

On May 11, 2020 Histogen announced that the FDA has approved its amended Investigational New Drug Application ( a permit to conduct a clinical trial) for HST 001 also known as HSC.

With the IND Histogen plans to initiate a phase 1b/2a trial of HSC in the treatment of male pattern baldness during Q2 2020. The news release also mentions that “start-up activities” for the trial have already begun including study site preparation and subject screening. Histogen’s CEO Richard Pascoe had this to say about the recent news:

The FDA acceptance of our IND application represents an important milestone for Histogen and HST 001 and keeps us on schedule to commence our clinical trial in androgenic alopecia as planned in June 2020,” 

This is impressive and unexpected news as June 2020 is next month. Could the most fabled hair growth treatment of all time finally make an emergence to the center stage of the hair restoration industry? It’s definitely put-up or shut-up time for Histogen, but I think there are still a lot of people in the world holding onto hope for a happy ending in the HSC story. Apparently, we’ll find out shortly…

(Thanks to Fuji of HLC Japan)

Original Article

With a little luck, we should be seeing an important clinical trial of the fabled Hair Stimulating Complex before Fall 2020.

In a recent news release through the company’s website, Histogen announced they have filed an amendment of their Investigational New Drug application for their HSC program. Within the news release, Histogen mentions that they are targeting a phase 1b/2a trial of HSC in male pattern hair loss during the second quarter of 2020. This is an ambitious date, especially among the coronavirus restrictions that most of the US is dealing with, but possible. Some US states have begun to reopen recently.

Factoring in a slight delay, we can expect an HSC trial to begin somewhere in the range of June/July 2020.

Why Things Should Be Different This Time..

Most people are privy to the fact that Histogen has not been the most expeditious company when it comes to bringing a product to market, however, there are some reasons to believe that the outcome could be different for Histogen this time around. Here are some points to consider:

  • The #1 Factor. Allergan is no longer putting up a big roadblock for HSC (by suing Histogen) and is actually an ally this time. Allergan now sells Histogen’s cell conditioned media in their Skinmedica skincare line.
  • Conatus Money. Becoming a publicly traded company after merging with Conatus Pharma will benefit Histogen in the financial category. It gives them the opportunity to raise funds on the stock market instead of being relegated to angel investors. A lack of finances to begin clinical trials has stifled many companies in the alopecia industry over the last decade, Histogen being one of them.
  • Partnering Is Imminent. It is virtually guaranteed that if HSC does well in its upcoming trial for male pattern baldness it will immediately be licensed to a major pharmaceutical company (very likely Allergan) and then expedited through the clinical trial process. Larger companies know how to get therapies through trials quickly and can do a much more efficient job than smaller biotechs.

Wouldn’t it be nice if we finally get the injectable therapy that delivers finasteride-like regrowth without the side effects and daily application? And for those that think 2025 is too long to wait for HSC, you may not have examined what other guaranteed new options you will have by 2025. It’s still one of the most interesting treatments in the industry – it just desperately needs to enter a clinical trial in 2020.

181 Comments

  1. Baumer on April 23, 2020 at 7:19 pm

    We’ve seen (or trust) that the treatment works. If they really do get this in the pipline we may just invest hope once more into HSC.



    • Matthew on April 23, 2020 at 7:46 pm

      Yes, hopefully 2020 will be for Histogen what 2004 was for the Red Sox!



      • Yoda on April 23, 2020 at 7:52 pm

        I thought you were going to say what 2004 was for Histogen! 😉 Maybe they haven’t been around quite that long but pretty close. I used to get excited about these guys, now not so much. However, I haven’t been one to pile on either. Let’s hope they get their act together and live up to the potential/hype.



        • Matthew on April 23, 2020 at 8:00 pm

          I hear you, Yoda. I’ve been a frustrated rider on the Histogen roller coaster for nearly a decade.



  2. Matthew on April 23, 2020 at 7:34 pm

    Wouldn’t it be nice, indeed. And queue The Beach Boys… ?



  3. C on April 23, 2020 at 7:40 pm

    If I am not mistaken, I read somewhere Histogen HSC failed in its trials in Mexico some time ago. This seems like Replicel RCH-01 all over again…if you catch my drift!



    • Yoda on April 23, 2020 at 7:53 pm

      I don’t believe they failed clinically in Mexico, the deal never came together.



      • Follicle Thought on April 23, 2020 at 8:07 pm

        Yes Yoda, you are correct.



    • Follicle Thought on April 23, 2020 at 8:06 pm

      Inaccurate actually, the trial never got going in Mexico.



  4. Russell Dee on April 23, 2020 at 8:39 pm

    I think Histogen’s before & after photographs aren’t very good and I think they combed hair differently and used different angles in the after pics to make them look like there was more regrowth than there actually was.



    • Follicle Thought on April 23, 2020 at 9:48 pm

      Photos were never phenomenal, but it showed pretty reliable regrowth from an injectable, which is the worthwhile part. Also, no one really knows what kind of efficacy it can produce over a 12 month period with maybe 4 sets of injections.



      • Russell Dee on April 24, 2020 at 2:28 am

        Yea there are things people don’t know, such as multiple sets of injections but their before and after photos did not look good. There were different angles, lighting, and hair styles between before and after pics.



        • Follicle Thought on April 24, 2020 at 11:11 am

          How many pics were like that? Please reference with links. There’s only one I can think of that had a different combing effect but majority of people still felt that the guy objectively had more hair in the after photo. There have been several images of women regrowing clear amounts of hair. Take a look at my Histogen Review articles, they include several photos that look good and consistent lighting etc.



    • Yoda on April 23, 2020 at 10:32 pm

      Here we go…the great comb over conspiracy!



      • Russell Dee on April 24, 2020 at 2:31 am

        “The great combover conspiracy” What a laugh! Lots of people are saying the same thing I’m saying. And lots of people also say that some companies do use scammy pics to make their products look better than they are.

        And in the end if it turns out there isn’t good efficacy what will you say then? Will you admit that you’re foolish?



        • Follicle Thought on April 24, 2020 at 1:28 pm

          Russell, I always appreciate your support, let’s try to keep things pleasant here when possible.

          A question I’d pose is, if HSC was no good, why would Allergan/Skinmedica bother to block it’s entry to market and sue Histogen?



          • Russell Dee on April 24, 2020 at 3:07 pm

            Follicle Thought, Yoda started the problem with his nasty post basically calling me a conspiracy theorist. He ragged on me so I ragged on him. His post ridiculed people who generally believe that some companies use scammy before-and-after photos and almost all of us believe that some companies use scammy before-and-after photos. And his post ragged on people who think Histogen used scammy photos and lots of people believe that.

            I think you’re getting after me in this disagreement because you’re in the tank for Histogen corner because my post wasn’t unreasonable or excessively unpleasant. I merely got snotty with a poster who got snotty with me first. You are overly protective when it comes to Yoga and Histogen. Perhaps you have invested in Histogen??????



            • Follicle Thought on April 24, 2020 at 7:42 pm

              I’ve never been a big fan of yoga, I like hiking and/or calistenics better. By the way, relax dude, I didn’t say anything harsh to you and my intention was not to single you out, just asked to try to keep things pleasant.



          • Yoda on April 24, 2020 at 5:51 pm

            Admin, in respect to you I will refrain from directly ripping Russell and his “logic” a new one! 🙂 In response to your question about the lawsuit I’m certain there’s a great conspiracy to be had there too. You know ” lots of people are saying”…



          • Yoda on April 25, 2020 at 4:16 pm

            Yoda loves yoga! 🙂 You should try it Russ, helps one to find their center and be more chill.



  5. Matt on April 23, 2020 at 8:59 pm

    I wonder where the trial is going to be. It looks like they have already partnered with haupont sciences for their hsc product according to website pipeline



    • Follicle Thought on April 23, 2020 at 9:51 pm

      Trial will likely be in San Diego area.



      • Yoda on April 23, 2020 at 10:34 pm

        If it’s in San Diego Yoda’s in! Unless all the other crap I pour on my head and put in my body to keep my hair are disqualifiers. 🙁



        • Follicle Thought on April 23, 2020 at 11:11 pm

          Haha, they’re definitely disqualifiers, but maybe you can get a pass cuz of your experience in the game haha.



          • Yoda on April 24, 2020 at 6:08 pm

            Are you sayin I’m old Admin? That in itself might be disqualifying!



  6. nanni86 on April 23, 2020 at 9:57 pm

    thanks a lot admin for everything … so according to the ARTICLE it can be released before 2025



  7. Chris on April 23, 2020 at 10:01 pm

    Do we know if they’ve made any modifications or improvements to the actual product? Or is this the same formula they’ve been attempting this whole time?



    • Russell Dee on April 24, 2020 at 2:32 am

      I don’t know. I just know their previous pics with their original formulation looked dubious.



      • Yoda on April 24, 2020 at 6:07 pm

        As mentioned, I’m from San Diego where Histogen is based. Dr. Gail Naughton has a good reputation in the local community, I imagine in the Biotech community as well. Unless you’re Bernie Madoff, raising money from investors is highly regulated. Scam pics would open themselves up to all kinds of legal jeopardy, both the business and personally. So if you think Histogen is a criminal enterprise I’d contact the proper authorities for a thorough investigation.



    • Follicle Thought on April 24, 2020 at 11:08 am

      It appears HSC has been altered over the course of its history, we don’t know exactly which iteration is being tested this next time. My guess is its similar to the original HSC with possible slight improvement or change in composition.



  8. Andreas Lutz on April 24, 2020 at 6:58 am

    The most important aspect (in my opinion) concerning the reasons why it may be different this time:
    Histogen has a very good CEO (Richard Pascoe) since January 2019. Since Richard is the CEO Histigen has made enormous progress in many aspects, e.g. the ongoing merger with Conatus Pharmaceuticals, the Investigational New Drug Application Amendment for HST 001 for hair loss and more recently an Investigational Device Exemption (IDE) application with the FDA for the initiation of a Phase 1 clinical trial of HST 002 for the treatment of facial folds and wrinkles.Additionally they are planning the submission of an IND to study HST 003 in the regeneration of focal cartilage lesions in the knee, which will probably be in Q3 2020. This is in fact impressive progress since January 2019.

    It has always been my opinion, that Dr. Gail Naughton is a brilliant researcher, but a terrible business woman. So the change in the CEO position has finally solved the problems concerning the business development of Histogen.

    So I am very optimistic now for much faster progress than in the past! And the HSC approach is still one of my favourite projects!!!



    • Follicle Thought on April 24, 2020 at 11:12 am

      Thanks for the contribution Andreas.



    • Yoda on April 24, 2020 at 6:09 pm

      Astute observations Andreas!



  9. Nils on April 24, 2020 at 9:23 am

    Hey Admin,

    in your Pipeline you changed the release date from J.Hewitt (in Japan) to 2024
    Do you have any Updates ?
    Do you really think that it will need so much time ?

    Tought in the next 1-2 years



    • Follicle Thought on April 24, 2020 at 11:15 am

      Nils, like I’ve been mentioning in previous comments, it’s just a conservative date estimate, it could come out before 2024, it could come out after 2024.

      Most companies and consumers will project a date for the best possible release date of a product and we’ve seen that this is not always the case, right? So, I just put up a date with a little more cushion for the unexpected. I expect the projected date will change by the end of this year depending on the progress that J. Hewitt makes. 🙂



      • Nils on April 24, 2020 at 1:27 pm

        Understand
        Nice mindset!



  10. D1 on April 24, 2020 at 10:58 am

    what happened to the LA company with the cosmetic? @FollicleThought



    • Follicle Thought on April 24, 2020 at 11:15 am

      I haven’t heard anything new from them yet, but I hope there is an update by this summer.



      • D1 on April 24, 2020 at 5:29 pm

        @FollicleThought keep on them!



  11. Matt on April 24, 2020 at 1:47 pm

    It has to be a new version of HSC otherwise they wouldn’t be going back to phase 1..?



    • Follicle Thought on April 24, 2020 at 7:51 pm

      We’d need more info to answer,they didn’t go back to exactly square one since the new trial is a phase 1b/2a, but it seems they should have been further along than that by now.



  12. Vienna on April 25, 2020 at 6:35 am

    i can see why people are sceptical about histogen after so many years.

    on the other hand and considering that clinical trials are costly, it just shows that they truly believe in their product and are determined to bring it to the market.

    let‘s hope for the best and thanks for the news, admin!



    • Greg on April 25, 2020 at 6:57 am

      This is off topic but should you take finasteride every day to not fluctuate DHT levels or can you take it every other day?



      • Follicle Thought on April 26, 2020 at 1:16 am

        I’m not a finasteride expert as I have no personal experience with it. I know a lot of members here have been using fin for years.



    • Follicle Thought on April 26, 2020 at 1:20 am

      Thank you Vienna. I can understand the skepticism I suppose, though, sometimes it seems like people don’t take into account that Histogen caught completely shafted for the first 5-6 years of its inception due to costly legal battles with Skinmedica. If that had not happened I would probably feel the same way. But I try to cut them some slack and know that things have not been ideal since that happened.

      I’ve just been thinking of what kind of results Histogen + the Triple Hair formula would produce. The guy with gray hair almost fully got his crown back in the recent results photos, HSC would probably super charge those topical results.



  13. Lillith Mackenzie on April 25, 2020 at 1:24 pm

    I’ve been following these “Breakthroughs” since the early part of this century. And I remember literally dozens of companies: “Coming as early as 2002…2005…2008…2010…2015…get the picture? many had some excellent products that seemed to work, but vanished from the market, usually after being bought out or shut down by big pharma, (which is why you can’t get the topicals containing finasteride, ultra high dose minoxidol, and proprietary ingredients! And I know, I used them and they WORKED!) or by the gigantic hair replacement system companies.

    So now, it’s “By 2025?” anyone else out there who’s going to long since be completely bald by then?



    • Follicle Thought on April 26, 2020 at 1:15 am

      There’s also the potential of more potent regenerative therapies, aka hair cloning to be out or close by 2025. Organ Technologies, TissUse, Stemson are in the game for that.



    • Russell Dee on April 26, 2020 at 4:30 am

      You are absolutely right and other research groups will bring different treatments to market by then. I really think that histogen would be a fools errand at this point. Plus, I stand by my statements that the Histogen before and after pics are dubious.



      • Follicle Thought on April 26, 2020 at 11:13 am

        I’m still interested in seeing the pictures you’re referring to.



        • Russell Dee on April 26, 2020 at 4:02 pm

          It’s too much trouble for me to go hunting for them. I have a life outside of hair loss.



          • Follicle Thought on April 26, 2020 at 7:32 pm

            Okey doke



  14. Johny on April 26, 2020 at 3:08 pm

    It’s taking them too long. They just keep on throwing anything they can at this. I bet their current protocol does not even remotely resembles the one they worked on 12 years ago.



  15. Russell Dee on April 26, 2020 at 7:42 pm

    Follicle Thought, it’s supposed to be Okey Dokey, not Okie Doke.

    And I didn’t mean it sarcastically. I meant it factually. I really don’t have time to go searching for specific study pics. Those pics are out there and a lot of people have seen them and a good percentage of the people who have seen them say the same thing I’m saying – that the pics look dubious.

    Now if they’ve changed the formula then maybe the results are better but I’m not going to count on Histogen because there’s just been so much delay and cancelation of studies that I’ve really gotten bored of them and I don’t have a lot of faith in them anymore. I used to when it first started being discussed numerous years ago but with all of the delays and study cancellations I’ve lost interest, at least for now. If they can get on track and show some good results that don’t look suspicious then of course I’ll be praising them. But it’s not time to be praising them yet.

    That having been said I do believe that hair loss sites should keep track of them because when all is said and done it might end up working.



    • Follicle Thought on April 27, 2020 at 10:57 am

      It’s actually supposed to be okey doke and I didn’t write okie doke the first time, but no big deal in any event.

      Though, for the record, it does not hold too much weight to keep stating that pics look dubious and not being able to produce any evidence. In any event, I hope there is good news for you and all this year regarding hair growth treatments, especially from Histogen among others. Have a good day man.



  16. Yoda on April 26, 2020 at 9:05 pm

    Russell, I think pics are like art. Two people can look at them and have an entirely different interpretation. In regards to Histogen, I might see a heck of a lot of regrowth from a company that has esteemed researchers behind it. On the other hand, you might see a comb over, toppick, lighting issues, etc. By “conspiracy theory” I simply meant I’ve read this on multiple occasions, on internet forums and I find it hard to believe. You seem like a good guy, like all of us you want results. Unfortunately it’s just not coming as quick as any of us would hope. Doesn’t mean it won’t or Histogen will be successful or will not be. Yoda was once a young man loosing his hair, it’s very traumatic. I was proactive and have kept most of my hair since I started to loose at 17, now I’m 57. We are living in unprecedented times, stay positive about treatments to come, yourself and life in general. And yes, Yoda still recommends Yoga to all for sure! 🙂



    • Chris on April 27, 2020 at 9:19 am

      Yoda, how were you able to save your hair. I’m too 19 and thinning hair. Please any suggestions or advice ?



      • Yoda on April 27, 2020 at 5:27 pm

        Chris, are you currently on any treatments? What Yoda is using at 57 is different than what used to work for Yoda in his early 20’s. It’s been an evolution, unfortunately of “stronger” treatments for the past 35 years. At your age you should consider 5% minoxidil and see a doc about finasteride/propecia. In a nutshell, these are what has saved Yoda’s bacon, although with different additives and strengths over the ensuing years. No appreciable sides to speak of, which is what the data shows is the more common experience. Hope that helps, good luck young man.



  17. Hadex on April 27, 2020 at 3:49 am

    Sounds like an opportunity to raise funding as usual.



  18. Jonathan Weaver on April 27, 2020 at 11:43 am

    There is no way we get this in 2025. This is only a phase 1b/2a. Next, it will be phase 2b in 2021/2022. A phase 3 should start at 2024 and end in 2026. Commercial release probably 2027/2028. That’s how long clinical trials are unfortunately.

    The best way to go is PTD-DBM polypeptide with dermarolling, and Samumed in 2022.



    • matt on April 27, 2020 at 1:29 pm

      Given their HSC product has a Chinese partner I bet phase 2b is in Asia with market approval after that so 2024-25



    • Follicle Thought on April 27, 2020 at 2:48 pm

      Jonathan, it all depends on how quickly and efficiently they can get the trials done. Phase 2a could be done by the end of the year and phase 2b could be done by the end of 2021. Allergan used to steamroll bimatorpost through scalp trials, it could do the same for HSC.



  19. D1 on April 27, 2020 at 12:37 pm

    @FollicleThought its 18 months since Samumed started their trial? Will they not report anything soon?



    • Follicle Thought on April 27, 2020 at 8:16 pm

      I don’t think they will report anything until the trial is completed and the data has been unblinded and analyzed.



  20. Paul on April 27, 2020 at 2:32 pm

    Hello there.

    I’m 39. Diffuse thinning over the top. So far, I’ve been able to hide my thinning with strategic styling and concealers. I am contemplating a buzzcut.

    So, has anyone with diffuse thinning tried a buzzcut? If so, do you have before and after pictures that you are willing to share? Obviously, I don’t how a buzzcut will look until I actually do it, but I’m trying to get a rough idea of what it might look like.

    Thanks for all the work you do, admin! Appreciated.



    • Follicle Thought on April 27, 2020 at 2:51 pm

      Thank you for the gratitude, Paul, and thanks for being part of the community here.



  21. LouiSarkozy on April 27, 2020 at 6:15 pm

    sry to bother you with that admin but do you still think sammumed is on track to releae their products q2 2021 in turkey? And do you have any new from follicum. Thanks



    • Follicle Thought on April 27, 2020 at 8:18 pm

      I think Samumed is on track to release a product around 2022/23. Follicum is temporarily paused on their new topical phase 2 trial and will be hopefully be recommencing within the next 2 months depending on how Europe is dealing with the coronavirus stuff.



  22. Paul on April 28, 2020 at 12:49 pm

    Anyone tried Proxiphen?



  23. Bobby on April 28, 2020 at 1:32 pm

    Not going to lie. I have nothing against HSC; but their first trial was administered and photos were taken by Dr Craig Zeiring.

    The guy who was sued for fraudulently using two different people in before and after pics to pump his transplant clinic.

    So forgive me if I’m skeptical of a company that works known frauds. I mentioned this years ago when HSC was still “hot”.

    Even though as an investor I would consider the CEO and management brain dead for not researching Zeiring properly before working with him knowing future investors who are not brain dead would to their DD on Zeiring; I still hope these goofs prevail.

    No sweat off my back if they don’t succeed; I’ve gotten my maintenance under control.

    As for why Allergan switched up its simple. Why would they hinder the process of something they know is irrelevant?

    And if it just so happens to workout in the end they lose no money and get to be the ones to take the product to market.



    • Russell Dee on April 28, 2020 at 1:57 pm

      I’m not real interested in Histogen either Bobby. If they produce irrefutable promising results I’ll pay attention but unless that happens I’m tuning them out.



    • Follicle Thought on April 28, 2020 at 8:50 pm

      Everyone has the right to be sketpical or not, no big deal and it won’t affect the scientific outcome of HSC. Ziering may not have been an ideal choice to investigate a trial with, for sure, but his previous marketing ethics don’t much affect his ability to inject a growth factor serum. Histogen does have data outside of Ziering. One of which is this phototrichogram which was overseen by Dr. Rolf Hoffman, one of my favorite data from Histogen: https://media.xconomy.com/wordpress/wp-content/images/2010/04/06210436/Histogen-hair.jpg

      Allergan uses Histogen’s CCM in their Skinmedica line because their own CCM was inferior, so safe to say they think highly of it. I’m not saying HSC is a sure thing, but I’m rooting for them and I find that more enjoyable than being a skeptic. I’m Ok with what HSC’s outcome turns out to be.



  24. Stephan on April 28, 2020 at 2:38 pm

    Wow, really interestung things beeing said! So and so i have a better feeling about the stem cells treatments in general…



  25. John on April 28, 2020 at 5:51 pm

    Admin, I always wonder why we focus on unapproved and exotic new drugs which need years and years from one disappointment to the next and already approved drugs which already are available are not seen.

    What do you think about this Story and Research from UCLA?

    These drugs are known and approved and can be used topically against AGA:

    topical Metformin
    topical α-ketoglutarate (α-KG)
    topical Rapamycin

    “Stimulation of Hair Growth by Small Molecules that Activate Autophagy”

    https://www.sciencedirect.com/science/article/pii/S2211124719306990



    • Follicle Thought on April 28, 2020 at 8:54 pm

      It’s interesting John and I’ve done an article on it, it just needs a human trial to show what it can really do! I hope they can do one for it.



    • Rap on April 29, 2020 at 4:02 am

      Hey John if you really want to be a pioneer you can always apply this to a small area (size of a dime) and let us know how it turns out.

      I’d look into all side effects before doing so and taking it into your own hands. After all Rapmycin is an immune system suppressor.

      https://www.wedgewoodpharmacy.com/blog/posts/sirolimus-rapamycin-topical.html

      But hey; feel free to lead the way lol. I’d
      Love to know how it works out…

      As for metformin it actually has a lot of negatives Dr Sinclair fails to mention in his promotion of the drug. I was literally a Sinclair groupie until I started doing a lot of my own research into anti aging. Not saying he is wrong; but here are many exciting pathways. NAD+, PDGE Blockers etc. There are safer ways to get the effects of Metformin without the undesired side effects including a 60% drop in testosterone production.

      The goal is to have both hair and testicles.



      • Follicle Thought on April 29, 2020 at 10:54 am

        A lot of people already take rapamycin orally for anti-aging effects which is a more risky route than topically. I don’t know how common adverse events are but so far it seems within the realm of “reasonably safe.”



  26. John on April 29, 2020 at 3:47 am

    Thanks Admin, its just so frustrating to see this Research was released a year ago with available drugs and we see nothing since then and it probably will need another several years. This whole hair loss research and industry is just so ridiculous.

    I more and more have the feeling that hair loss Industry will fail totally in the end and we will focus on Antiaging Industry …

    https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/



    • Follicle Thought on April 29, 2020 at 10:52 am

      You bring up a great point though, John. There are likely multiple drugs which could be used topically to grow hair and it seems likely that a few of them could produce results similar to minoxidil (possibly better?) But in order to truly find out we would need to see a small controlled study involving at least 10 people and the drugs properly compounded into topical formulas. We can’t do much with the feedback of one random person from the net who decided to try the drugs topically and does not have a scientific way of observing their hair growth other than holding a mirror in front of another mirror. Would be great if some derm agency would sponsor small studies to see if some of these fringe molecules actually work.



      • D1 on April 29, 2020 at 1:20 pm

        @FollicleThought what are these drugs and how would you know that they would work (safely)?

        A 10 people trial wouldnt be that costly?



        • Follicle Thought on April 29, 2020 at 3:37 pm

          For example D1, the molecules that John mentioned such as topical α-ketoglutarate (α-KG) and topical Rapamycin. There are others, of course, such as fevipiprant. I’m not too high on metformin for hair growth.



          • John on April 29, 2020 at 5:02 pm

            Admin, its not necessary to use drugs topically against Hair loss. If you check the Antiaging Roadmap I copied in there are oral Senolytics already in Phase 2 with drugs you can buy already … Fisetin, Dasatinib, Quercitin … and then the NAD Boosters and of Course the Metabolism drugs. This is the Topic HOPE Med. and Pelage are focusing on. … BTW any News on them? 🙂



            • Follicle Thought on April 29, 2020 at 5:37 pm

              It’s not necessary to use drugs topically for hair loss but it’s usually the best route. I’m not sure about Hope Med but am fairly certain that Pelage will be topical. No news at the moment, but both should have something this year.



  27. Ralf on April 29, 2020 at 10:41 am

    Tsuji Update please



    • Follicle Thought on April 29, 2020 at 10:59 am

      Tsuji updates are about as common as NBA games being played right now. All jokes aside, if Tsuji had a follicle related update to give I’d post it in an article and/or the Updates page. Apparently his lab has created some artificial human skin model which is used to test cosmetic skincare products(?) I believe.



  28. Sam on April 29, 2020 at 9:01 pm

    Hey admin,
    Any updates concerning RT1640 or anything new research that concerns premature grey hair?



  29. peter on April 29, 2020 at 10:05 pm

    Gee only another 5+ years away this time.
    I have no faith in this company.

    I’ll stick it in my pipe dream folder with all the rest.



  30. Rap on April 30, 2020 at 3:48 am

    Did a ton of research into some viable treatments tonight. I’m already dermapenning + LLT + Peppermint Oil to stimulate blood flow and I’m starting to see baby hair coming in. I have full hairline but badly diffuse.

    Considering using bio identical HGH topical from dr on scalp to get thickness and density back.

    Once that is taken care of will probably apply Rapamycin to hair 1 time per week

    Will continue to dermapen 1 time per week 3 days after Rapamycin + daily massage and oils + LLT on Dermapen days.

    Will do further research into aKG as well. May add into the mix.

    I never went deep into aKG or Rapa DD until today. Lone behold I thought Rapa could be cancerous etc and it turns out to potentially be the opposite. Still a risk but f it. It’s either that or chemical castration. Saw Palmetto whooped my ass… enough said.



    • Stephan on April 30, 2020 at 6:27 am

      Such a nightmare i can really understand you. Started bolding with 20 and now 1/3 of my life was a real nightmare if it makes you feel better. Stay strong! Hope we get to live a bit in this f life one day again.



  31. The on April 30, 2020 at 5:57 am

    on your chart pipeline Rivertown has only finished phase 1 of clinical trials, and they announced clincal trials 4 years ago. How can someone be that incompetent and still be in the business?



  32. Mjones on April 30, 2020 at 7:05 pm

    Rivertown, histogen blah. Plain and simple. If it worked and backed by a real legit funded business it would fly through trials like follicum, follica, Samumed and even CB. If histogen ever gets released I’ll buy the admin his first yearly injections lol. Tsuji is 10 years out at best if they are successful. 10 years for everyday common folks like us to get it. Follica, follicum, sm, cb will all be delayed 2 years due to covid 19. Straight up no bs reality right here. Hop on big 3, get an fue and just face the facts.



    • Soul on May 1, 2020 at 12:13 pm

      Mjones, SM, FOLLICA….2 years late? sources? and tsuji 20 years late? sources? thank you



  33. KD on April 30, 2020 at 7:50 pm

    fly through trials like follica and CB? is that satire?



  34. Mjones on April 30, 2020 at 7:54 pm

    Fly as in actually moving forward not stuck in phase 1 for 4 years like riverton or replicel. Follica is moving forward as planned and typical timeline for a clinical trial of 8 to 12 years .



  35. Follicle Thought on April 30, 2020 at 10:29 pm

    I will take you up on those free Histogen injections so I hope you’re not just throwing that offer around jokingly. lol

    But I don’t think funding always relates to a superior product, Samumed seemed to get very lucky with their funding and their hair molecule has only showed 10% increase in a phase 2. I’d guess that both RT and HSC beat that in 6 months.



  36. DueDiligence on May 1, 2020 at 3:38 pm

    Without a doubt any therapies being developed will take time and there will be a high attrition rate. It is important to understand that breakthroughs are built upon the back of both theory AND technology AND economic viability. For example, to clone an organoid like a hair follicle takes an immense amount of theoretical development in the understanding of the biology of the organoid itself as well as the tools to actually execute on that understanding all the while staying afloat with capital backing. Can we clone organs yet? No, so the expectation that we can clone hair tomorrow is unrealistic.

    In the meantime, I’m curious to hear anyone’s experience with stem cell (and other pluripotent cell) injections. Anyone on here have exosome or mesenchymal stem cell injections? There are no clinical trials on these therapies yet so all evidence of their efficacy is anecdotal at best. Perhaps a strong alternative/complement to the big 3…



    • Yoda on May 1, 2020 at 5:22 pm

      I quit smoking pot years ago, if I still did I’d read Due Diligence’s post and it would blow my mind. It’s like the Doors song of hair loss posts! 🙂



      • DueDiligence on May 1, 2020 at 6:35 pm

        lol! Are you making fun of my writing style… I’m happy to have anything I write compared to the Doors!



      • DueDiligence on May 1, 2020 at 6:41 pm

        lol! I will choose to take any comparison to the Doors as a compliment, intended or not.



        • Follicle Thought on May 1, 2020 at 7:41 pm

          I agree, DueDiligence, a comparison to the Doors is a compliment.



          • Yoda on May 3, 2020 at 5:42 pm

            Due, my prior reply must’ve gone into spam. Definitely a compliment deep and poetic! 🙂



          • Yoda on May 3, 2020 at 5:59 pm

            Also, in regards to exosome or mesenchymal stem cell injection, I am highly suspect of this being an effective treatment for androgenic alopecia. I have had 4 sessions (within a year) of PRP/CRP from a reputable doc in the field with little to nothing to show for it, except a lighter wallet. This doc has moved onto exosome/mesenchymal stem cell injections and the only results he could show me was for patients that had other forms of alopecia, besides androgenic. To me, PRP, adipose stem cells, exosome or mesenchymal may have some benefits but not worth what you pay, specifically as they relate to androgenic alopecia. Docs seem to market/spin the slightest results into more than it is, minuscule benefits into major ones. My feeling, and it’s just a feeling, is that transplant docs want to seem to be on the cutting edge and offer the next generation of treatments. It’s a win/win for them in that they get revenue from the treatment itself and if/when it produces sub-optimal results compared to one’s expectations they have a captive patient to hawk a transplant procedure to.



      • DueDiligence on May 3, 2020 at 9:14 pm

        Thanks for your response on this Yoda. Very strong points. The science supporting PRP/A-cell/Exosomes is, of course, most applicable to regenerative medicine as it was initially applied. But some of the anecdotal support for exosomes seems encouraging. I do think these therapies work on a very individual basis, from my research (which has largely been channel checks on doctors) the probability of *successful* outcomes may be elevated for men in the earlier stages of their hair loss journey using as a retention tool (which is my description). Anyway, my occupation(al hazard) is research so I enjoy doing the work on this stuff. I’ve interviewed around 15 doctors in the LA area who offer some form of PRP/A-cell/Exosome therapy. If and when I decide to move forward, I’ll report back on whether or not I found the procedure to be efficacious or not.



  37. Alonso on May 1, 2020 at 5:28 pm

    So, Samumed will released its product around 2022/2023? And I guess that will be the newest hairloss product to be released, am I right? Cause the other are way behind it… Sweet lord, we are forking screwed :s



    • Mjones on May 1, 2020 at 7:22 pm

      Samumed will hit the market 100%. Its backed and funded by several politicians in Washington as wel . Silent investors. Everythhh is about money and returns.



      • Yoda on May 1, 2020 at 8:29 pm

        My old friend Mjones…and by old I mean old like me, but not as old! 🙂 You still using 82M?



      • Alonso on May 3, 2020 at 5:57 pm

        Wow! Politicians? Really? Like… Old pal Biden? :S



    • Nils on May 4, 2020 at 3:33 pm

      *2021/2022



  38. Mjones on May 2, 2020 at 6:21 pm

    Yoda 🙂 Yup still using big 3 and 82M. Doing all I can and waiting for something new that can give me a boost. An extra 10% regrowth with SM or a 30% regrowth with follica would be much appreciated



    • Dante on May 3, 2020 at 2:46 pm

      you can probably get follica on amazon right now. kirkland minoxidil and dermapen 2, yeah?



    • Yoda on May 3, 2020 at 6:04 pm

      Oral minoxidil and dut my man! And/or a higher strength minox topical than that weak 82M stuff. What doc do you get that from? Hopefully not the one in FL who’s last name begins with a “B”, he over-charges for it and will market anything under the sun to put the moola in his pockets.



  39. ba on May 3, 2020 at 8:32 am


    • Follicle Thought on May 3, 2020 at 9:58 am

      Looks like a topical JAK inhibitor intended for eczema, I’m not sure how useful it would be for hair growth but it’s worth a shot. Perhaps interesting for people with alopecia areata.



  40. Paul on May 3, 2020 at 2:02 pm

    Two questions for you lot:

    1) Has anyone looked into Hairstetics? At first glance, it seems like an ideal “solution” for diffuse thinners, but I’m guessing there is a reason why I haven’t heard of them until now. Thoughts?

    2) At the moment, I can’t use finasteride as my wife and I are trying for a child. Would topical finasteride be okay? Or does it go systemic and present the same potential risks?



    • Follicle Thought on May 3, 2020 at 2:31 pm

      I looked into Hairstetics briefly Paul and I sent them an email through their contact form, I did not receive a response and that is a big concern to me. I tend to agree that there is a reason we have not heard of them until now. Wouldn’t this have made it to a European Hair Restoration Society meeting or a big aesthetic conference?

      The finasteride question is better posed to a doctor but I think the topical may present a higher risk because it has more a chance to rub off on household items (pillows etc) and create cross contact.



  41. Paul on May 3, 2020 at 6:57 pm

    Cheers, admin. The pillow point is a good one!

    Oh well. Back to the drawing board!



  42. Follicle Thought on May 3, 2020 at 7:11 pm

    I just mentioned it to one of the stalwart supporters of FT and I share it here as well, if itching for some new content to read, going back is sometimes a great idea. This Stemore article I think is highly underrated, https://folliclethought.com/stemore-new-cell-therapy-company/ The company is working to create adipose stem cells that behave more like DP cells and a DP cell therapy that maintains inductivity.



  43. Mjones on May 3, 2020 at 7:28 pm

    Yoda I get it from a dr in the Philadelphia area. I’m going to stick with propecia. I have a slight heart palpitations since I was a kid so going on oral minox would be a risk. Who is the dr in Florida? Dont all ht docs market their products for a buck. The dr in philly is trying to sell me laser caps lol.



    • Yoda on May 4, 2020 at 2:17 pm

      MJ, good plan not to go with oral minox if you have heart issues. I’m under a doc’s supervision, I also have slightly elevated BP and the minox has bought it down a few points. You might still check out a higher strength topical, my 25 years experience with 15% (and now oral as well) leads me to believe it, or very little of it, goes systemic. I have some minor sides from oral (slight fluid retention) that I never had with topical. I didn’t find 82M special at all, marketing hype. As far as the doc in FL, in respect to the admin I’ll let him go unnamed, don’t want to start a war. Let’s just say he when I was looking to get on 82M he charged a cosult fee and was double the price of a San Diego based derm I ended up getting the product thru. This FL transplant doc has all kinds of treatments he offers on his site, some with little to no history of success. He even offered Zerona laser for weight loss at one time, a treatment that was offered by Chiropractors, etc. that fell off the map because of lack of effectiveness. He has salon services, trains salons, the list goes on. A marketing and revenue generating machine. I find him to be one step removed from a charlatan, unfortunately he’s not alone.



  44. The on May 4, 2020 at 7:53 am

    I missed that Stemore article, good reminder. They plan to relase “functional cosmetic by 2020”, can you check up on that, because I couldn’t find anything about market release on their site?



    • MRKA on May 4, 2020 at 11:58 am

      The, lets hope that this functional cosmetic has more efficacy than NGF-574H from Celino.
      Nevertheless good to get another maintenance product on the market.
      Just the reference to 2% minox is a bit disappointing



  45. JK on May 5, 2020 at 5:29 am

    Hey Admin, is there any response about dr tsuji resigned



    • Follicle Thought on May 5, 2020 at 9:51 am

      No I didn’t get one, but I stand by my original reaction that this title change sounds routine and mostly insignificant.



  46. Sierra on May 5, 2020 at 12:45 pm

    Hello Admin, thank you for all your work!
    Just curious if you have had any contact/news regarding IM176OUT05? Not sure you’ve ever covered this at all actually. The research team published in Nature 2 years ago and seemed pretty promising, I wonder if they ever pursued it further? Any chance we could get an update from them?
    Cheers!



    • Follicle Thought on May 5, 2020 at 2:20 pm

      Thank you Sierra, let me look into this and get back to you and everyone about it. Cheers



  47. Ronan on May 19, 2020 at 4:09 am

    While we might expect a commercial treatment coming over in this very decade, these are just trials which will take years to process. Hopefully some of us present here don’t turn completely bald by then.



  48. Hartmut on May 19, 2020 at 5:14 am

    Tsuji update



  49. Nils on May 19, 2020 at 6:31 am

    Hi Admin,
    when I compare the results from Histogen als Finasteride, Histogen looks much better
    Do you sure, that the results should be similar ?

    Cant Histogen be “better” ?



    • Follicle Thought on May 19, 2020 at 9:58 am

      Over a time period of continuous injections, it absolutely could be better, I just want to stay level headed when making predictions at this point. I’m sure you understand why.



      • Nils on May 19, 2020 at 2:17 pm

        Will they do several injections in their Phase 2 trial?



        • Follicle Thought on May 19, 2020 at 3:31 pm

          Yes, I believe so Nils. The study is said to include dose-ranging and it makes sense that they are observing dose-ranging in regards to # of injections rather than the amount of complex injected, but we’ll see.



          • Nils on May 19, 2020 at 4:04 pm

            But I dont understand one point.
            Why they have to do 4 trials ?

            Last year they did 1 trial.
            Now the 2. (“1a/2b )

            Normally they would need one trial more ?



            • Follicle Thought on May 19, 2020 at 10:23 pm

              Nils, the recent trial was for female AGA and the HSC660 formula did not perform well.



      • Russell Dee on May 19, 2020 at 6:31 pm

        The problem with periodic injections is that the substance that is injected RAPIDLY migrates out of the target area. I just read an article yesterday about a similar treatment that is a twice-daily topically applied solution. This twice-daily applied topical would be much more likely to keep the the medicine going to the follicles continually. It’s nearly the same stuff as HSC except it’s applied topically twice per day. Here is the study:

        https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.19-0410

        And here is the article where i first read about it yesterday.

        https://scitechdaily.com/new-stem-cell-based-topical-solution-helps-bald-people-regrow-hair/



        • Follicle Thought on May 19, 2020 at 10:27 pm

          I believe HSC is a bit more potent than the topical ADSC-CE, but this topical would make a great adjunct to go with HSC injections or other treatments.



          • Russell Dee on May 19, 2020 at 10:51 pm

            HSC is probably more potent than ADSC-CE but you apply ADSC-CE to the head a lot more often than HSC is injected into the scalp. Still, you make a good point that ADSC-CE would make a great adjunct to other treatments, including HSC. You could inject HSC every few months and apply the ADSC-CE regularly to really nourish your follicles.

            It’s my understanding that this ADSC-CE is very similar to HSC.

            And I think a substance called AAPE is already available as a hair loss treatment via injection. AAPE is also similar to Histogen. Here is a site dedicated to AAPE

            http://www.stemcellsgroup.com/aape-products/

            The AAPE at the above site is an injection for hair loss and a cream for skin-care. The skin care version probably wouldn’t work for hair and the injectable AAPE probably won’t stay in the target area very long. But the point is that it looks like AAPE injections for hair loss are already legally available so perhaps ADSC-CE could be legally marketed as well. Follicle Thought should investigate whether or not ADSC-CE can be legally marketed.



            • Follicle Thought on May 20, 2020 at 9:55 am

              As a topical solution the ADSC-CE solution can be marketed Russell.



            • Follicle Thought on May 20, 2020 at 10:03 am

              HSC is a mix of growth factors that are secreted from newborn baby (foreskin) stem cells which are cultured in embryonic like conditions. The secretions are especially potent because of this. ADSC-CE are the proteins secreted by multiplied fat stem cells which have had their cell membrane removed. They are somewhat similar, but different, as the fat was definitely taken from adults. All in all, I think HSC has a slightly higher ceiling, even with periodic injections compared to X number of topical applications a day.



  50. Jonathan Weaver on May 19, 2020 at 9:25 am

    People in 2020 with Norwood 2-3 will be Norwood 4-5 in 2025, so it’s useless. The treatments in clinical trials are not people balding people but for people who will start to bald in a few years. The timeline is off for already balding people.



    • Yoda on May 19, 2020 at 1:34 pm

      I’ve been loosing hair for close to 40 years John. Hopped on available treatments and have saved a good deal of my hair, although not perfect. If/when HSC comes out it will be of use to me and countless others looking for improvement on what we have.



  51. David De on May 19, 2020 at 11:11 am

    Kang-Yell Choi update please!



    • Follicle Thought on May 19, 2020 at 11:16 am

      I will update his article soon. Perhaps at the end of this week. The research is progressing.



  52. Sammy on May 19, 2020 at 12:59 pm

    This is actually wild news if they can do it. HSC in a trial in June 2020?! Would be very great to hear and then see follow up results by Christmas.



  53. Greg on May 19, 2020 at 5:29 pm

    Admin, so I guess this in a way reflects or confirms that the coronavirus isn’t having that big of an effect on slowing down the hair regrowth industry? Would you say that this is true for other companies as well – tsuji, TissUse, stemson… the usual list? Also, I wonder how they are going to do the trial – with masks or sole protective gear or just like normal? After all, the quicker herd immunity spreads the better off we are.



    • Follicle Thought on May 19, 2020 at 10:24 pm

      I think a lot of companies will be able to continue their research behind closed doors. I can’t confirm for all the companies you mentioned but it makes sense. Histogen can really set the tone if they begin a trial in June.



    • Russell Dee on May 19, 2020 at 10:26 pm

      Interesting observation Greg. I hope you’re right.



  54. Russell Dee on May 19, 2020 at 6:21 pm

    Follicle Thought this study just came out yesterday

    https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.19-0410

    Please investigate



    • Follicle Thought on May 19, 2020 at 10:25 pm

      Thanks Russell, I’ve given some feedback in the Updates section. In short, I think the product is cool and has good potential, the visual results are not immense but anything that works and helps, helps.



      • Russell Dee on May 19, 2020 at 10:30 pm

        Follicle Thought, this S. Korean solution was only used for 16 weeks and twice per day. There’s nothing to stop someone from using it 3 times per day and for a full year. Other products are given a full year to determine the benefit.



  55. Hans on May 20, 2020 at 2:29 am

    TissUse update



  56. Nils on May 20, 2020 at 11:37 am

    But I dont understand why its so hard for J.Hewitt to find a Partner?
    I mean they could be a part of a revolution and earn much money



    • Follicle Thought on May 20, 2020 at 1:10 pm

      If it works as planned, yes.



  57. Nils on May 20, 2020 at 1:51 pm

    I mean they wouldnt assist the trial for free.
    They have not much to lose.



  58. Angry!! on June 2, 2020 at 2:57 pm

    TissUse + Tsuji update



    • Yoda on June 2, 2020 at 5:33 pm

      Nothing+Nada!! Really Angry, do you think if Admin had info he’s be holding it back? These posts are pointless…so is my reply.



      • Follicle Thought on June 2, 2020 at 7:12 pm

        Good point Yoda. Yes, Angry I’m going to have to start deleting the continuous replies asking for TissUse or Tsuji updates. They will come in time.



        • Yoda on June 2, 2020 at 7:33 pm

          Hey Admin, it’s been a half hour…how about now, any on TissUse or Tsuji ? 😉



        • Follicle Thought on June 2, 2020 at 10:21 pm

          Russell, the word Angry in my response is the name a previous commenter in this thread. Individuals who spam the same question over and over will be deleted here and there. I’ll run my site the way I see fit, thanks. You’re always welcome to contribute to the site by the way, https://www.patreon.com/FollicleThought



          • Yoda on June 3, 2020 at 1:20 pm

            Well said Admin…once again you are a very patient man and Yoda will stand down. 🙂



        • Russell Dee on June 3, 2020 at 12:07 am

          “Sterling Reputation?” You have the self-promotion thing down pat, don’t you Sunny Boy?

          I intended to respond to a post by FT but I must have accidentally responded to a post by you or else you wouldn’t have responded to my post, right? I didn’t mean to respond to a post by you.
          That having been said, I wasn’t intending to go to Japan this year and come back with a full head of hair so you’ve got me confused with one of your “Sonny Boys”.



  59. D1 on June 2, 2020 at 3:27 pm

    How can a phase1/2a only take 3 months?



    • Yoda on June 2, 2020 at 5:35 pm

      D1…I wonder if they are able to use some of the data from previous trials? Possibly it’s a tweak to the formula and protocol and this trial is just a formality?



    • Follicle Thought on June 2, 2020 at 7:10 pm

      We don’t know how long they are observing the patients though, final observation and photographs could take place after 4-5 months…



  60. Ben on June 3, 2020 at 12:41 pm

    Hi Admin – just a quick question: do you know if the trial is double-blind and with a control group (placebo)? If so then the number of subjects (18) strikes me very low, especially when the trial is targeting not just safety but also efficacy.

    Might also show that they already know exactly what kind of “mixture” they need to take, given the many years of R&D and also from previous trials. Well, anyhow, targeting efficacy is rather unusual for this stage. The good thing is that we know later this year if it works.



    • Follicle Thought on June 3, 2020 at 12:55 pm

      The study is blinded and placebo-controlled. Regarding efficacy, they have completed 2 other trials previously so I do think they probably have a good idea of what’s needed for efficacy.



  61. C on June 3, 2020 at 2:03 pm

    Upon learning of this news yesterday, I purchased a few shares/stocks of Histogen. Did anyone else do the same or am I just wishful and gullible bellend?



    • Follicle Thought on June 3, 2020 at 6:29 pm

      Glad to hear you did that C, well wishes on it.



    • Russell Dee on June 3, 2020 at 9:13 pm

      I saw the original before and after pics. Some aren’t very good and the rest are dodgy. I hope you don’t lose money but….



  62. TwentyAndBalding on June 3, 2020 at 3:16 pm

    If anyone here is a Research scientist here’s an interesting role Stemson is hiring for.
    https://apply.workable.com/stemson-therapeutics/j/CD293CB8CD/



    • Russell Dee on June 3, 2020 at 9:12 pm

      Stemson is still at the research stage so it’s easily 6 – 7 years from the marketplace.



      • KD on June 3, 2020 at 10:29 pm

        No one knows when the new hair multiplication treatments will come to market. Stemson coming out in 6 yrs may be the first ones to market, or maybe not first we don’t know yet.



        • Russell Dee on June 3, 2020 at 10:50 pm

          OK.



  63. Pier on June 4, 2020 at 5:56 am

    Nice to see the press release of Puretech Health, Follica phase 3 is going to start this year with 280 patients due to the convalidation of pahse 2 data by FDA. So in 2020/2021 we will see at leat 3 company in phase 3: Follica, Cassiopea and Samumed.



  64. Batdman on June 4, 2020 at 7:18 am

    Hey admin, what is different in this trial from the trials from before. Have they tweaked with the formula or dosage?



    • Follicle Thought on June 4, 2020 at 12:33 pm

      This trial will include 3 injections of HSC which should show improved efficacy.



  65. Zoloft on June 4, 2020 at 12:22 pm

    Hello admin, may I ask if you think histogen would eventually release in europe? It seems all these companies apart from a few are based in the US, thus making me worry some of these would not even come to Europe unfortunately.



    • Follicle Thought on June 4, 2020 at 12:35 pm

      I’m not certain on the regulatory plans for each company, however I know without a doubt that Histogen would like to immediately get into Europe following the US. Perhaps they can apply in Europe directly after the FDA approves their NDA in US.



      • Zoloft on June 4, 2020 at 1:44 pm

        Thank you for your response. I suppose, Europe may even be more lenient than the USA. I really hope something makes it to here, we really have no options :/ even for teenagers like me.



  66. Soull on June 4, 2020 at 12:57 pm


    • Follicle Thought on June 4, 2020 at 1:22 pm

      Thanks Soul, yes the news is pouring in.



  67. Scalpo Marx on June 28, 2020 at 11:09 pm

    Thanks for the constant updates, admin. What are your thoughts on Wnt and it’s connection with cancer growth? HSC utilizes Wnt7a.



    • Follicle Thought on June 29, 2020 at 10:20 am

      I think Histogen is quite safe. Wnt is a very important pathway in hair growth and it’s true it is also related to cancer, but as far as I know it takes big overstimulation of Wnt to be danergous.



Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.